Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity

Browse trials for

• Dentin Sensitivity 288

Keywords

• Tooth Bleaching
• Cannabidiol
• Dentin Sensitivity

Dentin Sensitivity

288 studies on the registry are indexed under Dentin Sensitivity; 46 are open to participants now.

This study's planned enrollment of 75 is above the median of 60 across 279 interventional studies indexed under Dentin Sensitivity.

Lead sponsor

Universidade Federal do Para is the lead sponsor of 29 studies on the registry; 4 are open to participants now.

Study arms

• Placebo comparator
  Placebo group

  The placebo gel (PG) (natrosol 4%) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with a microbrush actively, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of follow-up. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany)) will be used at two times: baseline (Ti) and one week after the 3rd bleaching session (Tf).

  Drug: Natrosol 4% Gel

• Active comparator
  Control group

  gel with 5% potassium nitrate and 2% sodium fluoride The gel with 5% potassium nitrate and 2% sodium fluoride (NKFG) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with a microbrush actively, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of follow-up. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany) will be used at two

  Drug: Potassium nitrate and sodium fluoride

• Experimental
  Experimental group

  The experimental 2% cannabidiol gel (GCBD) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with an active microbrush, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of followup. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany) will be used at two times: baseline (Ti) and one week after the 3rd bleaching session (Tf).

  Drug: Cannabidiol (CBD) Gel

Interventions

• DrugPotassium nitrate and sodium fluoride

  Drug pages: Potassium nitrate · Sodium Fluoride

  Gel with 5% potassium nitrate and 2% sodium fluoride gel of 5% potassium nitrate and 2% sodium fluoride for topical application to teeth before bleaching with hydrogen peroxide

  Also known as: GC

• DrugCannabidiol (CBD) Gel

  Cannabidiol gel for teeth ( 2% cannabidiol oil) before bleaching with hydrogen peroxide

  Also known as: GCBD

• DrugNatrosol 4% Gel

  placebo gel (natrosol-based gel 4%) for topical application to teeth before bleaching with hydrogen peroxide.

  Also known as: GP

Primary outcomes

1. Measure Degree of Tooth Sensitivity (pain) by a visual analog scale (VAS) After Tooth Whitening

   Experimental cannabidiol and gel (experimental group) and potassium nitrate gel (control group) can change sensitivity related to tooth whitening with hydrogen peroxide 35%. So it is necessary measure this pain. The volunteers will mark on the scale (VAS) the level (1-10) of sensitivity immediately after the intervention, and for a period of 21 days of treatment.

   Time frame: immediately after the intervention, and for a period of 21 days of treatment

Secondary outcomes

1. Change in Color of Teeth Bleached by spectrophotometer (VITA Easyshade)(quantitative method: (ΔE00)

   Silicone trays will be made, with canine-by-canine impressions. A window will be created on the vestibular surface of each canine of the silicone guide using a metal device with a radius of 6 mm, corresponding to the diameter of the spectrophotometer tip. The tip of the device will be inserted into the silicone guide to obtain the color parameters of the CIEL\*a\*b\* system, where L\* represents the value (light or dark); a\* is a measurement of red (a\* positive) or green (a\* negative); b\* is a measurement of yellow (b\* positive) or blue (b\* negative). The sum of the measured values of the upper canines will be used to obtain the averages of each L\*a\*b\* coordinate for each patient. ΔL\*, Δa\* and Δb\* will be calculated by the difference between the time intervals. Subsequently, the color difference between baseline (Ti) and one week after the 3rd bleaching session (Tf) will be calculated using the CIEDE2000 formulas (ΔE00).

   Time frame: There will be two colors readings: - 1: Ti: Base line (Until star first bleaching session); - 2: Tf: one week after the last bleaching session.

Publications

• Sano IS, de Almeida AS, Xavier GMB, Paes YFO, Silva CM, de Freitas MCC, da Costa RS, Araujo JLN. Synthesis of an experimental gel containing cannabidiol oil and evaluation of effects on bleached bovine enamel. Odontology. 2025 Apr 19. doi: 10.1007/s10266-025-01105-5. Online ahead of print. PubMed 40253312 ↗

Individual participant data

Plan to share: No — Brazilian legislation (LGPD), 13.709/2018