An interventional study of Grape Seed Extract and Low-level laser therapy in Dentin Hypersensitivity, sponsored by Manipal University College Malaysia. Recruiting at 1 site in Malaysia. Open to participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-03.
Sponsored by Manipal University College Malaysia · Not applicable, Interventional, and Treatment
Dentin hypersensitivity (DH) is a common clinical problem frequently seen in dental patients. According to Splieth et al., the prevalence of dentin hypersensitivity is 3-98% in adult population.DH is described as a short, sharp pain or discomfort that responses to certain stimuli, typically thermal, tactile, osmotic or chemical, due to exposed dentinal surface which can be explained by the hydrodynamic theory.
The laser is a narrow, focused beam of light emitted to vaporise, fuse, melt, or seal dentinal tubules using laser heat to induce hydroxyapatite crystals for recrystallisation of the mineral component of dentine. The obliteration of dentinal tubules is caused by heat generated by laser beam which inhibits the transmission of the stimulus in the dentinal tubules.
Grape seed extract contains proanthocyanidins (PA) which is able to bind to proline-rich proteins, like collagen, and contributes in enzyme proline hydroxylase activity that is essential for the biosynthesis of collagen in the dentin. The cross-linking action of collagen fibrils in dentin also able to prevent mineral loss.
288 studies on the registry are indexed under Dentin Sensitivity; 46 are open to participants now.
This study's planned enrollment of 30 is below the median of 60 across 279 interventional studies indexed under Dentin Sensitivity.
Browse Dentin Sensitivity studies →Manipal University College Malaysia is the lead sponsor of 5 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
grape seed extract with 95% proanthocyanins will be applied topically to the hypersensitive dentin area for 10 minutes, followed by rinsing with water.
Drug: Grape Seed Extract
The low-level laser diode treatment of 810 nm will be performed using a commercially available diode laser device. The device will be set at a wavelength of 810 nm, with a power output of 0.5 watts tip of diameter 300 μ in non-contact mode starting at a distance of 5-6 mm away from the hypersensitive tooth area and slowly approaching within a distance of 2-3mm in a scanning motion covering the entire hypersensitive tooth area for a period of 30 seconds to 1 minute.
Device: Low-level laser therapy
Grape seed extract will be applied topically to the hypersensitive dentin area for 10 minutes, followed by low-level laser diode treatment.
Drug: Grape Seed Extract · Device: Low-level laser therapy
Grape seed extract will be applied in the form of a gel on the tooth surface
Also known as: GSE
The device will be set at a wavelength of 810 nm, with a power output of 0.5 watts tip of diameter 300 μ in non-contact mode
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)(0 to 10) before and after treatment.
Time frame: 1st day
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)(0 to 10) after treatment.
Time frame: 3rd day
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)
The patients' dentin hypersensitivity levels will be measured using a visual analogue scale (VAS)(0 to 10) after treatment.
Time frame: 7th day
Plan to share: No
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Studies of the drug tested here: Grape Seed Extract
Manipal University College Malaysia