A Phase 4 interventional study of 8.0% Arginine Dentifrice and Electric Sonic Toothbrush in Dentin Sensitivity and Dentin Hypersensitivity, sponsored by Colgate Palmolive. Completed at 1 site in Brazil. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Colgate Palmolive · Phase 4, Interventional, and Treatment
This clinical study evaluates the efficacy of an oral hygiene regimen consisting of an electric sonic toothbrush used in combination with an 8.0% arginine and calcium carbonate toothpaste in reducing dentinal hypersensitivity compared to a manual soft-bristled toothbrush with the same desensitizing toothpaste. Adult participants with tactile/air-blast hypersensitive teeth brush twice daily for 7 days. Sensitivity reductions are evaluated at baseline, immediately post-brushing, at 3 days, and at 7 days.
Dentinal hypersensitivity is a common oral condition characterized by short, sharp pain arising from exposed dentin in response to external stimuli. This single-center, Phase III, randomized, examiner-blind, 2-arm parallel-group clinical trial investigates the efficacy of combining an electric sonic toothbrush with an 8.0% arginine and calcium carbonate toothpaste to alleviate dentinal hypersensitivity.
Eighty adult participants meeting inclusion and exclusion criteria are randomized (1:1 ratio) into two study groups:
Sequence of Study Procedures:
289 studies on the registry are indexed under Dentin Sensitivity; 45 are open to participants now.
This study's enrollment of 80 is above the median of 60 across 280 interventional studies indexed under Dentin Sensitivity.
Browse Dentin Sensitivity studies →Colgate Palmolive is the lead sponsor of 118 studies on the registry; 13 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 2 (6%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants brush twice daily (morning and evening) for 2 minutes using an electric sonic toothbrush and an 8.0% arginine fluoride toothpaste for 7 days.
Drug: 8.0% Arginine Dentifrice · Device: Electric Sonic Toothbrush
Participants brush twice daily (morning and evening) for 2 minutes using an adult soft-bristled manual toothbrush and an 8.0% arginine fluoride toothpaste for 7 days.
Drug: 8.0% Arginine Dentifrice · Device: Adult Soft Bristle Manual Toothbrush
Commercial fluoride toothpaste containing 8.0% arginine and calcium carbonate.
Commercially available electric sonic toothbrush.
Commercially available adult soft bristle manual toothbrush (ADA reference).
Change in Dentinal Hypersensitivity Score (Schiff Cold Air Sensitivity Scale)
Assessment of tooth sensitivity to air blast stimuli applied for 1 second to the exposed cervical surface of qualifying teeth, scored using the Schiff Cold Air Sensitivity Scale (range 0-3, where 0 = no response and 3 = painful response/requests discontinuation)
Time frame: Baseline, immediately post-brushing, Day 3, and Day 7.
Plan to share: No — Individual participant data will not be shared to maintain confidentiality as outlined in the subject consent and privacy terms.
No publications or documents are linked to this record.
Ran from Dec 2021 to primary completion in Feb 2022, 2 months.
Of 14 phase 4 interventional studies under Dentin Sensitivity, half reached primary completion within 2 months of starting (the median); a quarter within 2 and three quarters within 15. This study's 2 months is close to that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.