A Phase 1 interventional study of Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste and Eggshell derived Nano-hydroxyapatite (n-HAp) without a Fluoride containing toothpaste in Dentin Hypersensitivity, Fluoride and Nano-hydroxy Apatite, sponsored by Cairo University. Not yet recruiting. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-10.
Sponsored by Cairo University · Phase 1, Interventional, and Treatment
compare the effectiveness of Eggshell derived nano-Hydroxyapatite with and without fluoride and conventional fluoride containing tooth paste versus conventional desensitizing fluoride containing tooth paste on dentinal tubule occlusion and dentin mineral deposition.
Recently advanced nanotechnology has taken a wide leap in improving the various measures in the treatment of hypersensitivity by its nanoparticles. Nanoparticles can easily penetrate into dentin tubules, which could act as mineralizing agents that block fluid movement within the dentin tubules when combined with various agents.
Hydroxyapatite (HAp) is the major inorganic component of natural teeth and bone. Nano-sized particles of hydroxyapatite are similar to the apatite crystals of tooth enamel in morphology and crystal structure and has been studied as a biomimetic material for the reconstruction of tooth enamel suffering from mineral loss because of its unique potential for remineralization. Nano-hydroxyapatite (n-HAp) was considered a promising active ingredient used for the treatment of DH due to high biocompatibility and bioactivity. In toothpastes, HAp was included in the form of nanocrystals because they dissolve easier in this form. Crystals of n-HAp included in dental products have a dimension of 50-1000 nm, which enables them to act like fillers. These products can penetrate and block the exposed dentinal tubules which are responsible for DH
288 studies on the registry are indexed under Dentin Sensitivity; 46 are open to participants now.
This study's planned enrollment of 39 is below the median of 60 across 279 interventional studies indexed under Dentin Sensitivity.
Browse Dentin Sensitivity studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.
Drug: Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste
patients would be instructed totreat their teeth for 5 min twice a day with the provided toothpaste.
Drug: Eggshell derived Nano-hydroxyapatite (n-HAp) without a Fluoride containing toothpaste
patients would be instructed totreat their teeth for 5 min twice a day with the provided toothpaste.
Drug: Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste
patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.
Also known as: (n-HAp) toothpaste
patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.
Also known as: nano-hydroxyapatite with flouride
Pain intensity due to Dentin Hypersensitivity by Visual Analogue Scale (VAS)
VAS is used to "quantify" the pain severity in millimeter (mm) in response to such query as "Draw a line on the scale that shows how much pain you have at this time " with "no pain" on the far left end of scale at 0 mm and "pain as bad as it can be" on the far right at 100 mm.
Time frame: T (Time): T0= Baseline (before treatment). T1= 7 days. T2= 3 months. T3= 6 months
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This study is not yet recruiting, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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