Anterior Cruciate Ligament Injuries clinical trials
The registry lists 625 studies for Anterior Cruciate Ligament Injuries across more than 10 countries. 192 are recruiting or about to start. 583 of them are mainly about Anterior Cruciate Ligament Injuries (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 712 studies for Anterior Cruciate Ligament Injuries. How that becomes 625 here
This page counts the studies the registry files under Anterior Cruciate Ligament Injuries, and those it files under no condition that list Anterior Cruciate Ligament Injuriesthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 712Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −88Match it another way24 name it in the title, 2 in a keyword, and 62 by a synonym or other text the search reads.
- 624Counted here and found by its search4 of them list Anterior Cruciate Ligament Injuries in their own words; the registry filed them under no condition.
- +1
Counted here, but its search does not find them
- 625The count on this page
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Status
Who runs them
Peking University Third Hospital (33) · University of Michigan (11) · Chinese University of Hong Kong (10) · GCS Ramsay Santé pour l'Enseignement et la Recherche (9) · University of North Carolina, Chapel Hill (8) · Assiut University (7) · Hospital for Special Surgery, New York (7) · University Hospital, Caen (7)
What is being tested here
Drugs under test in Anterior Cruciate Ligament Injuries studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Local anesthetics 4 open · Corticosteroids 6 · NSAIDs 5 · COX-2 inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026PRP in ACLR to Prevent PTOA · Phase 3 · Hospital for Special Surgery, New York
- Nov 2026Obtain Safety and Effectiveness of CT-ACL001, a Regenerative Ligament Using Biological Tissue, in ACLR · CoreTissue BioEngineering Inc.
- Nov 2026Comparison of Methods in Post Operative Knee Arthroscopy Rehabilitation · University of Colorado, Denver
- Nov 2026Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL · Riphah International University
- Nov 2026Effect of Tourniquet Use on the Pivot Shift Test · Umraniye Education and Research Hospital
- Nov 2026Intraoperative Energy Expenditure During ACL Reconstruction Surgery · ASL Lecce
- Dec 2026Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction · University of Michigan
- Dec 2026Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery · University Hospitals Cleveland Medical Center
- Dec 2026MRI Morphology of Femoral Notch in ACL Injury · Assiut University
- Dec 2026Neuromuscular Profiles After Anterior Cruciate Ligament Reconstruction · Hopitaux de Saint-Maurice
Who these studies take
Of the 122 Anterior Cruciate Ligament Injuries studies recruiting now, 27 (22%) set no upper age limit and 92 (75%) stop at 75 or younger. 46 (38%) take children under 18. 2 (2%) are for women only and 3 (2%) for men only; 21 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (9%) | 11 (9%) |
| 18 | 113 (93%) | 114 (93%) |
| 30 | 106 (87%) | 108 (89%) |
| 40 | 94 (77%) | 94 (77%) |
| 50 | 63 (52%) | 63 (52%) |
| 65 | 37 (30%) | 37 (30%) |
| 75 | 29 (24%) | 29 (24%) |
| 85 | 26 (21%) | 26 (21%) |
Across all 625 studies, recruiting or not: 76% stop at 75 or younger and 73% at 65; 36% take children; 4% are for women only and 5% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Anterior Cruciate Ligament Injuries studies take
Of 287 interventional studies with no phase under Anterior Cruciate Ligament Injuries, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 30 mo14–70 · 287 studies | — | 31 mo14–70 · 278 studies |
| Observational | 37 mo13–76 · 82 studies | — | 36 mo12–167 · 73 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting1
- High-purity Magnesium (99.99%) Wire for Augmentation of ACL ReconstructionNov 12, 2026NCT05983692
Results posted1
- Use of Blood Flow Restriction Therapy Following ACL TearNov 3, 2026NCT04374968
Stopped2
- A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric ProductsTerminatedNov 6, 2026NCT06979804
- Andrews Return to Sport ACL ScoreTerminatedNov 2, 2026NCT05578248
Newly registered4
- Stair Biomechanics and Vibration Study After ACLRNov 6, 2026NCT07922785
- Clinical and Biological Outcomes of BioBrace-Augmented ACL ReconstructionOct 30, 2026NCT07906860
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament ReconstructionOct 29, 2026NCT07904949
- Extended Post-Operative Oral Tranexamic Acid Dosing After ACL ReconstructionOct 19, 2026NCT07880743
Studies
Recruiting first, then most recently updated. Showing 50 of 625. Browse all 625 → or search them.
- High-purity Magnesium (99.99%) Wire for Augmentation of ACL ReconstructionRecruitingNCT05983692Not applicable1 country
- Supporting Athletes' Return to Sports After ACL Reconstruction: A Study of a Psychological Readiness ProgramEnrolling by invitationNCT07851298Not applicable1 country
- Stair Biomechanics and Vibration Study After ACLRNot yet recruitingNCT07922785Not applicable1 country
- Graded Exposure and Mindfulness Meditation for Patients Post-ACL ReconstructionRecruitingNCT05949177Not applicable1 country
- Clinical and Biological Outcomes of BioBrace-Augmented ACL ReconstructionNot yet recruitingNCT07906860Not applicable
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament ReconstructionNot yet recruitingNCT07904949Not applicable1 country
- Extended Post-Operative Oral Tranexamic Acid Dosing After ACL ReconstructionNot yet recruitingNCT07880743Phase 31 country
- BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction ProceduresRecruitingNCT069485911 country
- Preventing Injured Knees From osteoArthritis: Severity OutcomesRecruitingNCT06096259Phase 21 country
- Quadriceps Strengthening ACL ReconstructionRecruitingNCT07015541Not applicable1 country
- Evaluation of the Correlation Between Bone Tunnel Projection Placement and Clinical Outcomes in Anterior Cruciate Ligament Reconstruction SurgeryRecruitingNCT078766351 country
- Intraoperative Energy Expenditure During ACL Reconstruction SurgeryRecruitingNCT076832471 country
- Donor Ankle Sensorimotor Recovery After ACL Reconstruction With a Peroneus Longus Tendon AutograftRecruitingNCT077629891 country
- Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. HamstringsRecruitingNCT03896464Not applicable2 countries
- SharkScrew ACL RCTNot yet recruitingNCT07830953Not applicable1 country
- Functional Movement Training Versus Functional Stability Training in Post-ACL SurgeryRecruitingNCT07725016Not applicable1 country
- Neuromuscular Profiles After Anterior Cruciate Ligament ReconstructionRecruitingNCT077928631 country
- Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave TherapyRecruitingNCT06686680Not applicable1 country
- Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACLRecruitingNCT07642752Not applicable1 country
- Effect of Tourniquet Use on the Pivot Shift TestNot yet recruitingNCT07831941Not applicable1 country
- Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL ReconstructionRecruitingNCT07833189Not applicable1 country
- Therapeutic Benefits of a Motor Imaging Protocol Following Anterior Cruciate Ligament Reconstruction SurgeryNot yet recruitingNCT07210489Not applicable1 country
- Reduce Opiate Exposure With ACL SurgeryEnrolling by invitationNCT06561035Phase 31 country
- Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL ReconstructionRecruitingNCT06529692Not applicable1 country
- A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared SpectroscopyNot yet recruitingNCT066213551 country
- Anterior Cruciate Ligament Recovery With Virtual Psychological InterventionRecruitingNCT05965310Not applicable1 country
- Clinical and Functional Outcomes After ACL Reconstruction Versus Primary RepairRecruitingNCT073182721 country
- Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL ReconstructionNot yet recruitingNCT07249645Not applicable
- Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL RuptureNot yet recruitingNCT06945133Not applicable1 country
- Microbiological Molecular Profile of the Knee Joint During Primary Reconstruction or Revision Surgery of the ACLRecruitingNCT07009392Not applicable1 country
- Pain Management of ACL ReconstructionEnrolling by invitationNCT03365908Not applicable1 country
- Psychological Readiness and Return to Sport After ACL ReconstructionNot yet recruitingNCT077338951 country
- Virtual Reality Mindfulness Meditation After ACL ReconstructionRecruitingNCT05527171Not applicable1 country
- Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL ReconstructionRecruitingNCT06975306Not applicable1 country
- A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament ReconstructionEnrolling by invitationNCT07580157Not applicable1 country
- Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament ReconstructionRecruitingNCT076712351 country
- The Psychological Impact of Mindfulness Intervention to Anterior Cruciate Ligament ReconstructionRecruitingNCT06382324Not applicable1 country
- Arthroscopic Anterior Cruciate Ligament Repair Versus Reconstruction for Acute Anterior Cruciate Ligament InjuryRecruitingNCT05584020Not applicable1 country
- Graft Type and Outcomes After ACL Reconstruction in Female AthletesNot yet recruitingNCT077221041 country
- Postoperative Analgesic Efficacy of ACB+iPACK vs FTB+Selective Tibial+Obturator Blocks in ACL ReconstructionNot yet recruitingNCT07702552Not applicable
- ACL Reconstruction: Clinical OutcomeRecruitingNCT034416591 country
- Menstrual Cycle-Synced Neuromuscular TrainingEnrolling by invitationNCT06983184Not applicable1 country
- Quadriceps Tendon vs Peroneus Longus Tendon in ACL ReconstructionRecruitingNCT07671729Not applicable1 country
- Gait Rehabilitation to Treat FastOARecruitingNCT05848622Not applicable1 country
- Assessment of NEURO-K-STARTS Following Primary Anterior Cruciate Ligament (ACL) ReconstructionNot yet recruitingNCT07659613Not applicable1 country
- Assessment of Electromyographic Activity in the Quadriceps and Hamstrings of the Operated Limb Versus the Unaffected Limb in Patients Who Have Undergone ACL Surgery, With and Without Post-operative AMI - an Exploratory StudyNot yet recruitingNCT07659561Not applicable1 country
- Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament ReconstructionEnrolling by invitationNCT04650568Not applicable1 country
- Reducing Disparities in Knee Arthroscopy for AdolescentsNot yet recruitingNCT07580625Not applicable1 country
- Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory StudyNot yet recruitingNCT07655726Not applicable1 country
- Effectiveness of a Digital Prehabilitation Programme Before ACL ReconstructionNot yet recruitingNCT07643480Not applicable