An interventional study of Motor Imagery Therapy (i.e., "mentally practicing movement") and conventional rehabilitation" in ACL Injury, sponsored by Peking University Third Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-22.
Sponsored by Peking University Third Hospital · Not applicable, Interventional, and Treatment
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Among 33 studies in Anterior Cruciate Ligament Injuries by Peking University Third Hospital — 11 open to participants now, 12 under way, none of them phase 3. Anterior Cruciate Ligament Injuries · Peking University Third Hospital.
Among the 33 studies in Anterior Cruciate Ligament Injuries by Peking University Third Hospital, this one is the 11th largest by planned enrollment of the 19 interventional ones that give a count, is one of 4 that started in 2026, is one of 19 with no phase, reaches primary completion later than 9 of the 11 other live ones, and was the 32nd registered.
625 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 192 are open to participants now.
Browse Anterior Cruciate Ligament Injuries studies →11 of the 33 studies in Anterior Cruciate Ligament Injuries by Peking University Third Hospital are open now, in 1 country. Recruiting first, the newest first:
Peking University Third Hospital · Sites in China
Ages 18–45 · Healthy volunteers
Peking University Third Hospital · Sites in China
Ages 18–45
Peking University Third Hospital · Sites in China
Ages 18–40
Peking University Third Hospital · Sites in China
Ages 18–45
Peking University Third Hospital · Sites in China
Ages 18+
By country, each count listing its studies:
Of the 122 Anterior Cruciate Ligament Injuries studies recruiting now, 27 (22%) set no upper age limit and 92 (75%) stop at 75 or younger; 46 take children under 18; 21 take healthy volunteers.
This study: 18 Years to 45 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
33 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 4 started in 2026.
This study's planned enrollment of 80 is above the median of 56 across 458 interventional studies indexed under Anterior Cruciate Ligament Injuries.
Median enrollment 84 across the 19 interventional studies, 115 across the 14 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.
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Peking University Third Hospital is the lead sponsor of 755 studies on the registry; 276 are open to participants now.
5 of the studies in Anterior Cruciate Ligament Injuries by Peking University Third Hospital that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06961292Peking University Third HospitalThe Clinical Efficacy of Anterolateral Complex Augmentation in Patients With ACL Rupture Combined With Excessive Internal Tibial Rotation Subluxation: A Bidirectional Cohort Study | 2026-12-31 |
| NCT07243860Peking University Third HospitalNeuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity | 2027-03 |
| NCT07904949Peking University Third HospitalEffect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction | 2027-06-01 |
| NCT07833189Peking University Third HospitalMotor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction | 2027-08-10 |
| NCT07306221Peking University Third HospitalEffect of Visual-Guided Balance Training on Knee Motor Function and Biomechanical Characteristics After ACL Reconstruction | 2027-08-31 |
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Among the 33 studies in Anterior Cruciate Ligament Injuries by Peking University Third Hospital, from their registry updates:
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Part 1: Neural Correlates of Motor Imagery in ACLR Patients This cross-sectional study aims to systematically compare differences in electroencephalographic (EEG) activity between patients who have returned to sport one year after anterior cruciate ligament reconstruction (ACLR) and healthy controls during functional tasks and associated motor imagery. We will collect EEG activity and behavioral performance data from both groups during task execution and imagination. The primary objective is to verify whether ACLR patients exhibit a specific deficit in motor imagery capability and to characterize the abnormal functional patterns within their central sensorimotor networks. By providing an objective, neurophysiological explanation for why patients struggle to return to sport, this study seeks to establish quantifiable baseline metrics for subsequent interventional research.
Part 2: Effects and Cortical Plasticity Changes Following Motor Imagery-Enhanced Rehabilitation This randomized controlled trial (RCT) combines short-term intervention with long-term follow-up to systematically evaluate the efficacy and mechanisms of motor imagery therapy in ACLR patients. The specific objectives are threefold: First, to verify the immediate effects of the intervention on enhancing neuroplasticity and restoring motor function. Second, to assess the long-term impact on definitive clinical outcomes-specifically return-to-sport rates and time to return-through a 12-month follow-up. Third, to perform a longitudinal analysis determining whether early improvements in neurophysiological indicators can predict subsequent gains in motor performance and successful return-to-sport outcomes.
Part 1 employs a cross-sectional design, comparing patients one year after anterior cruciate ligament reconstruction (ACLR) (experimental group) with healthy adults (control group). This phase aims to acquire electroencephalography (EEG) and lower limb functional data across different states to elucidate the correlation between cortical function and motor behavior.
Part 2 will conduct a 12-week randomized controlled trial (RCT). ACL rupture patients will be allocated to either a motor imagery intervention group or a conventional rehabilitation control group. We will integrate EEG and kinematic analysis to systematically evaluate the therapy's effects on knee function, neuromuscular control, and brain network connectivity. Furthermore, by combining longitudinal EEG and resting-state functional magnetic resonance imaging (rs-fMRI), we will investigate the underlying neuroplastic mechanisms driving functional remodeling within the sensorimotor networks. This research is expected to establish a novel, active intervention strategy based on the "central-driven peripheral" paradigm for ACL postoperative rehabilitation.
Part 1: Participants
Study Design:
Inclusion Criteria for Patient Group:
Exclusion Criteria for Patient Group:
Inclusion Criteria for Healthy Controls:
Study Design:
Inclusion Criteria for Patients:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
aims to acquire electroencephalography (EEG) and lower limb functional data across different states to elucidate the correlation between cortical function and motor behavior.
aims to acquire electroencephalography (EEG) and lower limb functional data across different states to elucidate the correlation between cortical function and motor behavior.
Conventional rehabilitation augmented with motor imagery training.
Behavioral: Motor Imagery Therapy (i.e., "mentally practicing movement")
receiving standard rehabilitation as the control group.
Behavioral: conventional rehabilitation"
Part 2 will conduct a 12-week RCT. The experimental group will receive conventional rehabilitation augmented with motor imagery training. This training will be delivered via a hybrid model (in-person and online) and consist primarily of video-guided imagery sessions.
Also known as: Motor Simulation, Video-Guided Motor Imagery
The control group received conventional rehabilitation only. During in-person sessions, they engaged in passive observation of static photographs, without any form of active mental simulation or motor rehearsal. During remote sessions, they watched the same videos as the experimental group but proceeded directly to physical practice without prior motor imagery.
EEG delta band (0.5-4 Hz) absolute power
Raw EEG data were collected via Smarting Pro during functional assessments.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
EEG theta band (4-8 Hz) absolute power
Raw EEG data were collected via Smarting Pro during functional assessments.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
EEG alpha band (8-13 Hz) absolute power
Raw EEG data were collected via Smarting Pro during functional assessments.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
EEG beta band (13-30 Hz) absolute power
Raw EEG data were collected via Smarting Pro during functional assessments.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
EEG gamma band (30-50 Hz) absolute power
Raw EEG data were collected via Smarting Pro during functional assessments.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Spatiotemporal parameters-Gait Speed
Gait speed recorded during walking using Vicon 3D gait analysis.Unit of Measure: m/s
Time frame: Part 1: cross-sectional assessment at 12 months after ACL reconstruction. Part 2: longitudinal study evaluating patients at preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Spatiotemporal parameters-Step Length
Step length recorded during walking using Vicon 3D gait analysis.Unit of Measure: m
Time frame: Part 1: cross-sectional assessment at 12 months after ACL reconstruction. Part 2: longitudinal study evaluating patients at preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Spatiotemporal parameters-Cadence
Cadence recorded during walking using Vicon 3D gait analysis.Unit of Measure: steps/min
Time frame: Part 1: cross-sectional assessment at 12 months after ACL reconstruction. Part 2: longitudinal study evaluating patients at preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Peak Knee Flexion Angle
Peak knee flexion angle during walking measured using Vicon 3D gait analysis. Unit of Measure: degrees
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Peak Knee Extension Angle
Peak knee extension angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Peak Knee Abduction Angle
Peak knee abduction angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Peak Knee Adduction Angle
Peak knee adduction angle during walking measured using Vicon 3D gait analysis.Unit of Measure: degrees
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Ground Reaction Force - Peak at Initial Contact
Peak vertical ground reaction force at initial contact during walking measured using Vicon 3D gait analysis.Unit of Measure: N/kg
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Vicon 3D Gait Analysis-Peak Knee Flexion Moment
Peak external knee flexion moment during walking measured using Vicon 3D gait analysis.Unit of Measure: Nm/kg
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Electromyography (EMG) testing -Frequency-Domain
Surface electromyography (sEMG) signals were collected from the lower extremity muscles during the Vicon 3D gait analysis to extract frequency-domain features for muscle fatigue assessment.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively
Electromyography (EMG) testing -Time-Domain
Surface electromyography (sEMG) signals were collected from the lower extremity muscles during the Vicon 3D gait analysis to extract time-domain features quantifying muscle activation levels.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively
Functional Magnetic Resonance Imaging (fMRI) testing
A subset of participants underwent task-based fMRI to identify cortical activation patterns during motor imagery.
Time frame: Part 2 includes longitudinal neuroimaging assessments. Resting-state functional magnetic resonance imaging (rs-fMRI) will be performed at preoperative baseline,6 month , and 12 months postoperatively to investigate changes in sensorimotor network conne
Isokinetic muscle strength testing
Isokinetic peak torque of the quadriceps and hamstrings was measured to evaluate muscle strength symmetry between the injured and uninjured limbs.
Time frame: For Part 2, assessments will be conducted at 6 and 12 months postoperatively.
Mental chronometry
Mental chronometry was assessed to compare the imagined duration of movement with the actual execution time.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Kinesthetic and Visual Imagery Questionnaire-20
The KVIQ-20 assesses subjective kinesthetic (body sensations) and visual (mental pictures) imagery abilities related to leg movements. The questionnaire consists of 20 items divided into two dimensions: Kinesthetic and Visual. Each item is rated on a 6-point Likert scale from 0 to 5 based on the clarity and richness of the imagery experienced. The total score ranges from 0 to 100. A higher score indicates greater imagery ability, meaning the patient can more vividly see the movement and feel the muscle/joint activity in their mind.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Tegner Activity Scale
used to assess patients' level of physical activity and participation in sports. This scale ranges from 0 to 10, with higher scores indicating higher activity levels. A score of 0 represents disability due to knee problems (sick leave), while a score of 10 represents participation in competitive sports such as soccer or rugby at a national elite level. The scale captures both work and recreational activities, providing a comprehensive measure of functional activity beyond simple symptom relief.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Visual Analogue Score, VAS
The Visual Analogue Scale (VAS) was used to assess patients' pain intensity at rest or during activity. The scale is typically represented as a 10 cm horizontal line, with "No pain" at one end and "Worst imaginable pain" at the other. Patients mark a point on the line corresponding to their perceived pain level, and the distance from the start is measured as the score.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
International Knee Documentation Committee, IKDC
The IKDC Subjective Knee Form was used to evaluate symptoms (pain, stiffness, swelling, locking/giving way) and functional limitations related to sports and daily activities following ACL reconstruction, as well as current knee function relative to pre-injury status. A normalized total score is calculated from these domains. Scoring Interpretation Minimum Value: Approximately 0 points (representing severe symptoms or complete loss of function) Maximum Value: 100 points (representing no symptoms and fully normal function) Does a higher score mean a better outcome?: Yes. A higher score indicates fewer knee symptoms and better motor function and daily activity performance.
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
Tampa Scale for Kinesiophobia-11 (TSK-11)
Kinesiophobia was assessed using the Tampa Scale for Kinesiophobia-11 (TSK-11). The TSK-11 is an 11-item self-report questionnaire measuring fear of movement and re-injury, rated on a 4-point Likert scale (1 = strongly disagree to 4 = strongly agree). Total scores range from 11 to 44, with higher scores indicating greater kinesiophobia. Scores reflect the severity of fear; therefore, a higher score represents a worse outcome (indicating greater fear).
Time frame: Part 1 involves a cross-sectional assessment at 12 months after ACL reconstruction. Part 2 is a longitudinal study evaluating patients at four time points: preoperative baseline, 12 weeks, 6 months, and 12 months postoperatively.
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Started Jun 2026 (actual). Primary completion is estimated for Aug 2027, 13 months after the start.
Of 278 non-industry interventional studies with no phase under Anterior Cruciate Ligament Injuries, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 70. This study's planned 13 months is below that.
Counting every sponsor, half of 287 studies reached it within 30 months; a quarter within 14 and three quarters within 70.
How these figures are worked out, and which studies are left out of them.
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