An interventional study of Perturbation Training Group and Task-Oriented Functional Activities Group in Anterior Cruciate Ligament Injuries, sponsored by Riphah International University. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-09-24.
Sponsored by Riphah International University · Not applicable, Interventional, and Treatment
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Among 13 studies in Anterior Cruciate Ligament Injuries with a site in Pakistan — 2 open to participants now, 5 under way, none of them phase 3. Anterior Cruciate Ligament Injuries · Pakistan.
Among the 13 studies in Anterior Cruciate Ligament Injuries with a site in Pakistan, this one is the 6th largest by planned enrollment of the 12 interventional ones that give a count, is one of 3 that started in 2026, is one of 12 with no phase, and was the 11th registered.
625 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 192 are open to participants now.
Browse Anterior Cruciate Ligament Injuries studies →2 of the 13 studies in Anterior Cruciate Ligament Injuries with a site in Pakistan are open now. Recruiting first, the newest first:
Riphah International University · Sites in Pakistan
Ages 18–35 · Men only
A study can be open while its sites in Pakistan have not opened yet or have stopped. Only those recruiting at a site in Pakistan →
Of the 122 Anterior Cruciate Ligament Injuries studies recruiting now, 27 (22%) set no upper age limit and 92 (75%) stop at 75 or younger; 46 take children under 18; 21 take healthy volunteers.
This study: 18 Years to 45 Years · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 3 started in 2026.
This study's planned enrollment of 54 is close to the median of 56 across 458 interventional studies indexed under Anterior Cruciate Ligament Injuries.
Median enrollment 52 across the 12 interventional studies, 100 across the 1 observational. Of the 8 that completed or were terminated, 0 (0%) have results posted.
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None of the 13 has an industry lead sponsor. The 6 most frequent:
Riphah International University is the lead sponsor of 2,193 studies on the registry; 650 are open to participants now.
Riphah International University has 6 studies filed under Anterior Cruciate Ligament Injuries — fewer than ten, so there is no comparison to draw.
1 of the studies in Anterior Cruciate Ligament Injuries with a site in Pakistan that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07642752Riphah International UniversityPerturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL | 2026-11-15 |
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Among the 13 studies in Anterior Cruciate Ligament Injuries with a site in Pakistan, from their registry updates:
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Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling knee injuries, particularly in physically active individuals. Despite advancements in surgical techniques, optimal post-operative rehabilitation remains critical for successful functional recovery, minimizing re-injury risk, and restoring pre-injury performance levels
This randomized controlled trial aims to compare the effectiveness of perturbation training and task-oriented functional activities in patients following ACL reconstruction surgery. Perturbation training is a neuromuscular re-education strategy that involves controlled, unexpected movements to enhance joint stability and proprioceptive feedback. In contrast, task-oriented functional training focuses on restoring movement through activities that mimic daily or sports-related functional tasks.
This study will be a Randomized Control Trail and will be conducted in physiogic physiotherapy clinic and Ghurki Trust and Teaching Hospital. Non-Probability Convenient Sampling will be used to collect data. Total of 54 Participants of the age 18-45 years with post 12 weeks to 1 year ACL reconstruction will be included in the study. An informed consent will be taken prior study from all the subjects. Outcomes measure will be included Numerical Pain Rating Scale (NPRS) for pain, Universal Goniometer (UG) for Range of Motion, Y balance test for Knee Stability, International Knee Documentation Committee scores, (IKDC) for Knee function
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Exclusion Criteria:
Participants undergo perturbation-based exercises designed to improve knee stability. It includes balance boards, BOSU balls, and manual perturbation techniques.
Other: Perturbation Training Group · Other: Control Group (Standard Rehabilitation Protocol)
Participants engage in functional movement exercises that mimic daily activities. It includes step training, agility drills, and controlled landing mechanics.
Other: Task-Oriented Functional Activities Group · Other: Control Group (Standard Rehabilitation Protocol)
Participants follow traditional ACL rehabilitation without perturbation or task-oriented interventions. It includes strength training, range-of-motion exercises, and proprioceptive drills.
Other: Control Group (Standard Rehabilitation Protocol)
Two-leg rocker board One-leg rocker board Roller board / stable (weight scale) surface Roller board / BOSU ball TheraBand feedback / perturbation training Simple sport-specific technique on rocker board Moderate demand sport-specific technique on rocker board Advanced sport-specific technique on rocker board This sequence reflects a progressive challenge to knee stability, beginning with bilateral balance tasks, advancing to unilateral control, and culminating in sport-specific perturbation drills.
Functional Recovery Tasks After ACLR Normal walking gait Bilateral squat Unilateral foundation exercises - Single leg squat Bilateral landing Running - Run on treadmill Bilateral plyometric - Bilateral drop jump Unilateral landing / deceleration - Single leg deceleration Unilateral plyometric - Single leg drop jump Change of direction ability / coordination - 90º cut maneuver Sport-specific movements - Movement control under sport-specific change of direction This sequence reflects a progressive load and skill development pathway, starting from basic gait and bilateral tasks, moving toward unilateral control, plyometrics, and finally sport-specific agility.
Heating pad (5-10 minutes) TENS (short bursts, 10-15 minutes, frequency 100 Hz) Stationary cycling Gentle range of motion exercises Passive and active-assisted ROM Isometric quadriceps contractions Straight leg raises Quadriceps setting with a towel under the knee Closed-chain exercises (e.g., wall sits, mini-squats) Hamstring curls Double-leg stance on foam pad This set emphasizes pain relief, mobility restoration, and foundational strength before progressing to advanced neuromuscular or sport-specific tasks.
NPRS for Pain
Numeric Pain Rating Scale (NPRS) it is a unidimensional scale to measure pain intensity, particularly in adults. It is a 10-rating scale and an 11-point numeric scale in the form of a horizontal bar or line
Time frame: 6 weeks
Universal Goniometer for Range of motion
A universal goniometer (UG) will be used to determine the range of motion of the target joint.
Time frame: 6 weeks
The Y-Balance test (YBT)
The Y-Balance test (YBT) is used to assess dynamic balance impairments associated with lower extremity injuries such as ACL injury, patellofemoral pain syndrome, and ankle instability.
Time frame: 6 weeks
International Knee Documentation Committee scores (IKDC)
Patients' knee function is evaluated using the International Knee Documentation Committee's (IKDC) Subjective Knee Form. Through 18 questions, it assesses symptoms, athletic activity, and general knee function; higher scores indicate better knee function.
Time frame: 6 weeks
Plan to share: No
Started Aug 2026 (actual). Primary completion is estimated for Nov 2026, 3 months after the start.
Of 278 non-industry interventional studies with no phase under Anterior Cruciate Ligament Injuries, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 70. This study's planned 3 months is below that.
Counting every sponsor, half of 287 studies reached it within 30 months; a quarter within 14 and three quarters within 70.
How these figures are worked out, and which studies are left out of them.
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