An observational study in Anterior Cruciate Ligament Injuries and Knee Injuries, sponsored by Universidad Católica San Antonio de Murcia. Not yet recruiting at 1 site in Spain. Open to female participants aged 16 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-07-23.
Sponsored by Universidad Católica San Antonio de Murcia · Observational
This prospective multicenter cohort study aims to compare clinical and functional outcomes between hamstring tendon and quadriceps tendon autografts in anterior cruciate ligament (ACL) reconstruction in female athletes. Participants will be followed for two years after surgery to evaluate graft failure rates, return to sport, knee stability, and patient-reported outcomes.
Anterior cruciate ligament injuries are particularly prevalent in female athletes and represent a major challenge in sports medicine. The choice of graft type in ACL reconstruction may influence clinical outcomes, yet evidence specifically in female populations remains limited. This study prospectively enrolls female athletes undergoing ACL reconstruction with either hamstring tendon or quadriceps tendon autograft across multiple centers in Spain. Primary outcome is graft failure rate at 24 months. Secondary outcomes include return to sport rate, IKDC score, KOOS, Lysholm scale, limb symmetry index, and re-injury rate. Data will be collected preoperatively and at 6, 12, and 24 months postoperatively.
625 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 192 are open to participants now.
This study's planned enrollment of 82 is below the median of 98 across 153 observational studies indexed under Anterior Cruciate Ligament Injuries.
Browse Anterior Cruciate Ligament Injuries studies →Universidad Católica San Antonio de Murcia is the lead sponsor of 138 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Female athletes aged 16 to 35 years undergoing primary ACL reconstruction with either hamstring tendon or quadriceps tendon autograft across multiple sports medicine centers in Spain.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Female athletes undergoing ACL reconstruction with hamstring tendon autograft
Procedure: Hamstring tendon autograft ACL reconstruction
Female athletes undergoing ACL reconstruction with quadriceps tendon autograft
Procedure: Quadriceps tendon autograft ACL reconstruction
ACL reconstruction using ipsilateral hamstring tendon autograft (semitendinosus and gracilis tendons) with arthroscopic technique
ACL reconstruction using ipsilateral quadriceps tendon autograft with arthroscopic technique
Graft failure rate
Proportion of patients requiring revision ACL reconstruction or presenting with objetive graft rupture confirmed by MRI or arthroscopy
Time frame: 24 months after surgery
return to sport rate
proportion of athletes who returned to their pre-injury sport level, assessed by athlete and surgeon
Time frame: 12 and 24 months after surgery
IKDC Subjective knee Evaluation Form
Patient-reported outcomes measure assessing knee symptoms, function and sports activity.
Time frame: 6, 12 and 24 months after surgery
KOOS (Knee Injury and Osteoarthritis outcome Score)
Patient-reported outcome measure assessing pain, symptoms, function in daily living, function in sport and recreation, and knee-related quality of life
Time frame: 6, 12 and 24 months after surgery
Lysholm Knee Scoring Scale
Clinician-reported outcome measure assessing knee function including pain, instability, locking, swelling, stair climbing, squatting and limp
Time frame: 6, 12 and 24 months after surgery
Limb Symetry Index (LSI)
Assessed vy isokinetic dynamometry and single-leg hop tests to evaluate quadriceps and hamstring strength symmetry between limbs
Time frame: 6, 12 and 24 months after surgery
Re-injury rate
Proportion of patients sustaining a new ipsilateral or contralateral ACL injury during the follow-up period.
Time frame: 24 months after surgery
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Anterior Cruciate Ligament Injuries →
Universidad Católica San Antonio de Murcia →