Knee Injuries clinical trials
The registry lists 267 studies for Knee Injuries across more than 10 countries. 59 are recruiting or about to start. 161 of them are mainly about Knee Injuries (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 5 narrower conditions too, such as Anterior Cruciate Ligament Injuries: 959 studies, 263 open.
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Status
Who runs them
Stanford University (5) · Mayo Clinic (4) · Assiut University (4) · The University of Tennessee, Knoxville (3) · Istituto Ortopedico Rizzoli (3) · eMKa MED Medical Center (3) · Keller Army Community Hospital (3) · Northwestern University (3)
What is being tested here
Drugs under test in Knee Injuries studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children · Phase 3 · University of Calgary
- Nov 2026Maximizing Patient Goal Attainment · Dartmouth-Hitchcock Medical Center
- Dec 2026DePuy Synthes Variable Angle LCP Patella Plating System Study · Hartford Hospital
- Dec 2026Fixation of Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction. Endobutton vs Metal Interference Screws · St. Olavs Hospital
- Dec 2026Stopping OsteoARthritis After an ACL Tear · University of British Columbia
- Feb 2027Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery · Stanford University
- Feb 2027A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee · Smith & Nephew, Inc.
- Apr 2027Establishing the Clinical Significance Values of the Lysholm Knee Score · Kırklareli University
- Apr 2027Validity and Reliability of the Turkish Version of the Tegner Activity Score · Kırklareli University
- Jun 2027STaR Trial: Multiple Ligament Knee Injuries · University of Pittsburgh
Who these studies take
Of the 42 Knee Injuries studies recruiting now, 12 (29%) set no upper age limit and 27 (64%) stop at 75 or younger. 12 (29%) take children under 18. 0 (0%) are for women only and 2 (5%) for men only; 9 (21%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (10%) | 4 (10%) |
| 18 | 35 (83%) | 37 (88%) |
| 30 | 35 (83%) | 37 (88%) |
| 40 | 32 (76%) | 33 (79%) |
| 50 | 28 (67%) | 28 (67%) |
| 65 | 17 (40%) | 17 (40%) |
| 75 | 15 (36%) | 15 (36%) |
| 85 | 13 (31%) | 13 (31%) |
Across all 267 studies, recruiting or not: 67% stop at 75 or younger and 60% at 65; 23% take children; 4% are for women only and 4% for men only; 28% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Knee Injuries studies take
Of 99 interventional studies with no phase under Knee Injuries, half reached primary completion within 20 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 20 mo8–51 · 99 studies | — | 21 mo8–51 · 94 studies |
| Observational | 22 mo11–56 · 30 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Results posted1
- Use of Blood Flow Restriction Therapy Following ACL TearNov 3, 2026NCT04374968
Studies
Recruiting first, then most recently updated. Showing 50 of 267. Browse all 267 → or search them.
- Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.RecruitingNCT078334881 country
- Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal LossRecruitingNCT06376422Not applicable1 country
- Knee Cartilage Repair RegistryRecruitingNCT077862071 country
- Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament ReconstructionRecruitingNCT05073276Not applicable1 country
- Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament ReconstructionRecruitingNCT05073263Not applicable1 country
- Kinesiotaping in Isolated Meniscus InjuriesRecruitingNCT07574307Not applicable1 country
- Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated "Stener-like" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular FracturesRecruitingNCT071742191 country
- Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at RiskRecruitingNCT07406516Not applicable1 country
- Evaluation of Long-term Isokinetic Training of Knee JointRecruitingNCT06674473Not applicable1 country
- Evaluation of Sport Injuries of Knee by MRIRecruitingNCT077950081 country
- Blood Flow Restriction Training After Patellar INStabilityRecruitingNCT04554212Not applicable1 country
- Graft Type and Outcomes After ACL Reconstruction in Female AthletesNot yet recruitingNCT077221041 country
- Fixation of Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction. Endobutton vs Metal Interference ScrewsRecruitingNCT02918734Not applicable1 country
- A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the KneeEnrolling by invitationNCT069167286 countries
- Gait Rehabilitation to Treat FastOARecruitingNCT05848622Not applicable1 country
- Reducing Disparities in Knee Arthroscopy for AdolescentsNot yet recruitingNCT07580625Not applicable1 country
- Evaluation of Different Patterns PHMM Root TearsNot yet recruitingNCT07602985
- Quadriceps Motor Unit Adaptation to Simulated Knee InjuryRecruitingNCT06999057Early Phase 11 country
- Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in ChildrenRecruitingNCT07145645Phase 31 country
- Descriptive Study of Multiligamentary Reconstruction of the KneeRecruitingNCT03932838Not applicable1 country
- Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor HealthRecruitingNCT053440011 country
- Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic SurgeryRecruitingNCT03858231Phase 41 country
- Validity and Reliability of the Turkish Version of the Tegner Activity ScoreRecruitingNCT065712401 country
- Establishing the Clinical Significance Values of the Lysholm Knee ScoreRecruitingNCT065712271 country
- Comparison Between the Use of the Tensioner and Standard Surgical Technique for Ligament Balancing of Total Knee ProsthesesRecruitingNCT06770153Not applicable1 country
- Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic SurgeryRecruitingNCT04109638Not applicable1 country
- The Effects of Neuromuscular Training on Knee Biomechanics During Jump-Landing Among College Basketball Players Post ACL Reconstruction and RehabilitationNot yet recruitingNCT07314931Not applicable1 country
- The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled TrialRecruitingNCT05754632Not applicable1 country
- Effect of Blood Flow Restriction Rraining on Rehabilitation After Anterior Cruciate Ligament ReconstructionNot yet recruitingNCT07311031Not applicable1 country
- Effects of MWM Vs Sustained Mobilization on Knee OsteoarthritisNot yet recruitingNCT07315464Not applicable1 country
- Clinical and Instrumental Assessment of Meniscal ROOT Tears Treated Through Suture to the Posterior Cruciate LigamentRecruitingNCT065072411 country
- Fibrine Clot-augmented Repair of Longitudinal Meniscus TearsRecruitingNCT06541756Not applicable1 country
- Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)RecruitingNCT072015971 country
- Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee OsteoarthritisNot yet recruitingNCT07157891Early Phase 1
- Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled TrialNot yet recruitingNCT07145606Not applicable2 countries
- SportsPro: Post-Market Clinical Follow Up StudyRecruitingNCT063209251 country
- Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)Not yet recruitingNCT069802851 country
- Comparison of Patella Plating Versus Tension Band Wiring for the Treatment of Unstable Patellar FracturesRecruitingNCT06981039Not applicable1 country
- Arabic Version of Marx Activity Rating and Knee Stability in Sports/Cutting-Pivoting Ability ScalesRecruitingNCT054707901 country
- OrthoPureXT Multiligament PMCF StudyRecruitingNCT05655156Not applicable1 country
- Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility StudyEnrolling by invitationNCT068928991 country
- Effectiveness of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Open Knee SurgeriesEnrolling by invitationNCT06562634Not applicable1 country
- Evaluation of Vastus Medialis Muscle Inhibition in Indoor Soccer Players with and Without ACL InjuryNot yet recruitingNCT06599164
- Knee Osteoarthritis in the Region of NorrbottenRecruitingNCT064515101 country
- The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.RecruitingNCT06442319Not applicable1 country
- Stopping OsteoARthritis After an ACL TearRecruitingNCT06195423Not applicable1 country
- IVR in Motor RehabilitationRecruitingNCT05364970Early Phase 11 country
- Clinical and MRI Evaluation of ACL Reconstruction Results in Adolescents With Follow-up at Least 3 Years.RecruitingNCT05180123Not applicable1 country
- Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage DefectsRecruitingNCT02090140Not applicable1 country
- Biomechanical Analysis of Dynamic Tasks and Muscular Strength Following Anterior Cruciate Ligament ReconstructionRecruitingNCT027715481 country