An observational study in Anterior Cruciate Ligament Injury, sponsored by Hopitaux de Saint-Maurice. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Hopitaux de Saint-Maurice · Observational
The NEURO-ACL-ISOEMG study is an observational, cross-sectional, exploratory study conducted in patients between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction.
The primary objective is to describe the joint distribution of isokinetic muscle strength and surface electromyographic (sEMG) activation parameters of the quadriceps and hamstrings in order to explore different neuromuscular profiles under clinical conditions.
The study combines data from the routine functional assessment, including isokinetic strength measurements and a single-leg hop test, with surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.
Persistent muscle strength deficits are frequently observed after anterior cruciate ligament (ACL) reconstruction and may be related to both peripheral muscular factors and alterations in neuromuscular activation. However, few studies have simultaneously assessed isokinetic strength and electromyographic activation of both agonist and antagonist muscles under analytical and functional conditions.
NEURO-ACL-ISOEMG is a monocentric, observational, cross-sectional, exploratory study designed to characterize neuromuscular profiles in patients evaluated between 4 and 12 months after ACL reconstruction.
The primary objective is to describe the joint distribution of isokinetic muscle strength and surface electromyographic activation parameters of the quadriceps and hamstrings. Isokinetic assessment includes quadriceps and hamstring peak torque and the Limb Symmetry Index (LSI). Surface electromyography is used to assess activation of the vastus medialis, vastus lateralis, semitendinosus, and biceps femoris during standardized isometric contractions.
Secondary objectives include describing electromyographic patterns during a single-leg functional task, exploring the concordance between electromyographic parameters obtained under analytical and functional conditions, describing the distribution of patients according to different combinations of isokinetic strength and electromyographic activation, and exploring associations between neuromuscular profiles, functional performance, and psychological factors. The study also assesses the completeness and usability of data obtained from the functional assessment in routine clinical practice.
Participants undergo a single study visit during their routine functional assessment after ACL reconstruction. Routine assessment includes isokinetic strength measurements and a single-leg hop test. For the purposes of the study, surface electromyography and three patient-reported questionnaires are added: the Knee Self-Efficacy Scale (K-SES), the Tampa Scale for Kinesiophobia (TSK), and the International Knee Documentation Committee (IKDC) questionnaire.
The study does not modify the participants' therapeutic management and is not intended to establish an individual diagnosis. Its purpose is to provide an exploratory characterization of the heterogeneity of neuromuscular recovery after ACL reconstruction and to generate hypotheses that may contribute to the interpretation of functional assessments and future rehabilitation strategies.
625 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 192 are open to participants now.
This study's planned enrollment of 30 is below the median of 98 across 153 observational studies indexed under Anterior Cruciate Ligament Injuries.
Browse Anterior Cruciate Ligament Injuries studies →Hopitaux de Saint-Maurice is the lead sponsor of 16 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults who underwent anterior cruciate ligament (ACL) reconstruction and are evaluated between 4 and 12 months postoperatively during a routine functional assessment at the study site.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adults evaluated between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction as part of their routine functional assessment. Participants undergo isokinetic strength assessment and a single-leg hop test as part of routine care, complemented for the study by surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.
Other: Neuromuscular and Patient-Reported Assessmen
Surface electromyography of the quadriceps and hamstrings is performed using surface electrodes. Participants also complete the Knee Self-Efficacy Scale (K-SES), Tampa Scale for Kinesiophobia (TSK), and International Knee Documentation Committee (IKDC) questionnaire. These assessments are performed during the same visit as the routine functional assessment.
Distribution of Neuromuscular Profiles
Participants will be classified into neuromuscular profiles based on the combined pattern of isokinetic strength and surface electromyographic activation of the quadriceps and hamstrings. The primary outcome will be the proportion of participants belonging to each identified neuromuscular profile, expressed as a percentage of the study population.
Time frame: During the single study visit, between 4 and 12 months after ACL reconstruction
Surface Electromyographic Activity During the Single Leg Hop for Distance
Surface electromyographic activity of the vastus medialis, vastus lateralis, semitendinosus, and biceps femoris recorded during the Single Leg Hop for Distance.
Time frame: During the single study visit, between 4 and 12 months after ACL reconstruction
Distribution of Participants Across Neuromuscular Profile
Proportion of participants belonging to each neuromuscular profile defined from the observed combinations of isokinetic strength deficit and level of surface electromyographic activation.
Time frame: During the single study visit, between 4 and 12 months after ACL reconstruction
Correlation Between Neuromuscular Parameters and Functional and Patient-Reported Outcomes
Correlations between neuromuscular parameters and functional and patient-reported outcomes will be assessed using correlation coefficients. Functional performance will be assessed using the Single Leg Hop for Distance. Patient-reported outcomes will include scores from the Knee Self-Efficacy Scale (K-SES), Tampa Scale for Kinesiophobia (TSK), and International Knee Documentation Committee (IKDC) questionnaire. Correlation coefficients will range from -1 to +1, with values closer to -1 or +1 indicating stronger correlations and values closer to 0 indicating weaker correlations.
Time frame: During the single study visit, between 4 and 12 months after ACL reconstruction
Completeness of Neuromuscular and Functional Assessment Data
Percentage of participants with complete data available for the planned analyses, including isokinetic strength, surface electromyography, Single Leg Hop for Distance, and patient-reported questionnaire data. Data completeness will be calculated as the number of participants with complete datasets divided by the total number of participants included in the study, multiplied by 100.
Time frame: During the single study visit, between 4 and 12 months after ACL reconstruction
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Dec 2026, 3 months after the start.
Start moved once since we started tracking on Sep 25, 2026: Sep 2026 → Aug 2026, on Sep 29, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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