Heart Failure, Diastolic clinical trials

The registry lists 199 studies for Heart Failure, Diastolic across more than 10 countries. 44 are recruiting or about to start. 136 of them are mainly about Heart Failure, Diastolic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 100
Recruiting: 29
Terminated: 21
Status unknown: 21
Not yet recruiting: 12
Active, not recruiting: 8

Phase

Phase 2: 27
Phase 4: 24
Phase 3: 13
Phase 1: 9
Early Phase 1: 2

Where

United States: 95
Germany: 15
Netherlands: 10
Canada: 10
Italy: 9
Sweden: 7

Who runs them

Mayo Clinic (9) · University of Michigan (5) · University of Texas Southwestern Medical Center (5) · CorAssist Cadiovascular Ltd. (3) · Weill Medical College of Cornell University (3) · Herlev and Gentofte Hospital (3) · Duke University (3) · Hospital de Clinicas de Porto Alegre (2)

What is being tested here

Drugs under test in Heart Failure, Diastolic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Empagliflozin	1	0	3
Butylene glycol	1	0	1
Butylene Glycols	1	0	1
Finerenone	1	0	1
Bimagrumab	1	0	1
Henagliflozin	1	0	1
Tirzepatide	1	0	1
Carvedilol	1	0	1
Selenium	1	1	1
Biomarkers	1	0	1

Drug classes tested here Beta blockers 2 open · SGLT2 inhibitors 2 open · Mineralocorticoid receptor antagonists (MRAs) 1 open · PDE5 inhibitors 5

Coming up

1phase 3 study under way

15studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Nov 2026Multiple-biomarker Approach for Individualized Treatment of Heart Failure With Preserved Ejection Fraction · Erasmus Medical Center
Dec 2026Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status · University of Virginia
Feb 2027A Preliminary Study for INFORMED · Weill Medical College of Cornell University
Feb 2027Dancing as an Alternative to the Traditional Exercising in Older Adults With Cardiac Diseases · University College, London
Mar 2027Heart Failure and Postoperative Outcome in Surgery - a National Registry Study · Umeå University
Mar 2027Cardiovascular and Renal Endpoints With Flozins - an Observational Prospective Study in CKD HFpEF Patients · Grigore T. Popa University of Medicine and Pharmacy
Jun 2027Chronic Exogenous Ketosis in HFpEF · Duke University
Jun 2027Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging · Chinese Academy of Medical Sciences, Fuwai Hospital
Jul 2027RESPONDER-HF Trial · Corvia Medical
Aug 2027Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure · Mayo Clinic

Who these studies take

Of the 29 Heart Failure, Diastolic studies recruiting now, 21 (72%) set no upper age limit and 4 (14%) stop at 75 or younger. 3 (10%) take children under 18. 2 (7%) are for women only and 0 (0%) for men only; 6 (21%) take healthy volunteers.

Recruiting studies that take each age, of 29
Age	Women	Men
10	3 (10%)	3 (10%)
18	19 (66%)	18 (62%)
30	23 (79%)	22 (76%)
40	25 (86%)	24 (83%)
50	27 (93%)	25 (86%)
65	28 (97%)	27 (93%)
75	26 (90%)	25 (86%)
85	25 (86%)	24 (83%)

Across all 199 studies, recruiting or not: 10% stop at 75 or younger and 4% at 65; 5% take children; 3% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Heart Failure, Diastolic studies take

Of 45 interventional studies with no phase under Heart Failure, Diastolic, half reached primary completion within 48 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	48 mo26–62 · 45 studies	—	44 mo26–57 · 39 studies
Observational	71 mo26–130 · 27 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting1

PrEcision Pacing in HFpEF: the PEP-HFpEF TrialOct 20, 2026NCT07864558

Newly registered2

A Study of Bimagrumab in Participants With HFpEFNov 6, 2026NCT07920887
Exercise, Mediterranean Diet and Inflammation in Heart FailureOct 21, 2026NCT07885514

Studies

Recruiting first, then most recently updated. Showing 50 of 199. Browse all 199 → or search them.