Spironolactone: all 176 studies that test it
Page 1 of 2. Open to participants first (26), then studies with results posted, then the rest; newest registration first within each.
- Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia.Not yet recruitingNCT07715318Phase 2
- SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive TherapyNot yet recruitingNCT07687160Phase 4
- Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic StenosisNot yet recruitingNCT07539259Phase 2
- HEART: Pilot Randomized Controlled TrialRecruitingNCT07483177Phase 1/2
- Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face StudyNot yet recruitingNCT07473895Phase 2
- A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First ProgressionNot yet recruitingNCT07431216Phase 1/2
- Spironolactone and XPB-1 Integrity in the TFIIH ComplexEnrolling by invitationNCT07415811Not applicable
- Spironolactone to Improve Pregnancy-Associated Hypertension TrajectoriesRecruitingNCT07041281Phase 2
- The Role of Skin Sodium Accumulation in Chronic Kidney DiseaseRecruitingNCT07020104Not applicable
- Optimal Medical Treatment of Difficult-to-treat HypertensionRecruitingNCT06275763Phase 4
- SPironolactONe for the Maintenance of Sinus Rhythm in Patients With Atrial FibrillationNot yet recruitingNCT06204640Phase 3
- Determination of Drug Levels for Pharmacotherapy of Heart FailureNot yet recruitingNCT06035978Phase 4
- A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric PatientsNot yet recruitingNCT06021860Phase 4
- Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity (SPIROTOX)Not yet recruitingNCT06005259Phase 4
- Spironolactone in Alcohol Use Disorder (SAUD)RecruitingNCT05807139Phase 1
- Quadruple Immunotherapy for NeuroblastomaRecruitingNCT05754684Phase 2
- A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)RecruitingNCT05394142Phase 2
- Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic BurdenRecruitingNCT05230901Phase 3
- Evaluation of Spironolactone Efficacy in Patient with Rheumatoid Arthritis (RA)RecruitingNCT05092984Phase 3
- Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?RecruitingNCT04723862Early Phase 1
- Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?RecruitingNCT04075149Early Phase 1
- A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart FailureEnrolling by invitationNCT03984591Phase 4
- Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVDRecruitingNCT03593317Phase 2
- Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection FractionRecruitingNCT02901184Phase 3
- Spironolactone for Pulmonary Arterial HypertensionRecruitingNCT01712620Phase 2
- Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422759Not applicable
- Antiarrhythmic Effects of Spironolactone in Patients With ICDsCompletedNCT04495712Phase 4Results posted
- Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender WomenCompletedNCT04283656Phase 1Results posted
- Metabolic and Neuro-Endocrine Effect of Treating PCOS in AdolescentsCompletedNCT03981861Phase 2/3Results posted
- Drug-drug Interaction (DDI) Study of Spironolactone (Perpetrator) and Digoxin (Substrate Drug)CompletedNCT03909529Phase 1Results posted
- Spironolactone Versus Prednisolone in DMDTerminatedNCT03777319Phase 1Results posted
- Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-OnTerminatedNCT03597035Phase 4Results posted
- Spironolactone Therapy In Young Women With NASHCompletedNCT03576755Phase 1/2Results posted
- Spironolactone After Liver TransplantCompletedNCT02883400Phase 4Results posted
- Mineralocorticoid Receptor Antagonists (MRA) in Heart Failure (HF) and Loop Diuretic ResistanceCompletedNCT02585843Phase 2/3Results posted
- Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney DiseaseCompletedNCT02497300Phase 2Results posted
- Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular DystrophyCompletedNCT02354352Phase 3Results posted
- Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD TrialCompletedNCT02285920Phase 2Results posted
- The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension StudyTerminatedNCT02253394Phase 4Results posted
- Tissue Sodium in Pre-hypertensive PatientsCompletedNCT02236520Phase 2Results posted
- Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart FailureCompletedNCT02235077Phase 2Results posted
- Biomarker Guided Therapies in Stage A/B Heart FailureCompletedNCT02230891Phase 2Results posted
- Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis TrialCompletedNCT02169089Phase 4Results posted
- Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart FailureCompletedNCT01973335Phase 4Results posted
- Etiology of Sleep Apnea-related Hyperaldosteronism - BP TreatmentCompletedNCT01897727Not applicableResults posted
- Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and CetuximabCompletedNCT01867294Phase 2Results posted
- Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)CompletedNCT01853553Phase 3Results posted
- Evaluation of CLP With and Without Spironolactone in Heart Failure Patients With Chronic Kidney DiseaseCompletedNCT01598740Phase 1Results posted
- Mineralocorticoid Receptor and Obesity Induced Cardiovascular ComplicationsCompletedNCT01406015Not applicableResults posted
- Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)CompletedNCT01371747Phase 2Results posted
- Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained MenCompletedNCT01294319Phase 2Results posted
- Aldosterone and the Metabolic SyndromeCompletedNCT01103245Phase 1Results posted
- Spironolactone in Adult Congenital Heart DiseaseCompletedNCT01069510Phase 2Results posted
- The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant HypertensionCompletedNCT01062763Phase 3Results posted
- Clinical and Therapeutic Implications of Fibrosis in Hypertrophic CardiomyopathyCompletedNCT00879060Phase 4Results posted
- Role of Mineralocorticoid Receptor in Diabetic Cardiovascular DiseaseCompletedNCT00865124Not applicableResults posted
- Effect of Aldosterone on Energy Starvation in Heart FailureCompletedNCT00574119Phase 4Results posted
- Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs AloneCompletedNCT00391846Phase 4Results posted
- Spironolactone in Patients With Single Ventricle HeartCompletedNCT00211081Not applicableResults posted
- Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)CompletedNCT00141778Phase 2/3Results posted
- PIE II: Pharmacological Intervention in the Elderly IICompletedNCT00123955Phase 3Results posted
- Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic FunctionCompletedNCT00094302Phase 3Results posted
- Low-Dose Spironolactone in Hemodialysis Patients With Resistant HypertensionCompletedNCT07888504Phase 4
- Unmitigated Aldosterone Signaling During Standard Clinical MRA DosingActive, not recruitingNCT07281014Phase 4
- Bioavailability and Bioequivalence Study of Extended Release Torsemide and SpironolactoneCompletedNCT07046975Phase 3
- Bioavailability and Bioequivalence Study of ER Torsemide and Spironolactone FDC Tablet in Healthy SubjectsCompletedNCT07015671Phase 3
- Bioequivalence Study of Spironolactone Tablets in Healthy SubjectsCompletedNCT06579053Phase 1
- Pharmacogenetics of Torasemide and Spironolactone in Hypertension TreatmentCompletedNCT06413082Phase 3
- Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1CompletedNCT06004830Phase 2
- Dapagliflozin With or Without Spironolactone for HFpEFCompletedNCT05676684Phase 2/3
- Fibrosis and the FontanCompletedNCT04901975Phase 1/2
- Non-Responsive Diabetic Macular Edema and SpironolactoneWithdrawnNCT04853355Phase 4
- Spironolactone and Dexamethasone in Patients Hospitalized With COVID-19Status unknownNCT04826822Phase 3
- Spironolactone in the Treatment of Heart FailureTerminatedNCT04727073Phase 3
- Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart FailureStatus unknownNCT04618601Phase 4
- Comparative Effectiveness Study of Spironolactone Versus Doxycycline for AcneActive, not recruitingNCT04582383Phase 4
- Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early DementiaCompletedNCT04522739Phase 4
- Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled StudyStatus unknownNCT04465123Phase 3
- The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart FailureStatus unknownNCT04455178Phase 4
- BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalizationStatus unknownNCT04424134Phase 3
- Mineralocorticoid Antagonism to Stop Progression of Atrial Fibrillation (MONITOR-AF) StudyStatus unknownNCT04327232Phase 2
- Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea PatientsWithdrawnNCT04205136Phase 4
- Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR TrialWithdrawnNCT04190433Phase 2
- Spironolactone for Hidradenitis SuppurativaWithdrawnNCT04100083Phase 4
- Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis PatientsStatus unknownNCT03953950Phase 4
- Spironolactone for the Treatment of MelasmaWithdrawnNCT03953209Phase 1
- Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial FibrillationActive, not recruitingNCT03929718Early Phase 1
- Adjuvant Anti-Mineralocorticoid-Receptor Treatment in Anti-VEGF Refractory Neovascular Age-Related Macular DegenerationCompletedNCT03744767Phase 2
- Spironolactone Versus Indapamide in Obese and Hypertensive PatientsStatus unknownNCT03626506Not applicable
- Spironolactone and Perioperative Atrial Fibrillation Occurrence in Cardiac Surgery Patients.Status unknownNCT03551548Phase 3
- Hypoglycemia and Autonomic Nervous System Function-BCompletedNCT03429946Phase 4
- Spironolactone Therapy in Chronic Stable Right HF TrialCompletedNCT03344159Phase 4
- Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.CompletedNCT03334682Phase 3
- The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary AngiographyCompletedNCT03329443Phase 2
- Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis PatientsCompletedNCT03314493Phase 3
- Exploring Mechanisms and Morphology of QT Interval ProlongationCompletedNCT03291145Not applicable
- Spironolactone on Acute Kidney Injury in Critically Ill PatientsStatus unknownNCT03206658Phase 3
- The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 DiabetesCompletedNCT03174288Not applicable
- Colchicine and Spironolactone in Patients with MI / SYNERGY Stent RegistryCompletedNCT03048825Phase 3
- Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal DiseaseCompletedNCT03020303Phase 3