Acne Vulgaris clinical trials
The registry lists 791 studies for Acne Vulgaris across more than 10 countries. 94 are recruiting or about to start. 741 of them are mainly about Acne Vulgaris (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 1,012 studies for Acne Vulgaris. How that becomes 790 here
This page counts the studies the registry files under Acne Vulgaris, and those it files under no condition that list Acne Vulgaristhemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,012Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −222Match it another way5 name it in the title, 1 in a keyword, and 216 by a synonym or other text the search reads.
- 790The count on this page8 of them list Acne Vulgaris in their own words; the registry filed them under no condition.
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Who runs them
Galderma R&D (45) · Stiefel, a GSK Company (29) · Bausch Health Americas, Inc. (27) · Taro Pharmaceuticals USA (21) · Assiut University (18) · Cosmetique Active International (14) · GlaxoSmithKline (13) · Novan, Inc. (13)
What is being tested here
Drugs under test in Acne Vulgaris studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Clascoterone | 5 | 5 | 19 |
| Isotretinoin | 4 | 3 | 23 |
| Doxycycline | 2 | 2 | 12 |
| Clindamycin | 1 | 9 | 34 |
| Metformin | 1 | 0 | 4 |
| TVB-2640 | 1 | 3 | 4 |
| Sarecycline | 1 | 3 | 4 |
| Spironolactone | 1 | 1 | 3 |
| Nitrosomonas eutropha D23 | 1 | 1 | 3 |
| Botulinum toxin type A | 1 | 1 | 3 |
Drug classes tested here Mineralocorticoid receptor antagonists (MRAs) 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Split-Face Comparative Study of Mono Threads Versus Combination With Plasma Gel for the Treatment of Post-Acne Scars · Phase 3 · Tanta University
- Dec 2026A Long-term Safety and Efficacy Study of N-Acetyl-GED-0507-34-LEVO Gel 5%, in Subjects With Acne Vulgaris (GEDACNE-LT) · Phase 3 · PPM Services S.A.
- Dec 2026A Study to Compare the Efficacy, Safety and Pharmacokinetics of Trifarotene 50 mcg/g Cream in Chinese Subjects With Acne Vulgaris · Phase 3 · Galderma R&D
- Feb 2027Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne Vulgaris · Phase 3 · Eurofarma Laboratorios S.A.
- May 2027Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris. · Phase 3 · Cairo University
- Aug 2027Phase 3 Study of Denifanstat in Participants With Moderate to Severe Acne (AURORA) · Phase 3 · Sagimet Biosciences Inc.
- Sep 2027Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients · Phase 3 · Centre Hospitalier Universitaire de Nice
- Nov 2026Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis · Nanjing First Hospital, Nanjing Medical University
- Dec 2026Photodynamic Therapy With Topical Application of a Zn(II) Phthalocyanine (RLP068/Cl) and Red Light for the Treatment of Moderate-to-severe Acne Vulgaris · Università degli Studi di Brescia
- Dec 2026Evaluation of Juläine (TM) for the Treatment of Atrophic Facial Acne Scars · Nordberg Medical AB
Who these studies take
Of the 47 Acne Vulgaris studies recruiting now, 17 (36%) set no upper age limit and 29 (62%) stop at 75 or younger. 21 (45%) take children under 18. 5 (11%) are for women only and 0 (0%) for men only; 17 (36%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (9%) | 4 (9%) |
| 18 | 44 (94%) | 40 (85%) |
| 30 | 43 (91%) | 40 (85%) |
| 40 | 39 (83%) | 35 (74%) |
| 50 | 28 (60%) | 27 (57%) |
| 65 | 21 (45%) | 21 (45%) |
| 75 | 18 (38%) | 18 (38%) |
| 85 | 18 (38%) | 18 (38%) |
Across all 791 studies, recruiting or not: 63% stop at 75 or younger and 61% at 65; 58% take children; 7% are for women only and 2% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Acne Vulgaris studies take
Of 62 phase 3 interventional studies under Acne Vulgaris, half reached primary completion within 13 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 5 mo2–10 · 51 studies | 4 mo1–7 · 44 studies | — |
| Phase 1/2 | 16 mo6–22 · 13 studies | — | — |
| Phase 2 | 9 mo6–15 · 37 studies | 9 mo6–15 · 29 studies | — |
| Phase 3 | 13 mo10–17 · 62 studies | 13 mo10–17 · 53 studies | — |
| Phase 4 | 11 mo7–16 · 45 studies | — | — |
| Interventional, no phase | 9 mo4–18 · 120 studies | 9 mo3–19 · 62 studies | 9 mo4–17 · 58 studies |
| Observational | 10 mo3–13 · 37 studies | 8 mo3–11 · 22 studies | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered8
- Clinical Evaluation of an Oil-Balancing Facial Sunscreen With Topical TretinoinNov 12, 2026NCT07932288
- Safety, Tolerability, and Clinical Effectiveness of Adapalene/Clindamycin Phosphate Gel (Klenzit®-C) in Vietnamese Patients With Mild to Moderate Acne VulgarisNov 5, 2026NCT07918001
- Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris.Nov 5, 2026NCT07919886
- Comparing Nadifloxacin Plus Tretinoin Versus Clindamycin Plus Tretinoin Creams for Mild-to-Moderate AcneNov 4, 2026NCT07915648
- A Split-Face Comparative Study of Mono Threads Versus Combination With Plasma Gel for the Treatment of Post-Acne ScarsOct 29, 2026NCT07903012
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- Evaluating a Brightening Serum for Post-Inflammatory HyperpigmentationOct 27, 2026NCT07896486
- Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne VulgarisOct 20, 2026NCT07883538
- Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial AcneOct 19, 2026NCT07881315
Studies
Recruiting first, then most recently updated. Showing 50 of 791. Browse all 791 → or search them.
- Clinical Evaluation of an Oil-Balancing Facial Sunscreen With Topical TretinoinEnrolling by invitationNCT07932288Phase 41 country
- Phase 3 Study of Denifanstat in Participants With Moderate to Severe Acne (AURORA)RecruitingNCT07863193Phase 31 country
- Safety, Tolerability, and Clinical Effectiveness of Adapalene/Clindamycin Phosphate Gel (Klenzit®-C) in Vietnamese Patients With Mild to Moderate Acne VulgarisRecruitingNCT07918001Phase 41 country
- Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris.Not yet recruitingNCT07919886Phase 31 country
- Comparing Nadifloxacin Plus Tretinoin Versus Clindamycin Plus Tretinoin Creams for Mild-to-Moderate AcneRecruitingNCT07915648Phase 41 country
- Evaluating a Brightening Serum for Post-Inflammatory HyperpigmentationNot yet recruitingNCT07896486Not applicable1 country
- A Split-Face Comparative Study of Mono Threads Versus Combination With Plasma Gel for the Treatment of Post-Acne ScarsEnrolling by invitationNCT07903012Phase 2/31 country
- Collection of Samples From Subjects With Various Skin Conditions and Healthy VolunteersRecruitingNCT059949761 country
- Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne VulgarisRecruitingNCT06905210Phase 31 country
- Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne VulgarisRecruitingNCT07883538Not applicable1 country
- Phase 1 Study to Evaluate the Safety, Tolerability, PK, and PD of TVB-3567 in Healthy Participants With or Without AcneRecruitingNCT06989840Phase 12 countries
- Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial AcneNot yet recruitingNCT07881315Phase 41 country
- Study to Determine Efficacy, Safety, and Tolerability of B244 as a Topical Spray in Subjects With Moderate to Severe Acne VulgarisNot yet recruitingNCT07866105Phase 2
- Evaluation of Juläine (TM) for the Treatment of Atrophic Facial Acne ScarsRecruitingNCT07058883Not applicable1 country
- Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With IsotretinoinRecruitingNCT078341381 country
- Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color PatientsRecruitingNCT06447480Phase 32 countries
- Demodex Mites in Acne Patients and Herbal Extract SusceptibilityNot yet recruitingNCT07845149
- Safety of the Acne mRNA Vaccine in Adolescents 12 to 17 Years of Age With Moderate to Severe AcneNot yet recruitingNCT07756957Phase 2
- Prevalence of Polyendocrine Metabolic Ovarian Syndrome in Patients Diagnosed With Acne Vulgaris in Sohag University HospitalRecruitingNCT078223601 country
- AVAVA MIRIA General UseRecruitingNCT06868615Not applicable1 country
- The Impact of Baseline Hormonal Profiles (DHEAS, FSH, LH) on Treatment Response to Systemic Isotretinoin in Adult Female Patients With Acne VulgarisRecruitingNCT078185251 country
- Radiofrequency Treatment Versus Topical Therapy for Facial Acne VulgarisRecruitingNCT07805655Not applicable1 country
- Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe AcneRecruitingNCT06316297Phase 1/24 countries
- Safety and Efficacy of Skincare Products for Managing Mild to Moderate Acne in Individuals With Sensitive SkinRecruitingNCT07749469Not applicable1 country
- Study to Assess Safety, Pharmacokinetics, and Treatment Effect of CabtreoRecruitingNCT07524946Phase 41 country
- Clinical Observation of Skin Condition in Patients With Acne Vulgaris Using Ubiquinol, Pomegranate Peel Extract, Ceramide, and Salicylic Acid EmulsionNot yet recruitingNCT07735169
- Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Participants With Mild AcneRecruitingNCT07013747Phase 1/21 country
- A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in DermatologyNot yet recruitingNCT07481019Not applicable
- A Clinical Trial to Investigate the Efficacy and Safety of GenLabs' Social Renew on Improving Acne Symptoms and Skin Repair Among Healthy AdultsNot yet recruitingNCT07127523Not applicable1 country
- Comparison of Topical Clascoterone and Adapalene for Mild Acne VulgarisNot yet recruitingNCT07673094Early Phase 1
- Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne VulgarisNot yet recruitingNCT07639073Phase 41 country
- Weekly Isotretinoin vs Tetracycline for Moderate AcneRecruitingNCT06225570Early Phase 11 country
- Role of Akkermansia Muciniphila in Acne VulgarisNot yet recruitingNCT06992154Early Phase 1
- Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept TrialRecruitingNCT07341087Not applicable1 country
- Photodynamic Therapy With Topical Application of a Zn(II) Phthalocyanine (RLP068/Cl) and Red Light for the Treatment of Moderate-to-severe Acne VulgarisNot yet recruitingNCT07089368Not applicable
- Sebum Metabolomics and Lipidomics for Clinical ApplicationsNot yet recruitingNCT07549828Not applicable
- Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.RecruitingNCT07544251Phase 41 country
- Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic InflammationNot yet recruitingNCT07539129Not applicable1 country
- Creation of a Monocentric Cohort of Patients Treated for Acne at the Nantes University HospitalRecruitingNCT034651501 country
- Topical Application of Engineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating for AcneRecruitingNCT07366229Phase 21 country
- Efficacy of 0.5% Topical Timolol Eye Drops in the Treatment of Post-Inflammatory Erythema Following Acne VulgarisRecruitingNCT07474883Early Phase 11 country
- Comparative Effectiveness of Clindamycin-Retinoid, Clindamycin-Retinoid-Dexamethasone, and 10% SM-hUCMSC Secretome Gel in the Improvement of Mild-to-Moderate Acne VulgarisNot yet recruitingNCT07504822Phase 1/21 country
- Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face StudyNot yet recruitingNCT07473895Phase 21 country
- 1% Clascoterone Cream for the Treatment Acne VulgarisNot yet recruitingNCT07457294Phase 3
- A Study to Evaluate Efficacy and Safety of HB0043 in Aadult Patients With Moderate to Severe Acne Vulgaris.Not yet recruitingNCT07449156Phase 1/21 country
- Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel)Not yet recruitingNCT07421804Not applicable
- Non-interventional Translational Study in Mild, Moderate and Severe Acne PatientsNot yet recruitingNCT07411638
- Metronidazole 2% Gel Versus Clindamycin 1% Gel for Moderate Acne VulgarisNot yet recruitingNCT07392047Phase 4
- Safety, Efficacy and Pharmacokinetic Characteristics of KR230109 Cream in Facial Acne VulgarisNot yet recruitingNCT07345390Phase 2
- Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris StudyRecruitingNCT07056673Not applicable1 country