Drug
Metoprolol clinical trials
Also written Lopressor and Toprol-XL.
- studies test it
- 139
- open now
- 12
- in phase 3
- 23
- first study started
- 1995
Keep track of what changes. Save the Metoprolol studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
137 studies that test it; most in 2018 (10); 1 more planned to start later
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 5 |
| 2002 | 5 |
| 2003 | 2 |
| 2004 | 3 |
| 2005 | 3 |
| 2006 | 4 |
| 2007 | 7 |
| 2008 | 7 |
| 2009 | 7 |
| 2010 | 8 |
| 2011 | 6 |
| 2012 | 8 |
| 2013 | 5 |
| 2014 | 6 |
| 2015 | 4 |
| 2016 | 9 |
| 2017 | 6 |
| 2018 | 10 |
| 2019 | 2 |
| 2020 | 4 |
| 2021 | 3 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 6 |
| 2025 | 5 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 28
- Phase 2
- 18
- Phase 3
- 23
- Phase 4
- 55
- No phase
- 22
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 35 · Other 104
AstraZeneca (5) · Saniona (4) · IPCA Laboratories Ltd. (3) · Mayo Clinic (3) · Creighton University (3) · University of Calgary (2) · Boehringer Ingelheim (2) · Eli Lilly and Company (2)
Often tested with
Tested in the same studies.
Nebivolol (17) · Carvedilol (13) · Midazolam (9) · Diltiazem (7) · Bisoprolol (6) · Verapamil (6) · Caffeine (6) · Omeprazole (6)
Studies
Open first, then newest update. How each study uses Metoprolol is read from its arms, and is right about nine times in ten.
Testing it · 139
- Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic ScoreRecruitingPhase 4University of MichiganNCT07490067Written as Metoprolol Succinate
- CSP #2026 - Beta Blocker Dialyzability on Cardiovascular OutcomesRecruitingPhase 3VA Office of Research and DevelopmentNCT05931276Written as Metoprolol Succinate
- Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal SurgeriesRecruitingPhase 4Damanhour Teaching HospitalNCT04914234Written as Metoprolol Succinate Oral Tablet
- Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)Not yet recruitingPhase 4Muhammad Ali JavedNCT07706075Written as Metoprolol tartrate
- Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal IntubationNot yet recruitingPhase 4Fujian Provincial HospitalNCT07597564Written as Metoprolol (MET)
- Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNot applicableEnhanced Emirates LimitedNCT07568574Written as Metoprolol
- Pharmacological Intervention to Prevent NOAF After TAVRNot yet recruitingNot applicableShanghai East HospitalNCT07519161Written as Metoprolol succinate
- Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery DiseaseEnrolling by invitationPhase 2/3Gødstrup HospitalNCT07268170Written as Metoprolol tartrate
- Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCARecruitingPhase 4VZW Cardiovascular Research Center AalstNCT06864234Written as Metoprolol Tartrate
- Early Beta Blocker Administration in STEMI Patients With SCAI B StatusRecruitingNot applicableTel-Aviv Sourasky Medical CenterNCT06967194Written as Metoprolol (MET)
- Determination of Drug Levels for Pharmacotherapy of Heart FailureNot yet recruitingPhase 4University Hospital OstravaNCT06035978Written as Metoprolol
- The Efficacy and Safety of Metoprolol as add-on Treatment to Standard of Care in Preventing Cardiomyopathy in Patients With DMDRecruitingPhase 3Medical University of GdanskNCT05066633Written as Metoprolol Succinate
- Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)Active, not recruitingPhase 4Madeleine PuissantNCT06569212Written as Metoprolol
- Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate ControlTerminatedPhase 4CAMC Health SystemNCT02025465Written as Metoprolol
- Beta-blockers to Patients With Chronic Obstructive Pulmonary DiseaseCompletedPhase 4Ole Frobert, MD, PhDNCT03566667Written as Metoprolol
- Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN)TerminatedPhase 3Consorcio Centro de Investigación Biomédica en Red (CIBER)NCT05847517Written as Metoprolol Injection
- Melatonin vs Metoprolol or Dexmedetomidine to Improve Surgical Field in FESSCompletedNot applicableZagazig UniversityNCT07568873Written as Metoprolol (MET)
- BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEFCompletedPhase 4University of PennsylvaniaNCT04434664Written as Metoprolol Succinate
- Metoprolol to Reduce Perioperative Myocardial InjuryCompletedPhase 3University of ChicagoNCT03138603Written as Metoprolol Tartrate
- Rate Control in Patients With Atrial FibrillationCompletedNot applicableNational Taiwan University HospitalNCT04513509Written as Atenolol, Bisoprolol, Metoprolol, Nebivolol, Propranolol, Diltiazem, Verapamil, digoxin
See all 139 studies that test Metoprolol →
Given in every arm · 24 — Metoprolol is usual care beside what is tested
- Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve ProlapseRecruitingPhase 3Oslo University HospitalNCT05631730Written as Metoprolol
- An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 SubstratesCompletedPhase 1SanofiNCT06686628Written as Metoprolol
- Weak Pulse at Yang and Wiry Pulse at Yin TheoryCompletedNot applicableXikun LiNCT07378228Written as Metoprolol Succinate Extended-Release Tablets
- Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic DermatitisCompletedEarly Phase 1AmgenNCT05891119Written as Metoprolol
- Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4CompletedPhase 1LEO PharmaNCT03556592Written as Metoprolol
- Effect of Evolocumab on Coronary AtherosclerosisCompletedPhase 3Cedars-Sinai Medical CenterNCT03689946Written as Metoprolol
- Metformin's Effect on Drug Metabolism in Patients With Type 2 DiabetesTerminatedPhase 1University of Southern DenmarkNCT04504045Written as Metoprolol
- Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and CarvedilolStatus unknownPhase 4Natalia Valadares de MoraesNCT04049786Written as Metoprolol 100 mg for CYP2D6 phenotyping
- Efficacy and Safety of Metoprolol Tartrate Tablets Combined With Chinese Traditional Medicine on Premature Ventricular Complex.CompletedPhase 4Xuanwu Hospital, BeijingNCT05008250Written as metoprolol tartrate
- Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total OcclusionsStatus unknownNot applicableBeijing Anzhen HospitalNCT04744571Written as aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor
- Efficacy and Safety of Sotalol in Children With ArrhythmiaStatus unknownPhase 4Shengjing HospitalNCT03895411Written as betaloc
- Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)CompletedPhase 1Merck Sharp & Dohme LLCNCT01337674Written as Metoprolol
- Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive PatientsCompletedPhase 4University of Texas Southwestern Medical CenterNCT01501929Written as Metoprolol succinate
- Dabigatran in an Interaction Probe Drug CocktailCompletedPhase 1Turku University HospitalNCT02361619Written as Metoprolol
- A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With TicagrelorCompletedPhase 1Vastra Gotaland RegionNCT03441412Written as Metoprolol
- Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPDCompletedPhase 4VA Greater Los Angeles Healthcare SystemNCT03370835Written as Metoprolol succinate ER
- Curative Effect Evaluation of Danlou Tablet on Coronary Artery Disease Not Amenable to RevascularizationStatus unknownPhase 4Jun LiNCT03072082Written as Metoprolol Tartrate Tab 25 MG
- Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to RevascularizationStatus unknownPhase 4Jun LiNCT03072121Written as Metoprolol Tartrate Tab 25 MG
- Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)CompletedPhase 1Regeneron PharmaceuticalsNCT02647086Written as Metoprolol
- Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)CompletedPhase 4Mikael LantzNCT01458600Written as Metoprolol
Showing 20 of 24.
As the comparator · 29 — what is tested is compared with Metoprolol
- BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic CardiomyopathyRecruitingPhase 3Braveheart Bio, Inc.NCT07755904Written as Metoprolol
- SMART-VERAPAF: Self-MAnagement and Random Therapy With VERApamil or Metoprolol in Paroxysmal Atrial FibrillationNot yet recruitingPhase 4Martini Hospital GroningenNCT07445789Written as metoprolol 100 mg slow-release tablet
- Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter DefibrillatorRecruitingPhase 4University of RochesterNCT06964464Written as Metoprolol Succinate
- Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCMCompletedPhase 3CytokineticsNCT05767346Written as Metoprolol succinate (50 mg, 100 mg, 150 mg and 200 mg)
- Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen OvaleCompletedPhase 2Chinese Academy of Medical Sciences, Fuwai HospitalNCT05546320Written as Metoprolol 25mg
- Sympathetic and Vascular Function in Takotsubo SyndromeCompletedPhase 1/2Danderyd HospitalNCT05768542Written as Metoprolol Injection
- Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart FailureCompletedPhase 2ARCA Biopharma, Inc.NCT01970501Written as metoprolol succinate
- Heart Rate Controller in Computed Tomography Coronary AngiographyStatus unknownPhase 4Mahidol UniversityNCT05261464Written as Metoprolol tartrate
- Evaluation of the Long-term Safety and Tolerability of Metoprolol Versus Nebivolol in Patients With HypertensionCompletedPhase 3Mylan Bertek PharmaceuticalsNCT00142584Written as Metoprolol (MET)
- Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy IndividualsTerminatedPhase 4Bayside HealthNCT00825123Written as Metoprolol
- Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for HypertensionTerminatedPhase 3Forest LaboratoriesNCT00547300Written as Metoprolol ER
- Clonidine to Prevent Implantable Cardiovertor Defibrillator FiringWithdrawnNot applicableJames MartinsNCT00585871Written as metoprolol
- COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With HypertensionCompletedPhase 3GlaxoSmithKlineNCT00273052Written as metoprolol succinate
- Radiofrequency Ablation of Symptomatic Frequent Ventricular Premature Complexes in Pediatric PopulationStatus unknownPhase 2/3Meshalkin Research Institute of Pathology of CirculationNCT02772354Written as Metoprolol
- Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the ArteriesCompletedPhase 2/3University of ChicagoNCT00829296Written as Metoprolol
- A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart FailureWithdrawnPhase 4The AlfredNCT00384566Written as Metoprolol
- Comparison of Bisoprolol With Metoprolol Succinate Sustained-release on Heart Rate and Blood Pressure in Hypertensive PatientsCompletedPhase 4Merck KGaA, Darmstadt, GermanyNCT01508325Written as Metoprolol
- Nebivolol in the Supine Hypertension of Autonomic FailureCompletedNot applicableVanderbilt UniversityNCT01044693Written as metoprolol tartrate 50 mg
- Tight Hemodynamic Control in Patients Who Are Chronically on MetoprololTerminatedPhase 4University Health Network, TorontoNCT01404767Written as Metoprolol
- Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood PressureCompletedPhase 3Thomas Jefferson UniversityNCT01499134Written as Metoprolol succinate
Showing 20 of 29.
Codes
What other systems call Metoprolol · ClinicalTrials.gg INT007827
- MeSH (NLM) D008790MetoprololConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) GEB06NHM23METOPROLOLConfirmed FDA, NLM, Wikidata
- RxNorm 6918Confirmed FDA, Wikidata
- Wikidata Q409468(RS)-metoprololConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61845MetoprololOne source FDA
- DrugBank DB00264One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008790 | Metoprolol | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | GEB06NHM23 | METOPROLOL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6918 | — | Confirmed FDA, Wikidata |
| Wikidata | Q409468 | (RS)-metoprolol | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61845 | Metoprolol | One source FDA |
| DrugBank | DB00264 | — | One source Wikidata |
Also registered as metoprolol succinate (UNII TH25PD4CCB · RxNorm 221124) and metoprolol tartrate (UNII W5S57Y3A5L · RxNorm 203191).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.