Drug
Guanfacine clinical trials
Also written Intuniv, Tenex and SPD503.
- studies test it
- 66
- open now
- 6
- in phase 3
- 12
- first study started
- 1994
Keep track of what changes. Save the Guanfacine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Development codes
Combined with it in one product
Studies by the year they started
66 studies that test it; most in 2010 (6)
| Year | Studies |
|---|---|
| 1994 | 1 |
| 1995 | 1 |
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 1 |
| 2006 | 3 |
| 2007 | 1 |
| 2008 | 5 |
| 2009 | 4 |
| 2010 | 6 |
| 2011 | 6 |
| 2012 | 5 |
| 2013 | 1 |
| 2014 | 6 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 1 |
| 2018 | 1 |
| 2019 | 6 |
| 2020 | 3 |
| 2021 | 1 |
| 2022 | 1 |
| 2023 | 1 |
| 2025 | 1 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 8
- Phase 2
- 18
- Phase 3
- 12
- Phase 4
- 21
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 15 · Other 51
Shire (15) · Yale University (11) · Icahn School of Medicine at Mount Sinai (4) · Vanderbilt University Medical Center (3) · New York State Psychiatric Institute (3) · Imperial College London (2) · Stanford University (2) · Massachusetts General Hospital (2)
Often tested with
Tested in the same studies.
Methylphenidate (4) · Lisdexamfetamine (3) · Hydrochlorothiazide (2) · Lidocaine (1) · Amphetamine (1) · Modafinil (1) · Clonidine (1) · Aspirin, Dipyridamole Drug Combination (1)
Studies
Open first, then newest update. How each study uses Guanfacine is read from its arms, and is right about nine times in ten.
Testing it · 66
- Guanfacine and Cromolyn Sodium for POTS: The DBPOTS TrialNot yet recruitingEarly Phase 1Johns Hopkins UniversityNCT07757555Written as Guanfacine (GFC)
- Treating Young Children With Attention Deficit Hyperactivity DisorderRecruitingPhase 4Children's Hospital Medical Center, CincinnatiNCT07300956Written as Guanfacine (GUA)
- Guanfacine for Alcohol Use Disorder (AUD)RecruitingPhase 2Indiana UniversityNCT06629259Written as Guanfacine Extended Release (XR)
- ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in DepressionRecruitingPhase 2Stanford UniversityNCT06408246Written as Guanfacine
- Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use DisordersRecruitingPhase 2Yale UniversityNCT03764098Written as Guanfacine ER
- Guanfacine Extended-release for Adolescents With Cannabis UseRecruitingPhase 2OrygenNCT05957848Written as Guanfacine Extended Release Oral Tablet
- Experimental fMRI Study of Guanfacine and Lisdexamfetamine in ADHD AdolescentsCompletedNot applicableKing's College LondonNCT03333668Written as Guanfacine Extended Release Oral Tablet
- Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and ToleranceTerminatedPhase 4Massachusetts General HospitalNCT01681264Written as Guanfacine 1mg
- Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)TerminatedNot applicableMassachusetts General HospitalNCT02192398Written as Guanfacine
- A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)CompletedPhase 4ShireNCT04085172Written as Guanfacine hydrochloride (TAK-503)
- Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine StudyCompletedPhase 2Vanderbilt University Medical CenterNCT04742673Written as Guanfacine
- Efficacy and Safety Eval of Guanfacine Hydrochloride in Combination With Psychostimulants in Adults (18-65).CompletedPhase 4Rochester Center for Behavioral MedicineNCT02141113Written as Guanfacine Hydrochloride
- The Effect of Guanfacine on Delirium in Critically Ill PatientsCompletedPhase 3University of Alabama at BirminghamNCT04578886Written as Guanfacine
- Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal NeuropathyCompletedPhase 2Vanderbilt University Medical CenterNCT03865940Written as Guanfacine
- The BIomarker Guided (BIG) Study for DepressionCompletedPhase 4Stanford UniversityNCT04181736Written as Guanfacine Tablets
- Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi SyndromeCompletedPhase 4Maimonides Medical CenterNCT05657860Written as Guanfacine Extended Release
- Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)CompletedPhase 1/2Stony Brook UniversityNCT03137082Written as Guanfacine XR 3mgs/daily
- Noradrenergic Add-on Therapy With GuanfacineActive, not recruitingPhase 3Imperial College LondonNCT03116126Written as Guanfacine
- Guanfacine to Improve Substance Use Outcomes in WomenCompletedPhase 2Yale UniversityNCT03980184Written as Guanfacine
- An fMRI Study of Stimulant vs. Non-Stimulant Treatment of ADHDTerminatedNot applicableNew York State Psychiatric InstituteNCT02259517Written as Guanfacine
See all 66 studies that test Guanfacine →
Given in every arm · 2 — Guanfacine is usual care beside what is tested
- Combining Varenicline and Guanfacine for Smoking CessationCompletedPhase 2Yale UniversityNCT04198116Written as Guanfacine ER
- Efficacy of GXR as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHDCompletedPhase 4JPM van Stralen Medicine ProfessionalNCT01985581Written as Guanfacine extended release
As the comparator · 2 — what is tested is compared with Guanfacine
- DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant HypertensionCompletedPhase 3Gilead SciencesNCT00389779Written as Guanfacine
- DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant HypertensionTerminatedPhase 3Gilead SciencesNCT00389675Written as Guanfacine
Codes
What other systems call Guanfacine · ClinicalTrials.gg INT008528
- MeSH (NLM) D016316GuanfacineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 30OMY4G3MKGUANFACINEConfirmed FDA, NLM, Wikidata
- RxNorm 40114Confirmed FDA, Wikidata
- Wikidata Q5613599guanfacineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61779GuanfacineOne source FDA
- DrugBank DB01018One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D016316 | Guanfacine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 30OMY4G3MK | GUANFACINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 40114 | — | Confirmed FDA, Wikidata |
| Wikidata | Q5613599 | guanfacine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61779 | Guanfacine | One source FDA |
| DrugBank | DB01018 | — | One source Wikidata |
Also registered as guanfacine hydrochloride (UNII PML56A160O · RxNorm 203142).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.