Metabolic Syndrome clinical trials
The registry lists 2,117 studies for Metabolic Syndrome across more than 10 countries. 347 are recruiting or about to start. 1,054 of them are mainly about Metabolic Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 6,059 studies for Metabolic Syndrome. How that becomes 2,115 here
This page counts the studies the registry files under Metabolic Syndrome, and those it files under no condition that list Metabolic Syndromethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 6,059Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −28List Metabolic Syndrome as a condition, but the registry did not file them under itMost often written as “Abdominal Obesity Metabolic Syndrome” (7), “Cardiovascular-kidney-metabolic Syndrome” (7), and “Cardiovascular Kidney Metabolic Syndrome” (3). The registry filed them under other conditions only, most often Abdominal obesity metabolic syndrome (9) and Cardiovascular Diseases (8).
- −3,916Match it another way175 name it in the title, 9 in a keyword, and 3,732 by a synonym or other text the search reads.
- 2,115The count on this page19 of them list Metabolic Syndrome in their own words; the registry filed them under no condition.
Get an email when these change. Save the Metabolic Syndrome studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
Laval University (24) · Cairo University (21) · University of Copenhagen (20) · University of Toronto (17) · National Taiwan University Hospital (16) · University of Aarhus (14) · Massachusetts General Hospital (14) · Lund University (14)
What is being tested here
Drugs under test in Metabolic Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Semaglutide | 6 | 4 | 8 |
| Empagliflozin | 4 | 4 | 7 |
| Tirzepatide | 3 | 0 | 3 |
| Berberine | 2 | 3 | 10 |
| Probiotic | 2 | 0 | 5 |
| Telmisartan | 1 | 2 | 6 |
| Liraglutide | 1 | 1 | 5 |
| Anastrozole | 1 | 1 | 4 |
| Dapagliflozin | 1 | 2 | 2 |
| Thioctic Acid | 1 | 1 | 2 |
Drug classes tested here GLP-1 receptor agonists 9 open · SGLT2 inhibitors 5 open · Angiotensin receptor blockers (ARBs) 1 open · Integrase inhibitors 1 open · NSAIDs 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Apr 2027Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome · Phase 3 · Georgios Papadakis
- Aug 2027Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) · Phase 3 · Northwell Health
- Aug 2027Alpha-Lipoic Acid Added to Dapagliflozin and Insulin Resistance in Type 2 Diabetes · Phase 3 · Fayoum University
- Nov 2026Metabolic Syndrome in Patients with Knee Osteoarthritis · Assiut University
- Nov 2026Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy · Kazakh Academy of Nutrition
- Nov 2026Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes · Ball State University
- Nov 2026Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform · Signos Inc
- Nov 2026MPV as a Predictor for ACS in Patients With MASLD · Sohag University
- Nov 2026Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects · Charite University, Berlin, Germany
- Nov 2026Plasma Biomarkers of Muscle Metabolism During Exercise to the Assessment of Insulin Resistance in CKD Dialysis Patients · University Hospital, Montpellier
Who these studies take
Of the 231 Metabolic Syndrome studies recruiting now, 68 (29%) set no upper age limit and 135 (58%) stop at 75 or younger. 20 (9%) take children under 18. 22 (10%) are for women only and 8 (3%) for men only; 80 (35%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 10 (4%) | 9 (4%) |
| 18 | 146 (63%) | 136 (59%) |
| 30 | 174 (75%) | 164 (71%) |
| 40 | 186 (81%) | 179 (77%) |
| 50 | 181 (78%) | 177 (77%) |
| 65 | 171 (74%) | 165 (71%) |
| 75 | 111 (48%) | 107 (46%) |
| 85 | 79 (34%) | 76 (33%) |
Across all 2,117 studies, recruiting or not: 66% stop at 75 or younger and 46% at 65; 10% take children; 9% are for women only and 7% for men only; 41% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Metabolic Syndrome studies take
Of 32 phase 4 interventional studies under Metabolic Syndrome, half reached primary completion within 32 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 26 mo9–53 · 17 studies | — | — |
| Phase 2 | 29 mo18–58 · 31 studies | — | 30 mo26–62 · 28 studies |
| Phase 4 | 32 mo13–57 · 32 studies | — | — |
| Interventional, no phase | 20 mo9–40 · 675 studies | 19 mo11–37 · 50 studies | 20 mo9–41 · 625 studies |
| Observational | 42 mo18–106 · 160 studies | — | 43 mo18–106 · 149 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting4
- AI-Driven Metabolic Cohort in Overweight/Obese Chinese AdultsOct 27, 2026NCT07584330
- Multi-omics Dissection of Gut Microbiome Engraftment During FMTOct 26, 2026NCT06992453
- Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.Oct 21, 2026NCT07554326
- Preoperative Oral Carbohydrate Loading and Gastrointestinal Recovery After Bariatric Surgery in Metabolic SyndromeOct 15, 2026NCT07822763
Results posted1
- Semaglutide 2.4 mg in Patients With Poor Weight-lossOct 26, 2026NCT05073835
Stopped1
- Benefit of a Hospital Intervention in Patients With Hepatic SteatosisWithdrawnOct 28, 2026NCT06394206
Newly registered7
- Alpha-Lipoic Acid Added to Dapagliflozin and Insulin Resistance in Type 2 DiabetesNov 12, 2026NCT07934225
- Fulvic Acid Supplementation and Metabolic SyndromeNov 10, 2026NCT07927283
- Asprosin and miRNA Expression in Young Women With Metabolic SyndromeNov 4, 2026NCT07917364
- Fecal Microbiota Transplantation (FMT) to Slow Biological AgingNov 3, 2026NCT07912164
- Retrospective Analysis of Erectile Dysfunction (ED) Patients Based on a Large-scale Clinical DatabaseNov 3, 2026NCT07913477
Show 2 moreShow fewer
- Targeted Health Dialogues for Individuals With Psychosis Spectrum DisordersOct 22, 2026NCT07888894
- Effect of Resistance Exercises on Serum IGF-1 Levels in Knee OsteoarthritisOct 22, 2026NCT07890155
Studies
Recruiting first, then most recently updated. Showing 50 of 2,117. Browse all 2,117 → or search them.
- Effects of Meal Macronutrients on Postprandial LipidsNot yet recruitingNCT07313787Phase 21 country
- Long-Term Follow-Up of Survivors of Pediatric Cushing DiseaseRecruitingNCT038319581 country
- Alpha-Lipoic Acid Added to Dapagliflozin and Insulin Resistance in Type 2 DiabetesNot yet recruitingNCT07934225Phase 31 country
- LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL LoweringRecruitingNCT06865885Phase 41 country
- Fulvic Acid Supplementation and Metabolic SyndromeRecruitingNCT07927283Not applicable1 country
- Truway Diagnostic Tools in Primary CareEnrolling by invitationNCT07209527Early Phase 11 country
- The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial FunctionRecruitingNCT05972564Phase 1/21 country
- Our Voices Matter: Intervention for Depression in YouthRecruitingNCT07216326Not applicable1 country
- Asprosin and miRNA Expression in Young Women With Metabolic SyndromeRecruitingNCT079173641 country
- Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)RecruitingNCT07625332Phase 2/31 country
- Fecal Microbiota Transplantation (FMT) to Slow Biological AgingNot yet recruitingNCT07912164Not applicable
- Human Cerebrovascular Blood Flow and Sex Differences in Metabolic SyndromeNot yet recruitingNCT07218653Early Phase 11 country
- AI-Driven Metabolic Cohort in Overweight/Obese Chinese AdultsRecruitingNCT075843301 country
- iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) +Optimized Lifestyle Intervention (OLI) vs Sham + OLI for Weight LossRecruitingNCT07237750Not applicable1 country
- Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)RecruitingNCT07111208Not applicable1 country
- Multi-omics Dissection of Gut Microbiome Engraftment During FMTRecruitingNCT06992453Not applicable1 country
- Study of the Effect of Innate on the Inflammatory Response to EndotoxinRecruitingNCT011434801 country
- Immersive Virtual Reality Training for Improving Cognition in Adults With Metabolic SyndromeRecruitingNCT07040748Not applicable1 country
- Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood PressureRecruitingNCT05903950Not applicable1 country
- Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.RecruitingNCT07554326Not applicable1 country
- Targeted Health Dialogues for Individuals With Psychosis Spectrum DisordersNot yet recruitingNCT07888894Not applicable
- Effect of Resistance Exercises on Serum IGF-1 Levels in Knee OsteoarthritisRecruitingNCT07890155Not applicable1 country
- Biometabolic Outcomes After Weight Loss Surgery: An Individualized ApproachEnrolling by invitationNCT04841057Not applicable1 country
- Impact GLP-1 Agonists Following BariatricRecruitingNCT06132477Phase 41 country
- Assessing Trauma-related Links Between Affective and Metabolic SystemsNot yet recruitingNCT07862712Phase 41 country
- Preoperative Oral Carbohydrate Loading and Gastrointestinal Recovery After Bariatric Surgery in Metabolic SyndromeRecruitingNCT07822763Not applicable1 country
- Effects of Intermittent Dietary Restriction on Cardiometabolic Risk in School-aged ChildrenRecruitingNCT06500078Not applicable1 country
- HAPA-based Intervention in Adults With Metabolic Syndrome and Chronic Kidney DiseaseRecruitingNCT06715735Not applicable1 country
- MASLD in Type 2 Diabetes in Primary Care - a Follow-up StudyEnrolling by invitationNCT073121361 country
- AI Chatbot-Enabled ePRO Monitoring and Nurse-Led Self-Management for Early-Stage Cardiovascular-Kidney-Metabolic SyndromeNot yet recruitingNCT07577284Not applicable1 country
- Spinal Cord Injury Model Systems (SCIMS) - Education ModuleRecruitingNCT06003686Not applicable1 country
- A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular EventsRecruitingNCT06112418Not applicable1 country
- Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes MellitusNot yet recruitingNCT07797036Phase 2/31 country
- Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I)RecruitingNCT07710274Not applicable1 country
- A Clinical Study on Using Multimodal Ultrasound to Assess Muscle Mass in Metabolic DiseasesRecruitingNCT078360881 country
- Metabolic Syndrome Resposne to Dietary Limitations in Familial Mediterranean Fever in AdolescentsRecruitingNCT07833007Not applicable1 country
- Metaboic Syndrome and Fatty Liver in Celiac Disease Females: Reponse to Exercise in AdolescentsRecruitingNCT07832994Not applicable1 country
- Metabolic Syndrome and PrediabetesRecruitingNCT072438211 country
- Mazdutide for Weight Management and Gout in Adults With ObesityNot yet recruitingNCT07824895Phase 4
- A Prospective Cohort Study on Patient With Obesity Undergoing Weight ChangeEnrolling by invitationNCT072391671 country
- Duodenal pulsENDO for Suboptimally Controlled Type II Diabetes Mellitus and Steatotic Liver DiseaseRecruitingNCT07390422Not applicable1 country
- Extended-Release Tacrolimus Following Liver TransplantationRecruitingNCT05242315Phase 41 country
- Patients With Type 2 DiabetesRecruitingNCT072450821 country
- Duodenal-jejunal Bypass Sleeve (DJBS) for Obesity and Metabolic SyndromeRecruitingNCT07675122Not applicable1 country
- Effects of Nitraria Retusa Infusion on Clozapine-induced Metabolic Side EffectsRecruitingNCT07817069Not applicable1 country
- Effects of Quercetin on Cardiometabolic OutcomesRecruitingNCT06230861Not applicable1 country
- Longevity Metrics AI/ML Development StudyRecruitingNCT078086191 country
- Health Ahead Comparative Effectiveness StudyRecruitingNCT07669168Not applicable1 country
- 100-Year Human Aging StudyRecruitingNCT075637771 country
- Human Observatory StudyRecruitingNCT076467821 country