An Early Phase 1 interventional study of Hydrocortisone Acetate (CORT) and Epinephrine Sulfate (EPI) in Depression, sponsored by Stanford University. Withdrawn. Open to participants aged 21 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-10-06.
Sponsored by Stanford University · Early Phase 1, Interventional, and Basic science
This study investigates the effects of two hormones called epinephrine and cortisol on how the brain processes emotional material using functional MRI to measure brain activity. The study hopes to learn how epinephrine and cortisol affect the brain differently in depressed and non-depressed individuals.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
Browse Depression studies →Stanford University is the lead sponsor of 2,117 studies on the registry; 425 are open to participants now.
Of its 259 completed or terminated interventional studies of FDA-regulated products, 197 (76%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Healthy participant will receive cortisol pill and epinephrine infusion
Drug: Hydrocortisone Acetate (CORT) · Drug: Epinephrine Sulfate (EPI)
Healthy participant will receive placebo pill and epinephrine infusion
Drug: Epinephrine Sulfate (EPI) · Drug: Placebo (PLB)
Depressed participant will receive cortisol pill and epinephrine infusion
Drug: Hydrocortisone Acetate (CORT) · Drug: Epinephrine Sulfate (EPI)
Depressed participant will receive placebo pill and epinephrine infusion
Drug: Epinephrine Sulfate (EPI) · Drug: Placebo (PLB)
Participants will receive a single dose of hydrocortisone at a dosage of 0.65 mg/kg
Also known as: Cortef
Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min
Also known as: Adrenalin
Participants will receive a placebo
Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging
Time frame: 2 hours
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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Stanford University