Out-of-Hospital Cardiac Arrest clinical trials
The registry lists 314 studies for Out-of-Hospital Cardiac Arrest across more than 10 countries. 93 are recruiting or about to start. 273 of them are mainly about Out-of-Hospital Cardiac Arrest (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Status
Who runs them
National Taiwan University Hospital (15) · Emergency Medical Services, Capital Region, Denmark (12) · Karolinska Institutet (10) · Seoul National University Hospital (10) · Assistance Publique - Hôpitaux de Paris (8) · Region Skane (7) · Far Eastern Memorial Hospital (6) · University of Washington (6)
What is being tested here
Drugs under test in Out-of-Hospital Cardiac Arrest studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Epinephrine | 2 | 1 | 2 |
| Xenon | 1 | 1 | 2 |
| Naloxone | 1 | 0 | 1 |
| Isoproterenol | 1 | 0 | 1 |
| Esketamine | 1 | 0 | 1 |
| Ascorbic Acid | 0 | 0 | 2 |
| Sodium Nitrite | 0 | 1 | 2 |
| Dexamethasone | 0 | 1 | 1 |
| Olanzapine | 0 | 1 | 1 |
| Insulin | 0 | 0 | 1 |
Drug classes tested here Bronchodilators 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027The Danish Out-of-Hospital Cardiac Arrest Study · Phase 3 · Christian Hassager
- Dec 2026Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE) · Helsinki University Central Hospital
- Dec 2026PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) · Singapore General Hospital
- Dec 2026Drone Delivery of Automated External Defibrillators to Lay Users (DAEDALUS): A Proof of Concept Study · University of Surrey
- Dec 2026Validity of ICU Clinician's Appraisal of Proportionality in CPR · University Hospital, Ghent
- Dec 2026Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest · Queen Mary University of London
- Dec 2026Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy · Region Skane
- Dec 2026Artificial Intelligence Cerebral Gray-white Matter Ratio Module Usage in Hsinchu District Hsinchu District Using an Artificial Intelligence Cerebral Gray-white Matter Ratio Module · National Taiwan University Hospital
- Dec 2026The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region · Azienda Usl di Bologna
- Dec 2026Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore. · Singapore General Hospital
Who these studies take
Of the 66 Out-of-Hospital Cardiac Arrest studies recruiting now, 46 (70%) set no upper age limit and 13 (20%) stop at 75 or younger. 8 (12%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 7 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (9%) | 6 (9%) |
| 18 | 62 (94%) | 62 (94%) |
| 30 | 65 (98%) | 65 (98%) |
| 40 | 65 (98%) | 65 (98%) |
| 50 | 65 (98%) | 65 (98%) |
| 65 | 60 (91%) | 60 (91%) |
| 75 | 56 (85%) | 56 (85%) |
| 85 | 49 (74%) | 49 (74%) |
Across all 314 studies, recruiting or not: 12% stop at 75 or younger and 5% at 65; 19% take children; 0% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Out-of-Hospital Cardiac Arrest studies take
Of 95 interventional studies with no phase under Out-of-Hospital Cardiac Arrest, half reached primary completion within 34 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 34 mo19–57 · 95 studies | — | 34 mo19–57 · 93 studies |
| Observational | 46 mo20–75 · 69 studies | — | 46 mo20–75 · 69 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting1
- Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCANov 9, 2026NCT06692075
Newly registered6
- Compression-Only Versus Standard Basic Life Support Training in Nursing StudentsNov 4, 2026NCT07915778
- Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac ArrestNov 2, 2026NCT07909642
- The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac ArrestOct 29, 2026NCT07905482
- Cardiac Arrest - Ultrasound Detection of Occult PerfusionOct 27, 2026NCT07897370
- Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac ArrestOct 26, 2026NCT07895771
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- Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac ArrestOct 20, 2026NCT07882589
Studies
Recruiting first, then most recently updated. Showing 50 of 314. Browse all 314 → or search them.
- Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)RecruitingNCT05376267Not applicable5 countries
- Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCARecruitingNCT06692075Not applicable1 country
- Compression-Only Versus Standard Basic Life Support Training in Nursing StudentsNot yet recruitingNCT07915778Not applicable1 country
- Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac ArrestNot yet recruitingNCT07909642Not applicable1 country
- Cardiac Arrest - Ultrasound Detection of Occult PerfusionRecruitingNCT078973701 country
- Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac ArrestRecruitingNCT07895771Not applicable1 country
- Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac ArrestRecruitingNCT061223371 country
- Epinephrine Dose: Optimal Versus Standard Evaluation TrialRecruitingNCT03826524Phase 41 country
- Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain InjuryRecruitingNCT077822161 country
- Cerebral Oximetry in Management of Post Cardiac ArrestRecruitingNCT07829887Not applicable1 country
- Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2RecruitingNCT06025123Not applicable8 countries
- Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingNCT06251609Phase 21 country
- Mean Arterial Pressure After Out-of-hospital Cardiac ArrestRecruitingNCT05486884Not applicable1 country
- Ventilation Performance and Feedback Simulation TrialRecruitingNCT07352709Not applicable1 country
- MEdical Treatment in Idiopathic Ventricular Fibrillation PatientsRecruitingNCT07405229Phase 41 country
- Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?RecruitingNCT06824961Not applicable1 country
- Increasing Law Enforcement Application of Automated External Defibrillators (AED)s for Cardiac ArrestEnrolling by invitationNCT07649616Not applicable1 country
- Core Temperature in Patients With OHCARecruitingNCT049767121 country
- Resuscitative TEE Collaborative RegistryRecruitingNCT049725261 country
- Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac ArrestRecruitingNCT06776549Not applicable1 country
- The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)RecruitingNCT07002294Not applicable1 country
- Korean Cardiac Arrest Research ConsortiumRecruitingNCT032229991 country
- Initial Double Sequential External Defibrillation in Out of Hospital Cardiac ArrestRecruitingNCT06672159Not applicable1 country
- Skeletal Muscle Mass on Prognosis and Recovery in Clinical TrialEnrolling by invitationNCT07034170Not applicable1 country
- Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac ArrestRecruitingNCT06473207Not applicable1 country
- Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028Not yet recruitingNCT07622082
- Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest AlertsNot yet recruitingNCT07607808Not applicable1 country
- FEMART-1 Pilot StudyRecruitingNCT07596446Not applicable1 country
- The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna RegionNot yet recruitingNCT075895041 country
- Pain After Cardiac Arrest and Resuscitation (PAINCARE)RecruitingNCT075647781 country
- Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival StudyRecruitingNCT03981107Not applicable2 countries
- Abdominal Aortic Tourniquet Application for Non-Traumatic Out-of-Hospital Cardiac ArrestNot yet recruitingNCT07573566Not applicable1 country
- PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)RecruitingNCT07421882Not applicable1 country
- Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to FamiliesRecruitingNCT068448511 country
- Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.Not yet recruitingNCT07042061Not applicable
- Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation CareRecruitingNCT07239908Phase 2/31 country
- Enhanced Community First Responder System Evaluation in SingaporeRecruitingNCT06530433Not applicable1 country
- Simulation and Feasibility Study of Drone-Delivered AED for Out-of-Hospital Cardiac ArrestNot yet recruitingNCT07508774Not applicable1 country
- Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled TrialNot yet recruitingNCT07479836Not applicable1 country
- Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological OutcomeNot yet recruitingNCT07442071Phase 31 country
- Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.RecruitingNCT074389381 country
- The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia CountriesRecruitingNCT055451761 country
- Drone Delivery of Automated External Defibrillators to Lay Users (DAEDALUS): A Proof of Concept StudyRecruitingNCT074308131 country
- The AIR-CPR Study: AI-Guided Chest CompressionsRecruitingNCT074317101 country
- Early Double Sequential Defibrillation in Out of Hospital Cardiac ArrestRecruitingNCT07174986Phase 2/33 countries
- German Cardiac Arrest RegistryRecruitingNCT051421241 country
- On Scene ECPR in OstravaRecruitingNCT07374289Not applicable1 country
- The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.RecruitingNCT06939335Phase 32 countries
- Prehospital ECPR in Moravia Silesia RegionRecruitingNCT070410861 country
- the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)Not yet recruitingNCT07258823Not applicable