Drug
Cyclobenzaprine clinical trials
Also written Flexeril and AMRIX®.
- studies test it
- 42
- open now
- 5
- in phase 3
- 17
- first study started
- 2003
Keep track of what changes. Save the cyclobenzaprine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
40 studies that test it; most in 2013 (5)
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2006 | 1 |
| 2009 | 1 |
| 2010 | 3 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 5 |
| 2014 | 1 |
| 2015 | 4 |
| 2016 | 2 |
| 2017 | 3 |
| 2018 | 3 |
| 2019 | 3 |
| 2020 | 1 |
| 2022 | 4 |
| 2025 | 2 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 9
- Phase 2
- 10
- Phase 3
- 17
- Phase 4
- 5
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 30 · Other 12
Tonix Pharmaceuticals, Inc. (24) · Neurana Pharmaceuticals, Inc. (1) · Endeavor Health (1) · Takeda (1) · Montefiore Medical Center (1) · Sandoz (1) · Stony Brook University (1) · University of Alabama at Birmingham (1)
Often tested with
Tested in the same studies.
Oxycodone-acetaminophen (1) · Ibuprofen (1) · Pseudoephedrine (1) · Tamsulosin (1) · Imipramine (1) · Solifenacin (1) · Acetaminophen (1) · Ketorolac (1)
Studies
Open first, then newest update. How each study uses cyclobenzaprine is read from its arms, and is right about nine times in ten.
Testing it · 42
- Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)RecruitingPhase 2University of North Carolina, Chapel HillNCT06636786Written as Cyclobenzaprine HCl
- Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis ReleaseRecruitingPhase 4Northwestern UniversityNCT07840183Written as Cyclobenzaprine
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)RecruitingPhase 2Tonix Pharmaceuticals, Inc.NCT07621237Written as TNX-102 SL
- Cyclobenzaprine for Postoperative Pain in Minimally Invasive HysterectomyNot yet recruitingPhase 4Christiana Care Health ServicesNCT07664956Written as Cyclobenzaprine
- Comparing Adjuvant Treatments for High Tone Pelvic Floor DysfunctionRecruitingPhase 2/3University of MichiganNCT07404397Written as Cyclobenzaprine
- A Single-Dose, Randomized, Open-Label, 2-Way Crossover Study to Evaluate the Dose-Proportionality, Safety, and Tolerability of TNX-102 SL (Cyclobenzaprine HCl Sublingual Tablets) in Healthy Japanese and Chinese SubjectsCompletedPhase 1Tonix Pharmaceuticals, Inc.NCT07464535Written as TNX-102 SL
- A Phase 1, Open-Label, Parallel-Group, Single-Dose Study To Compare The Pharmakokinetics Of TNX-102 SL (Cyclobenzaprine Hydrochloride Sublingual Tablet) In Non-Elderly Versus Elderly ParticipantsActive, not recruitingPhase 1Tonix Pharmaceuticals, Inc.NCT07413367Written as TNX-102 SL Tablet
- Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With FibromyalgiaTerminatedPhase 3Tonix Pharmaceuticals, Inc.NCT02829814Written as TNX-102 SL Tablet, 2.8 mg
- A 3-Month Open-Label Safety and Efficacy Study of TNX-102 SL Tablets in Fibromyalgia PatientsCompletedPhase 3Tonix Pharmaceuticals, Inc.NCT02589275Written as TNX-102 SL Tablet 2.8 mg
- A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgiaCompletedPhase 3Tonix Pharmaceuticals, Inc.NCT02436096Written as TNX-102 SL Tablet, 2.8mg
- Open Label Extension Safety and Efficacy Study of TNX-102 SL Tablets in Military Related PTSD and Related ConditionsCompletedPhase 2Tonix Pharmaceuticals, Inc.NCT02421679Written as TNX-102 SL
- A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSDTerminatedPhase 3Tonix Pharmaceuticals, Inc.NCT03841773Written as TNX-102 SL
- 12-Week Open-Label Extension Study of TNX-102 SL in PTSD PatientsTerminatedPhase 3Tonix Pharmaceuticals, Inc.NCT03110575Written as TNX-102 SL
- A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSDCompletedPhase 3Tonix Pharmaceuticals, Inc.NCT03508700Written as TNX-102 SL 5.6 mg
- A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily in Patients With FibromyalgiaCompletedPhase 3Tonix Pharmaceuticals, Inc.NCT05273749Written as TNX-102 SL Tablet, 5.6 mg
- Cyclobenzaprine Extended Release (ER) for FibromyalgiaTerminatedPhase 4State University of New York - Upstate Medical UniversityNCT01041495Written as cyclobenzaprine ER (AMRIX)
- A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 InfectionCompletedPhase 2Tonix Pharmaceuticals, Inc.NCT05472090Written as TNX-102 SL
- Safety and Efficacy Study of TNX-102 SL in Subjects With Military-Related PTSD and Related ConditionsCompletedPhase 2Tonix Pharmaceuticals, Inc.NCT02277704Written as TNX-102 SL
- Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSDTerminatedPhase 3Tonix Pharmaceuticals, Inc.NCT03062540Written as TNX-102 SL
- A Phase 3 Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With FibromyalgiaCompletedPhase 3Tonix Pharmaceuticals, Inc.NCT04508621Written as TNX-102 SL
See all 42 studies that test cyclobenzaprine →
Given in every arm · 2 — cyclobenzaprine is usual care beside what is tested
- Multimodal Analgesia Effect on Post Surgical PatientCompletedPhase 4University of California, DavisNCT04240626Written as Flexeril Oral Product
- Analysis of the Effects of the Osteopathic Manipulative Treatment in Carriers of Temporomandibular DisordersCompletedNot applicableInstituto Brasileiro de OsteopatiaNCT02974166Written as Cyclobenzaprine Hydrochloride
As the comparator · 6 — what is tested is compared with cyclobenzaprine
- Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar ExtractionTerminatedPhase 3Apsen Farmaceutica S.A.NCT03127592Written as Cyclobenzaprine
- Effects of Tolperisone on Measures of Drowsiness and Cognitive FunctionCompletedPhase 1Neurana Pharmaceuticals, Inc.NCT04407377Written as Cyclobenzaprine Hydrochloride 10 MG
- Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine in Osteomuscular TreatmentCompletedPhase 3EMSNCT03025113Written as Cyclobenzaprine
- Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular TreatmentCompletedPhase 3EMSNCT02862977Written as Cyclobenzaprine with caffeine
- Comparative Bioavailability of Sublingual TNX-102, Oral and Intravenous Cyclobenzaprine in Healthy AdultsCompletedPhase 1Tonix Pharmaceuticals, Inc.NCT01634412Written as Cyclobenzaprine Tablet
- Comparative Pharmacokinetics and Safety of TNX-102 SL Tablets and Cyclobenzaprine Oral Tablet in Healthy AdultsCompletedPhase 1Tonix Pharmaceuticals, Inc.NCT01689259Written as Cyclobenzaprine tablets
Codes
What other systems call cyclobenzaprine · ClinicalTrials.gg INT002300
- MeSH (NLM) C004704cyclobenzaprineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 69O5WQQ5TICYCLOBENZAPRINEConfirmed FDA, NLM, Wikidata
- RxNorm 21949Confirmed FDA, Wikidata
- Wikidata Q5198674cyclobenzaprineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C28947CyclobenzaprineOne source FDA
- DrugBank DB00924One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C004704 | cyclobenzaprine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 69O5WQQ5TI | CYCLOBENZAPRINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 21949 | — | Confirmed FDA, Wikidata |
| Wikidata | Q5198674 | cyclobenzaprine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C28947 | Cyclobenzaprine | One source FDA |
| DrugBank | DB00924 | — | One source Wikidata |
Also registered as cyclobenzaprine hydrochloride (UNII 0VE05JYS2P · RxNorm 52101).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.