Post-Acute COVID-19 Syndrome clinical trials
The registry lists 605 studies for Post-Acute COVID-19 Syndrome across more than 10 countries. 201 are recruiting or about to start. 500 of them are mainly about Post-Acute COVID-19 Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
ClinicalTrials.gov finds 713 studies for Post-Acute COVID-19 Syndrome. How that becomes 604 here
This page counts the studies the registry files under Post-Acute COVID-19 Syndrome, and those it files under no condition that list Post-Acute COVID-19 Syndromethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 713Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −3List Post-Acute COVID-19 Syndrome as a condition, but the registry did not file them under itMost often written as “Long COVID Syndrome” (2) and “Long COVID Fatigue” (1). The registry filed them under other conditions only, most often Myocarditis (1) and Heart Failure (1).
- −106Match it another way41 name it in the title, 3 in a keyword, and 62 by a synonym or other text the search reads.
- 604The count on this page5 of them list Post-Acute COVID-19 Syndrome in their own words; the registry filed them under no condition.
Get an email when these change. Save the Post-Acute COVID-19 Syndrome studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
VA Office of Research and Development (11) · Icahn School of Medicine at Mount Sinai (10) · Duke University (8) · Charite University, Berlin, Germany (7) · Karolinska Institutet (6) · Kanecia Obie Zimmerman (5) · Massachusetts General Hospital (5) · University of Alberta (5)
What is being tested here
Drugs under test in Post-Acute COVID-19 Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Naltrexone | 2 | 1 | 4 |
| Metformin | 2 | 2 | 2 |
| Taurine | 2 | 1 | 2 |
| Maraviroc | 2 | 1 | 2 |
| Nogapendekin alfa inbakicept | 2 | 0 | 2 |
| Remdesivir | 1 | 0 | 3 |
| Sirolimus | 1 | 2 | 2 |
| Fluvoxamine | 1 | 2 | 2 |
| Immunoglobulins, Intravenous | 1 | 0 | 2 |
| Immunoglobulin G | 1 | 0 | 2 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open · JAK inhibitors 2 open · Corticosteroids 1 open · Stimulants 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID · Phase 3 · Wes Ely
- Dec 2026Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID Fibrosis · Phase 3 · University of Chicago
- Dec 2026Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study · Phase 3 · Douglas D. Fraser
- Dec 2026A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID · Phase 3 · HealthBio, Inc.
- Dec 2026Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 · Phase 3 · Icahn School of Medicine at Mount Sinai
- Jun 2027A Study of Human Umbilical Cord Blood (REGENECYTE) Infusion in Patients With Post-COVID Condition · Phase 3 · StemCyte, Inc.
- Nov 2026Evaluation of the Effectiveness of Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital · Centre Hospitalier Universitaire de la Réunion
- Nov 2026SuperCAP Program to Improve Cognition and Daily Functioning in Post-COVID-19 Condition · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
- Nov 2026Antiviral Clinical Trial for Long Covid-19 · Icahn School of Medicine at Mount Sinai
- Nov 2026Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain. · Fundación Universidad Católica de Valencia San Vicente Mártir
Who these studies take
Of the 145 Post-Acute COVID-19 Syndrome studies recruiting now, 70 (48%) set no upper age limit and 53 (37%) stop at 75 or younger. 15 (10%) take children under 18. 2 (1%) are for women only and 0 (0%) for men only; 39 (27%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (8%) | 12 (8%) |
| 18 | 134 (92%) | 132 (91%) |
| 30 | 136 (94%) | 134 (92%) |
| 40 | 137 (94%) | 135 (93%) |
| 50 | 139 (96%) | 137 (94%) |
| 65 | 133 (92%) | 132 (91%) |
| 75 | 97 (67%) | 97 (67%) |
| 85 | 79 (54%) | 79 (54%) |
Across all 605 studies, recruiting or not: 35% stop at 75 or younger and 24% at 65; 8% take children; 1% are for women only and <1% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Post-Acute COVID-19 Syndrome studies take
Of 63 phase 2 interventional studies under Post-Acute COVID-19 Syndrome, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 17 mo12–23 · 63 studies | — | 17 mo12–24 · 46 studies |
| Interventional, no phase | 16 mo7–27 · 244 studies | — | 16 mo8–28 · 233 studies |
| Observational | 27 mo14–39 · 105 studies | — | 27 mo17–39 · 98 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting3
- Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility StudyNov 5, 2026NCT07874217
- SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionOct 28, 2026NCT07597902
- Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.Oct 15, 2026NCT05780450
Results posted1
- RECOVER-ENERGIZE Platform ProtocolNov 5, 2026NCT06404047
Newly registered6
- Rimonabant for Cognitive Impairment in People With Post-COVID-19 SyndromeNov 12, 2026NCT07930637
- The Study of Brave-LC LDN Treatment TrialNov 4, 2026NCT07916259
- Study of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination SyndromeOct 27, 2026NCT07899346
- Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic DiseasesOct 22, 2026NCT07888673
- Intensive Home-based Transcranial Direct Current Stimulation for Long COVIDOct 19, 2026NCT07880171
Show 1 moreShow fewer
- Cognitive Impairment and Return to Work in Long COVIDOct 19, 2026NCT07881029
Studies
Recruiting first, then most recently updated. Showing 50 of 605. Browse all 605 → or search them.
- Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)Not yet recruitingNCT07388550Phase 11 country
- Rimonabant for Cognitive Impairment in People With Post-COVID-19 SyndromeNot yet recruitingNCT07930637Phase 21 country
- Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS)RecruitingNCT07798570Not applicable1 country
- Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2Enrolling by invitationNCT05350774Phase 21 country
- Immunoadsorption in Autoimmune Long COVIDRecruitingNCT07316127Phase 21 country
- Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility StudyRecruitingNCT07874217Not applicable1 country
- The Study of Brave-LC LDN Treatment TrialNot yet recruitingNCT07916259Phase 31 country
- SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionRecruitingNCT07597902Phase 21 country
- Fareon Open Label Device Clinical TrialEnrolling by invitationNCT07600320Not applicable1 country
- Study of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination SyndromeNot yet recruitingNCT07899346Phase 2
- DAOIB for the Treatment of Brain FogRecruitingNCT05764538Phase 21 country
- Effect of Hi-OxSR for the Treatment of Post COVID ConditionRecruitingNCT06928506Not applicable1 country
- Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)RecruitingNCT04978571Not applicable1 country
- Taurine Supplementation in Adolescents With Post-COVID ConditionNot yet recruitingNCT07682402Phase 1/2
- LIFT: Life Improvement TrialRecruitingNCT06366724Phase 21 country
- Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.RecruitingNCT05780450Not applicable1 country
- IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 ConditionRecruitingNCT07197138Not applicable1 country
- Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug StudyRecruitingNCT06928272Phase 37 countries
- PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVIDRecruitingNCT07661862Not applicable1 country
- SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)RecruitingNCT07021794Phase 21 country
- Heat thErapy And mobiLity in COVID-19 SurvivorsRecruitingNCT06928116Not applicable1 country
- Long-Term Study of COVID-19 Infection and Long COVIDRecruitingNCT077815011 country
- Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVIDRecruitingNCT06631287Phase 31 country
- A Study to Examine Anktiva for the Treatment of COVID-19.RecruitingNCT07123727Phase 21 country
- Taurine Supplementation in Long COVIDRecruitingNCT06721949Phase 2/31 country
- Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute InfectionRecruitingNCT065774671 country
- Development of Voice Biomarkers of Frequent COVID-19 and Long Covid-related Symptoms Based on Data From Users of the Long COVID Companion AppRecruitingNCT071569941 country
- Evaluation of the Effectiveness of Breathing Control Technique on Long COVID Symptoms at the Reunion University HospitalRecruitingNCT05851859Not applicable1 country
- SuperCAP Program to Improve Cognition and Daily Functioning in Post-COVID-19 ConditionRecruitingNCT07530757Not applicable1 country
- RCT of Mind-body in Long COVID and Myalgic EncephalomyelitisRecruitingNCT06933173Not applicable1 country
- Long-Covid-19 Alleviation Through Learning Mindfulness StudyRecruitingNCT07140094Not applicable1 country
- Fatigue Investigation Using Digital OutcomesRecruitingNCT077830741 country
- Sonlicromanol in Post-COVIDRecruitingNCT07298005Phase 21 country
- Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)RecruitingNCT077700221 country
- PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)RecruitingNCT06920628Phase 11 country
- Micro-choice-based Intervention for Multicausal FatigueRecruitingNCT07726082Not applicable1 country
- Five-year Follow-up After Sars-CoV-2 Infection: Prevalence and Evolution of Post-acute Sequalae of COVID-19 (PASC)Not yet recruitingNCT07766512
- Long-term COVID and RehabilitationRecruitingNCT05373043Not applicable1 country
- CD19-B Cell Depletion in PAIS-ME/CFS PatientsNot yet recruitingNCT07724834Phase 21 country
- Long-term Impact of Infection With Novel Coronavirus (COVID-19)RecruitingNCT043621501 country
- Transcranial Direct Current Stimulation for Long COVID Brain Fog and FatigueNot yet recruitingNCT07709234Not applicable
- Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE)Not yet recruitingNCT07714213Phase 21 country
- Magnetic Resonance Analysis of Neural Inflammatory Factors and External StimulationRecruitingNCT06940609Phase 21 country
- Cognitive Rehabilitation Therapy for COVID-19Enrolling by invitationNCT06086379Not applicable1 country
- Kisspeptin to Quantify GnRH Neuronal Function in Health and DiseaseRecruitingNCT07224490Phase 11 country
- Fatigue in Long COVIDNot yet recruitingNCT07697261Not applicable
- A Pilot Randomized Controlled Trial of Homeopathic Treatment for Long COVIDNot yet recruitingNCT07694232Not applicable1 country
- Dietary Intervention to Mitigate Post-Acute COVID-19 SyndromeRecruitingNCT05977179Not applicable1 country
- Covid-19 Long Immunité IMagerie (CLIIM)RecruitingNCT06528171Not applicable1 country
- Water-based Activity to Enhance Recovery in Long COVID-19RecruitingNCT06142253Not applicable1 country