Muscle Spasticity clinical trials
The registry lists 621 studies for Muscle Spasticity across more than 10 countries. 127 are recruiting or about to start. 197 of them are mainly about Muscle Spasticity (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
ClinicalTrials.gov finds 923 studies for Muscle Spasticity. How that becomes 621 here
This page counts the studies the registry files under Muscle Spasticity, and those it files under no condition that list Muscle Spasticitythemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 923Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −302Match it another way5 name it in the title, 3 in a keyword, and 294 by a synonym or other text the search reads.
- 621The count on this page
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Status
Who runs them
Riphah International University (19) · Allergan (17) · Ipsen (15) · Chang Gung Memorial Hospital (12) · Jazz Pharmaceuticals (10) · Kessler Foundation (8) · Vanderbilt University (7) · Shirley Ryan AbilityLab (7)
What is being tested here
Drugs under test in Muscle Spasticity studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Combined Antagonistic Muscle Magnetic Stimulation and Selective Periferal Neurotomy to Improve Results on Spasticity · Juan Carlos M. Andreani MD
- Nov 2026Spinal Cord Stimulation for Children With Cerebral Palsy · Martin Piazza
- Nov 2026The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke) · National University Health System, Singapore
- Dec 2026Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient. · University of Alberta
- Dec 2026Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy · Universitaire Ziekenhuizen KU Leuven
- Dec 2026The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure. · Eva Ponten
- Dec 2026Effect of Treatment Dairy for Spasticity · Copenhagen University Hospital, Rigshospitalet
- Dec 2026Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity · University of Mississippi Medical Center
- Dec 2026Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning · Medical University of South Carolina
- Dec 2026Muscle-tendon Pathology and Metabolic Dysregulation in CP · University of Graz
Who these studies take
Of the 88 Muscle Spasticity studies recruiting now, 29 (33%) set no upper age limit and 47 (53%) stop at 75 or younger. 34 (39%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 11 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 28 (32%) | 28 (32%) |
| 18 | 65 (74%) | 65 (74%) |
| 30 | 58 (66%) | 58 (66%) |
| 40 | 58 (66%) | 58 (66%) |
| 50 | 60 (68%) | 60 (68%) |
| 65 | 55 (63%) | 55 (63%) |
| 75 | 47 (53%) | 47 (53%) |
| 85 | 35 (40%) | 35 (40%) |
Across all 621 studies, recruiting or not: 46% stop at 75 or younger and 33% at 65; 29% take children; <1% are for women only and <1% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Muscle Spasticity studies take
Of 16 phase 3 interventional studies under Muscle Spasticity, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 33 mo16–57 · 16 studies | — | — |
| Interventional, no phase | 15 mo7–34 · 234 studies | — | 15 mo6–37 · 226 studies |
| Observational | 32 mo9–124 · 59 studies | — | 23 mo9–… · 54 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted1
- Short-Burst Interval Treadmill Training Cerebral PalsyOct 29, 2026NCT04026295
Stopped1
Newly registered6
- Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple SclerosisOct 27, 2026NCT07897760
- Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord InjuryOct 26, 2026NCT07894991
- Addressing Spasticity and Motor Function With Epidural Spinal Cord StimulationOct 22, 2026NCT07890558
- Powered Exoskeleton-Assisted Walking in Persons With Spinal Cord InjuryOct 20, 2026NCT07884591
- Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION)Oct 15, 2026NCT07875868
Show 1 moreShow fewer
- Co-contraction and Corticoreticular Excitability in Spinal Cord InjuryOct 14, 2026NCT07872839
Studies
Recruiting first, then most recently updated. Showing 50 of 621. Browse all 621 → or search them.
- Intrathecal Baclofen and Pediatric DystoniaRecruitingNCT06606574Not applicable1 country
- Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower ExtremitiesRecruitingNCT07303582Phase 41 country
- Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord InjuryRecruitingNCT07894991Phase 21 country
- Early Botulinum Toxin for Muscle Stiffness Reduction in First-Time Stroke Patients: Improving Recovery and IndependenceNot yet recruitingNCT06811142Early Phase 11 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis SpasticityRecruitingNCT06782490Phase 27 countries
- Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple SclerosisNot yet recruitingNCT07897760Not applicable2 countries
- Effect of Treatment Dairy for SpasticityEnrolling by invitationNCT033849271 country
- Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord InjuryRecruitingNCT07501429Phase 11 country
- Addressing Spasticity and Motor Function With Epidural Spinal Cord StimulationRecruitingNCT07890558Not applicable1 country
- Co-contraction and Corticoreticular Excitability in Spinal Cord InjuryEnrolling by invitationNCT07872839Not applicable1 country
- At Home Use of Stimulation Suits for Managing MS SymptomsRecruitingNCT07202195Not applicable2 countries
- Effect of Neural Constraints on Movement in StrokeRecruitingNCT06666673Early Phase 11 country
- Leg Stretching Using an Exoskeleton on Demand for People With SpasticityRecruitingNCT05926596Not applicable1 country
- A Pilot Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants With Post-Stroke Spasticity (The STIPS Study)RecruitingNCT07704840Phase 21 country
- rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCTRecruitingNCT06128746Not applicable1 country
- Spinal Cord Stimulation for Poststroke SpasticityRecruitingNCT07744659Not applicable1 country
- Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down ConditioningRecruitingNCT05094362Not applicable1 country
- Outcomes of Neurosurgical Tone ManagementRecruitingNCT078177451 country
- The Effect of Whole-Body Vibration Therapy Following Botulinum Toxin A Injection on Spasticity and Balance in Stroke PatientsRecruitingNCT07286435Not applicable1 country
- The Use of Photobiomodulation in the Treatment of Spasticity After Stroke.RecruitingNCT07784231Phase 1/21 country
- Robot Aided Rehabilitation - InterventionRecruitingNCT02359253Not applicable1 country
- Robot Aided Rehabilitation - Multi-joint EvaluationsRecruitingNCT023598121 country
- Intermittent Theta-Burst Stimulation for Lower-Limb Spasticity and Pain in Multiple SclerosisNot yet recruitingNCT07786506Not applicable1 country
- Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic PainRecruitingNCT076390601 country
- Dorsal Root Electrical Stimulation in Children With Cerebral PalsyRecruitingNCT07715006Not applicable1 country
- A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.RecruitingNCT04752774Phase 1/214 countries
- Extracorporeal Shock Wave Therapy in Botulinum Toxin-Treated Patients With Post-Stroke Ankle Plantar Flexor SpasticityNot yet recruitingNCT07695038Not applicable1 country
- Collagenase Injection for Spasticity ManagementNot yet recruitingNCT07693569Early Phase 11 country
- Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)RecruitingNCT05518188Phase 1/21 country
- Functional Balance Intervention in Multiple SclerosisRecruitingNCT06341023Not applicable1 country
- Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb SpasticityRecruitingNCT07447934Not applicable1 country
- Goal Attainment Scaling in Upper Limb Spasticity TreatmentRecruitingNCT04975646Not applicable1 country
- Immediate Effects On Gait and Spasticity After The Use Of Passive Kinesiotherapy Equipment In The Lower Limbs Of Neurological PatientsEnrolling by invitationNCT06696040Not applicable1 country
- Spasticity in SCI Following Acute Intermittent HypoxiaRecruitingNCT07583498Not applicable1 country
- Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic SpasticityNot yet recruitingNCT07583277Not applicable
- tDCS and Bi-manual Training in Cerebral PalsyNot yet recruitingNCT07573865Not applicable1 country
- Comparative Study of LoKomat® Exoskeleton VS C-Mill® Treadmill for Gait Recovery in Rehabilitation.RecruitingNCT07230470Not applicable1 country
- Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic EquinovarusRecruitingNCT06767631Not applicable1 country
- Muscle-tendon Pathology and Metabolic Dysregulation in CPRecruitingNCT063309221 country
- Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular HarmRecruitingNCT069917251 country
- Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral PalsyNot yet recruitingNCT02199015Not applicable2 countries
- Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient.RecruitingNCT05226637Not applicable1 country
- Spinal Cord Stimulation for Children With Cerebral PalsyRecruitingNCT07516067Not applicable1 country
- Effectiveness of TMS on Spasticity and Balance for Patients With MSRecruitingNCT07451600Not applicable1 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor ImpairmentRecruitingNCT06782464Not applicable1 country
- Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)RecruitingNCT053546221 country
- Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic PatientsRecruitingNCT07018336Not applicable1 country
- Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After StrokeRecruitingNCT06726434Not applicable1 country