Myofascial Pain Syndromes clinical trials
The registry lists 339 studies for Myofascial Pain Syndromes across more than 10 countries. 66 are recruiting or about to start. 250 of them are mainly about Myofascial Pain Syndromes (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Temporomandibular Joint Dysfunction Syndrome too: 392 studies, 80 open.
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Status
Who runs them
Cairo University (17) · Riphah International University (16) · University of Alcala (7) · Universitat Internacional de Catalunya (6) · University of Sao Paulo (5) · Ankara University (5) · Universidad Complutense de Madrid (4) · Istanbul University (4)
What is being tested here
Drugs under test in Myofascial Pain Syndromes studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lidocaine | 3 | 0 | 9 |
| Botulinum toxin type A | 2 | 2 | 7 |
| Sodium Bicarbonate | 1 | 0 | 1 |
| Platelet rich plasma | 1 | 0 | 1 |
| Betamethasone | 1 | 0 | 1 |
| Botulinum Toxins | 1 | 0 | 1 |
| Steroids | 1 | 0 | 1 |
| Cyclobenzaprine | 0 | 2 | 2 |
| Capsaicin | 0 | 0 | 2 |
| Glucose | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Comparing Instrument-Assisted Soft Tissue Mobilization and Muscle Energy Technique for Myofascial Pain Syndrome in Women · University of Lahore
- Dec 2026Effectiveness of Tele-Rehabilitation in Managing Rhomboid Trigger Points in Patients With Myofascial Pain Syndrome · Riphah International University
- Dec 2026PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain · University of Kyrenia
- Dec 2026Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial Pain · Flávio Magno Gonçalves
- Dec 2026Reflex Therapy of Temporomandibular Dysfunctions · Palacky University
- Dec 2026Investigating the Minimum Number of Needling Required to Optimize Trigger Point Injections Outcome · University of Arizona
- Dec 2026High-Intensity Laser Therapy for Trapezius Myofascial Pain (HILT-TRAP Study) · Neveen Abd El Maksoad Kohaf
- Dec 2026Comparison of Ischemic Release and Sustained Pressure Direct Myofascial Release in Upper Trapezius Trigger Point · Foundation University Islamabad
- Dec 2026Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia · Riyadh Elm University
- Jan 2027Comparison of 26G and 30G Needles for Masseter Trigger Point Injections in Patients With Myofascial Pain Syndrome · Medipol University
Who these studies take
Of the 34 Myofascial Pain Syndromes studies recruiting now, 5 (15%) set no upper age limit and 26 (76%) stop at 75 or younger. 2 (6%) take children under 18. 5 (15%) are for women only and 1 (3%) for men only; 4 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 28 (82%) | 24 (71%) |
| 30 | 32 (94%) | 28 (82%) |
| 40 | 27 (79%) | 26 (76%) |
| 50 | 23 (68%) | 23 (68%) |
| 65 | 16 (47%) | 16 (47%) |
| 75 | 8 (24%) | 8 (24%) |
| 85 | 6 (18%) | 6 (18%) |
Across all 339 studies, recruiting or not: 78% stop at 75 or younger and 73% at 65; 4% take children; 9% are for women only and 2% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Myofascial Pain Syndromes studies take
Of 204 interventional studies with no phase under Myofascial Pain Syndromes, half reached primary completion within 5 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 5 mo2–13 · 204 studies | — | 5 mo2–12 · 202 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
Newly registered5
- Comparison of 26G and 30G Needles for Masseter Trigger Point Injections in Patients With Myofascial Pain SyndromeNov 9, 2026NCT07926113
- Effects of IASTM, Deep Friction Massage, and Sham Instrument-Assisted Soft Tissue Mobilization on Electromyographical Activation, Pain and Function in Non-Specific Low Back PainNov 6, 2026NCT07921784
- Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial PainOct 29, 2026NCT07904364
- Comparing Instrument-Assisted Soft Tissue Mobilization and Muscle Energy Technique for Myofascial Pain Syndrome in WomenOct 29, 2026NCT07904559
- Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck PainOct 15, 2026NCT07876739
Studies
Recruiting first, then most recently updated. Showing 50 of 339. Browse all 339 → or search them.
- Comparison of 26G and 30G Needles for Masseter Trigger Point Injections in Patients With Myofascial Pain SyndromeNot yet recruitingNCT07926113Not applicable1 country
- Effects of IASTM, Deep Friction Massage, and Sham Instrument-Assisted Soft Tissue Mobilization on Electromyographical Activation, Pain and Function in Non-Specific Low Back PainNot yet recruitingNCT07921784Not applicable
- Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial PainNot yet recruitingNCT079043641 country
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeRecruitingNCT07572994Not applicable1 country
- Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck PainNot yet recruitingNCT07876739Not applicable1 country
- MRI Study of OnabotulinumtoxinA (OnabotA) Effect on Jaw Muscle PainNot yet recruitingNCT07878780Phase 21 country
- The Immediate Effects of Dry Needling Acupuncture on Pain Intensity and Pressure Pain Threshold in Patients With Myofascial Pain Syndrome of the Upper TrapeziusNot yet recruitingNCT07833475Not applicable1 country
- Botulinum Toxin Type A Versus Triamcinolone for Facial MyalgiaNot yet recruitingNCT07867379Phase 41 country
- Comparison of Ischemic Release and Sustained Pressure Direct Myofascial Release in Upper Trapezius Trigger PointRecruitingNCT07838584Not applicable1 country
- Kinesio Taping for Upper Trapezius Myofascial Trigger PointsNot yet recruitingNCT07790042Not applicable1 country
- Ischemic Compression and Low-Level Laser Therapy for Myofascial Low Back PainNot yet recruitingNCT07832422Not applicable1 country
- Focused Shockwave Therapy for Neck and Shoulder Myofascial PainRecruitingNCT07660523Not applicable1 country
- The Effectiveness of Dry Needling Treatment in Patients Diagnosed With Dorsal Myofascial Pain Syndrome.RecruitingNCT06338514Not applicable1 country
- Emmett Technique Versus Bowen Technique for Upper Trapezius Myofascial Pain SyndromeEnrolling by invitationNCT07767747Not applicable1 country
- Does Addition of Medial Pterygoid Muscle Injection Improve the Outcome of Botulinum Toxin Therapy for Masticatory Myofascial Pain Syndrome?Not yet recruitingNCT07774884Not applicable1 country
- Reflex Therapy of Temporomandibular DysfunctionsRecruitingNCT07321483Not applicable1 country
- Effectiveness of Mitragynine Topical Patch for Pain Reduction in Myofascial Pain SyndromeNot yet recruitingNCT07713771Phase 31 country
- Effectiveness of Tele-Rehabilitation in Managing Rhomboid Trigger Points in Patients With Myofascial Pain SyndromeRecruitingNCT07573527Not applicable1 country
- Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial PainRecruitingNCT07278570Not applicable1 country
- Treatment of Pectoralis Trigger Points in Patients With Pseudo AnginaNot yet recruitingNCT07728357Not applicable1 country
- Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial PainNot yet recruitingNCT07706153Not applicable1 country
- Effects of Different Myofascial Release Techniques on Function in Chronic Non-Specific Neck PainRecruitingNCT07694882Not applicable1 country
- Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain SyndromeRecruitingNCT07494162Not applicable1 country
- PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial PainRecruitingNCT07547605Phase 41 country
- COMPARISON OF THREE TREATMENT MODALITIES IN MYOFASCIAL PAIN SYNDROMERecruitingNCT07511751Not applicable1 country
- Low-Energy Ultrasound, Electrical and Magnetic Field Stimulation in Therapy-Resistant Myofascial Pain SyndromeRecruitingNCT05851326Not applicable2 countries
- Effectiveness of PRP Pharmacopuncture for Chronic Neck Pain in Cervical Myofascial Syndrome of the Upper TrapeziusRecruitingNCT07119255Not applicable1 country
- Immediate Effect of Dry Needling on Calf Muscles Pain Pressure Threshold,Sprint Speed and Functional Performance in Amateur Football PlayerRecruitingNCT07525921Not applicable1 country
- Comparison of the Effectiveness of Dry Needling Versus the Combination of Dry Needling and Local Anesthetic Injection in Myofascial Pain Syndrome of the Upper Trapezius Muscle: A Sham-Controlled, Randomized Clinical TrialNot yet recruitingNCT07456735Phase 41 country
- The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial PainRecruitingNCT07270276Not applicable1 country
- High-Intensity Laser Therapy for Trapezius Myofascial Pain (HILT-TRAP Study)Not yet recruitingNCT07352787Not applicable1 country
- Artificial Intelligence Clinical DecisionNot yet recruitingNCT07342790Not applicable1 country
- Investigating the Minimum Number of Needling Required to Optimize Trigger Point Injections OutcomeEnrolling by invitationNCT04732507Phase 21 country
- Effectiveness of Percutaneous Electrolysis and Dry Needling vs. Standard Therapy for Whiplash SyndromeNot yet recruitingNCT06938425Not applicable
- Diffusion MRI for Quantitative Assessment of Myofascial PainRecruitingNCT068920411 country
- Effect of MET vs Neck Calliet Exercises on Neck Pain and Disability in NursesRecruitingNCT07138807Not applicable1 country
- Post-Isometric Relaxation in Temporomandibular DisordersNot yet recruitingNCT07130279Not applicable
- High Intensity Laser Therapy (HILT) on Myofascial Trigger Points.RecruitingNCT04445545Not applicable1 country
- Comparing Physical Therapy Interventions on Craniovertebral Angle (CVA) in Cervical Myofascial Pain Syndrome (MPS)RecruitingNCT07098754Not applicable1 country
- EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck MusclesRecruitingNCT07082972Phase 41 country
- Efficacy of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients With Neck PainRecruitingNCT07058636Not applicable1 country
- Manual Therapy Techniques for Cervical Pain: Algometric EvaluationEnrolling by invitationNCT06982456Not applicable1 country
- Clinical Study on Dry Needling for Primary Dysmenorrhea and Its Preliminary Correlation With AcupointsRecruitingNCT06316583Not applicable1 country
- Magnesium Sulfate and Trigger PointsNot yet recruitingNCT06975813Phase 2
- Effect of Shock Wave Therapy on Myofascial Pain Syndrome in Adolescent AthletesNot yet recruitingNCT06845475Not applicable1 country
- Effects of Home-based Surface Electrical Stimulation for Patients with Cervical Myofascial Pain SyndromeRecruitingNCT05972837Not applicable1 country
- Myofascial Release Technique in Women With Primary DysmenorrheaRecruitingNCT06492148Not applicable1 country
- Safe Zone in Trigger Point InjectionRecruitingNCT066643591 country
- Subthreshold Stimulation Versus Suprathreshold Stimulation in People With Chronic Low Neck PainNot yet recruitingNCT06559358Not applicable
- Trigger Point Injection in Patients With Myofascial Pain SyndromeRecruitingNCT06555523Not applicable1 country