Bruxism clinical trials
The registry lists 151 studies for Bruxism across more than 10 countries. 39 are recruiting or about to start. 91 of them are mainly about Bruxism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Sleep Bruxism too: 190 studies, 47 open.
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Status
Who runs them
Cairo University (6) · Postgraduate Institute of Dental Sciences Rohtak (5) · Istanbul University (4) · Gazi University (4) · Hasan Kalyoncu University (3) · Bandırma Onyedi Eylül University (3) · Medotech A/S (2) · Ain Shams University (2)
What is being tested here
Drugs under test in Bruxism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Psychological Resilience, Perceived Stress and Periodontal Status Among Bruxers · Postgraduate Institute of Dental Sciences Rohtak
- Dec 2026Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis · Bilecik Seyh Edebali Universitesi
- Dec 2026Bruxism and Diadinamic Current · Inonu University
- Dec 2026Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism · Necmettin Erbakan University
- Apr 2027Bruxism, Anxiety, and Periodontal Status Among Dental Students · Al-Hawash Private University
- Apr 2027Movement of Dental Implants During Osseointegration · Aula Dental Avanzada
- May 2027The General Aim is to Implement Clinical Assessment of Overload by Voluntary Bite Force Registration to Enable Future Simple But Precise Risk Assessment to Provide Individualized Treatment Plans. · Malmö University
Who these studies take
Of the 15 Bruxism studies recruiting now, 8 (53%) set no upper age limit and 7 (47%) stop at 75 or younger. 2 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 8 (53%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (7%) | 1 (7%) |
| 18 | 11 (73%) | 11 (73%) |
| 30 | 14 (93%) | 14 (93%) |
| 40 | 14 (93%) | 14 (93%) |
| 50 | 13 (87%) | 13 (87%) |
| 65 | 9 (60%) | 9 (60%) |
| 75 | 8 (53%) | 8 (53%) |
| 85 | 8 (53%) | 8 (53%) |
Across all 151 studies, recruiting or not: 74% stop at 75 or younger and 73% at 65; 15% take children; 5% are for women only and 1% for men only; 49% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Bruxism studies take
Of 60 interventional studies with no phase under Bruxism, half reached primary completion within 7 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 7 mo3–13 · 60 studies | — | 8 mo3–13 · 59 studies |
| Observational | 15 mo7–28 · 13 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Movement of Dental Implants During OsseointegrationOct 27, 2026NCT07297147
Newly registered2
- Prospective Evaluation of the Relationship Between Pes Planus and BruxismNov 9, 2026NCT07923890
- Trabecular Bone Changes After Periodontal Treatment in Patients With and Without BruxismOct 29, 2026NCT07904455
Studies
Recruiting first, then most recently updated. Showing 50 of 151. Browse all 151 → or search them.
- Bruxism, Anxiety, and Periodontal Status Among Dental StudentsRecruitingNCT075794161 country
- Movement of Dental Implants During OsseointegrationRecruitingNCT072971471 country
- The General Aim is to Implement Clinical Assessment of Overload by Voluntary Bite Force Registration to Enable Future Simple But Precise Risk Assessment to Provide Individualized Treatment Plans.Enrolling by invitationNCT072667011 country
- Influence Of Different Relaxation Techniques On Stress Level For Patients With Bruxism Using Salivary Biomarkers.Not yet recruitingNCT07868341Not applicable1 country
- Botulinum Toxin-A for Bruxism Using Digital Occlusal AnalysisNot yet recruitingNCT07640035Early Phase 11 country
- Bruxism Therapy of Facial PainRecruitingNCT07611643Not applicable1 country
- Impact of Distress Level, Sleep Quality and Occlusal Trauma on Periodontal Status Among BruxersNot yet recruitingNCT07615153
- Psychological Resilience, Perceived Stress and Periodontal Status Among BruxersNot yet recruitingNCT076151401 country
- Comparison of the Effects of Different Massage Techniques in Individuals With BruxismNot yet recruitingNCT07567183Not applicable
- Neuromuscular Function and Performance in Athletes With or Without BruxismEnrolling by invitationNCT075562111 country
- Effect of Night Guard Use on Masseter Muscle Thickness in Children With BruxismRecruitingNCT07548502Not applicable1 country
- Bruxism, Pelvic Pain, Erectile Dysfunction, and Anxiety in Young Adult MenEnrolling by invitationNCT074693451 country
- Bruxism and Pelvic Floor Dysfunction in Young WomenEnrolling by invitationNCT074379241 country
- Association Between Child and Parental Stress and Bruxism in Children Aged 8-11 YearsNot yet recruitingNCT074335951 country
- Somatosensory Training Versus Exercise Therapy in Awake BruxismRecruitingNCT07336082Not applicable1 country
- Effects of a Biopsychosocial Approach Added to Physiotherapy in Temporomandibular DisordersNot yet recruitingNCT07320144Not applicable
- Bruxism and Diadinamic CurrentRecruitingNCT07241728Not applicable1 country
- Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism PainRecruitingNCT07109882Phase 41 country
- ePROPP - eHealth for Preventing and Reducing Orofacial Pain in the PopulationNot yet recruitingNCT07095101Not applicable
- EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck MusclesRecruitingNCT07082972Phase 41 country
- Comparison of the Effects of Classical Massage and Conventional Treatment Methods in Phone Addicted Bruxist PatientsEnrolling by invitationNCT07028151Not applicable1 country
- Behavioral Interventions for Controlling Oral BehaviorsRecruitingNCT07022795Not applicable1 country
- A Comparative Study of EMG Biofeedback and Pharmacotherapy for the Treatment of Masticatory Muscle Hyperactivity in Bruxism PatientsNot yet recruitingNCT06894472Not applicable1 country
- Prevalence of Temporomandibular Joint Disorders in Wind MusiciansNot yet recruitingNCT06823531
- Effectiveness of Visceral Manual Therapy in Bruxist PatientsRecruitingNCT05751694Not applicable1 country
- Analysis of Occlusal Force Distribution in Digital and Conventional Occlusal SplintNot yet recruitingNCT06652217Not applicable
- "Salivary Melatonin and Cortisol Levels in Individuals with Bruxism"Not yet recruitingNCT06623643
- Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With PeriodontitisRecruitingNCT06435208Not applicable1 country
- mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in BruxismNot yet recruitingNCT06457646
- Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis.RecruitingNCT05995431Not applicable1 country
- Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation in BruxismNot yet recruitingNCT06386809Not applicable1 country
- Fabrication and Insertion of Michigan Splints by Dental StudentsEnrolling by invitationNCT063774751 country
- Assessment of Risk Factors in Patients With Non-carious Cervical LesionsNot yet recruitingNCT063640201 country
- Endocrine Disruptors in Saliva Released From Bruxism Splints.Not yet recruitingNCT06088238
- Evaluation of BTX Injections in Treatment of BruxismNot yet recruitingNCT05980559Phase 3
- Botulinum Toxin Administration on Masticatory PerformanceRecruitingNCT055625311 country
- Comparative Evaluation of Gnathological Function With Bruxoff®Not yet recruitingNCT06096753
- Mandibular Muscle Energy Technique in Patients With Mandibular Joint Pathology and BruxismRecruitingNCT05594511Not applicable1 country
- The Effect on Envelope of Motion in Asymptomatic BruxersRecruitingNCT05604729Not applicable1 country
- Prospective Evaluation of the Relationship Between Pes Planus and BruxismCompletedNCT079238901 country
- Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial PainCompletedNCT07090551Not applicable1 country
- Trabecular Bone Changes After Periodontal Treatment in Patients With and Without BruxismCompletedNCT079044551 country
- Low-Level Laser Therapy Versus Occlusal Splint Therapy for Bruxism in ChildrenCompletedNCT07865845Not applicable1 country
- Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD PainCompletedNCT07584642Not applicable1 country
- Synchronous vs Asynchronous Telerehabilitation for BruxismCompletedNCT07827495Not applicable1 country
- Biochemical Factors in Patients With and Without BruxismCompletedNCT077836851 country
- Short-Term Symptom Changes in Adults With Teeth Clenching or Grinding and Jaw Symptoms Receiving Splint, Botulinum Toxin, or Medication Plus Splint CareCompletedNCT075860721 country
- Botulinum Toxin Type A Versus Oral Ibuprofen for BruxismCompletedNCT07732751Phase 41 country
- Effects of Different Graston Technique Application Speeds on Trapezius Muscle Stiffness, Pressure Pain Threshold, Pain, and Muscle Oxygenation in Patients With BruxismCompletedNCT07506733Not applicable1 country
- The Effect of Bruxism on BalanceCompletedNCT073081451 country