Adrenergic alpha-Agonists clinical trials
A class of medicines: the studies that test any of its 8 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Get an email when these change. Save the adrenergic alpha-agonists studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Medicines in this class
Studies that test each. A study of two counts under both, and once above.
- Naphazoline
- 2
- Racepinephrine
- 2
- Etilefrine
- 1
- Synephrine
- 1
Studies by the year they started
446 studies that test it; most in 2024 (35); 3 more planned to start later
| Year | Studies |
|---|---|
| 1999 | 1 |
| 2000 | 1 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 2 |
| 2005 | 4 |
| 2006 | 5 |
| 2007 | 6 |
| 2008 | 11 |
| 2009 | 2 |
| 2010 | 14 |
| 2011 | 11 |
| 2012 | 17 |
| 2013 | 13 |
| 2014 | 30 |
| 2015 | 20 |
| 2016 | 26 |
| 2017 | 28 |
| 2018 | 24 |
| 2019 | 27 |
| 2020 | 19 |
| 2021 | 20 |
| 2022 | 30 |
| 2023 | 32 |
| 2024 | 35 |
| 2025 | 32 |
| 2026 | 30 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 39 · Other 412
General Hospital of Ningxia Medical University (22) · Cairo University (15) · Kasr El Aini Hospital (8) · Assiut University (8) · Seoul National University Hospital (7) · Sahlgrenska University Hospital (6) · Allergan (6) · Mayo Clinic (6)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing one of them · 451
- REctus Sheath TrialRecruitingPhase 2Duke UniversityNCT07068243Written as 1.0% lidocaine with epinephrine (1:100,000)
- Vasopressor Agents in Pulmonary Hypertension CrisisRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07667829Written as Norepinephrine
- Split Face Study of the Duration of Local Anesthetics - Fifth ArmNot yet recruitingPhase 4Weill Medical College of Cornell UniversityNCT07724418Written as Lidocaine HCl/Epinephrine
- OB VEGA-Phenylephrine vs Norepinephrine OutcomesNot yet recruitingPhase 4Wake Forest University Health SciencesNCT07900919Written as Norepinephrine
- ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal AgeNot yet recruitingNot applicableGeneral Hospital of Ningxia Medical UniversityNCT07894783Written as Norepinephrine
- Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary SurgeryNot yet recruitingNot applicableAssiut UniversityNCT07892586Written as Low-Dose Norepinephrine
- ESP Blocks in Breast Free FlapsRecruitingPhase 1Carilion ClinicNCT07891039Written as Bupivacaine with Epinephrine and Dexamethasone
- Phenotype Guided Vasoactive Medication During Kidney TransplantationEnrolling by invitationPhase 4Jennifer CutlerNCT07633600Written as Phenotype-Guided Vasoactive Management
- Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean DeliveryRecruitingPhase 4Cairo UniversityNCT07379710Written as Ephedrine and Norepinephrine infusion
- Pre-induction Norepinephrine in Septic Patients Undergoing SurgeryNot yet recruitingNot applicableAssiut UniversityNCT07869693Written as Norepinephrine
- Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic ShockRecruitingNot applicableChonnam National University HospitalNCT07562932Written as Norepinephrine
- Comparison of Milrinone and Epinephrine on TAPSERecruitingNot applicableMansoura UniversityNCT07144267Written as Epinephrine
- Epinephrine Dose: Optimal Versus Standard Evaluation TrialRecruitingPhase 4Unity Health TorontoNCT03826524Written as Epinephrine
- An Outpatient Study of the Efficacy of ARS-2 in Patients With Chronic Spontaneous UrticariaRecruitingPhase 2ARS Pharmaceuticals, Inc.NCT06927999Written as 0.5 mg epinephrine
- Superiority of Phenylephrine Versus Norepinephrine in Complex Spine Surgery (SPiNeS)Not yet recruitingPhase 4Mayo ClinicNCT07796282Written as Norepinephrine bitartrate infusion
- Intralesional Chemotherapy (IC): Cisplatin + EpinephrineRecruitingPhase 2University of MiamiNCT07392580Written as Epinephrine injection
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee ArthroplastyNot yet recruitingPhase 4Wake Forest University Health SciencesNCT07097493Written as Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination
- Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)RecruitingPhase 4University of California, DavisNCT07322133Written as Norepinephrine
- Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral ChallengesRecruitingPhase 1Dr. George LuciukNCT07038746Written as Inhaled Epinephrine
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal SurgeryRecruitingNot applicableCairo UniversityNCT07719075Written as Norepinephrine 10 mcg
See all 451 studies that test one of the adrenergic alpha-agonists →
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting5
- REctus Sheath TrialNov 6, 2026NCT07068243
- Vasopressor Agents in Pulmonary Hypertension CrisisOct 30, 2026NCT07667829
- Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean DeliveryOct 21, 2026NCT07379710
- Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic ShockOct 15, 2026NCT07562932
- Comparison of Milrinone and Epinephrine on TAPSEOct 13, 2026NCT07144267
Stopped2
- Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast ReconstructionTerminatedOct 28, 2026NCT06080178
- Blood PREssure Augmentation in Large-vessel Occlusion Stroke StudyTerminatedOct 14, 2026NCT04218773
Newly registered6
- Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic SurgeryOct 30, 2026NCT07907666
- OB VEGA-Phenylephrine vs Norepinephrine OutcomesOct 28, 2026NCT07900919
- Comparison of Lidocaine With and Without Adrenaline for Reducing EcchymosisOct 27, 2026NCT07897201
- ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal AgeOct 26, 2026NCT07894783
- ESP Blocks in Breast Free FlapsOct 23, 2026NCT07891039
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- Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary SurgeryOct 23, 2026NCT07892586