Nasal Obstruction clinical trials
The registry lists 173 studies for Nasal Obstruction across more than 10 countries. 31 are recruiting or about to start. 113 of them are mainly about Nasal Obstruction (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Who runs them
Aerin Medical (10) · GlaxoSmithKline (6) · Stanford University (5) · Third Wave Therapeutics (4) · Church & Dwight Company, Inc. (3) · Bayer (3) · University Hospital Ostrava (3) · Spirox, Inc. (3)
What is being tested here
Drugs under test in Nasal Obstruction studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Oxymetazoline | 1 | 0 | 6 |
| Xylometazoline | 1 | 0 | 2 |
| Dipyrone | 1 | 1 | 1 |
| Acetaminophen | 0 | 1 | 3 |
| Phenylephrine | 0 | 2 | 3 |
| Bilastine | 0 | 2 | 3 |
| Triamcinolone | 0 | 0 | 2 |
| Pseudoephedrine | 0 | 1 | 2 |
| Favipiravir | 0 | 2 | 2 |
| Peramivir | 0 | 2 | 2 |
Drug classes tested here Antihistamines 9 · Corticosteroids 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Antibiotic Prophylaxis in Rhinoplasty · Phase 3 · Stanford University
- Jun 2027Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults · Phase 3 · Brainfarma Industria Química e Farmacêutica S/A
- Nov 2026Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction · Laboratoires Gilbert
- Dec 2026Nasal Obstruction With Oxymetazoline and Corticosteroids · Washington University School of Medicine
- Dec 2026Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO" · Laboratoires Gilbert
- Mar 2027Open-Label Study to Evaluate the Safety and Effectiveness of the Spirair Implant · Spirair, Inc
- Mar 2027Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension Grafts · Cumhuriyet University Hospital
- Mar 2027Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion · University of Alberta
- Mar 2027Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate Reduction in China · Smith & Nephew, Inc.
- Apr 2027Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis · Chien Yu Huang
Who these studies take
Of the 20 Nasal Obstruction studies recruiting now, 7 (35%) set no upper age limit and 11 (55%) stop at 75 or younger. 4 (20%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (10%) | 2 (10%) |
| 18 | 18 (90%) | 18 (90%) |
| 30 | 18 (90%) | 18 (90%) |
| 40 | 17 (85%) | 17 (85%) |
| 50 | 16 (80%) | 16 (80%) |
| 65 | 14 (70%) | 14 (70%) |
| 75 | 9 (45%) | 9 (45%) |
| 85 | 8 (40%) | 8 (40%) |
Across all 173 studies, recruiting or not: 48% stop at 75 or younger and 36% at 65; 25% take children; 1% are for women only and 1% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Nasal Obstruction studies take
Of 60 interventional studies with no phase under Nasal Obstruction, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo9–36 · 60 studies | — | 27 mo10–43 · 39 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Newly registered2
- Influence of Patient Positioning During Nasal LavageNov 6, 2026NCT07921680
- Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal ObstructionOct 13, 2026NCT07870252
Studies
Recruiting first, then most recently updated. Showing 50 of 173. Browse all 173 → or search them.
- Influence of Patient Positioning During Nasal LavageNot yet recruitingNCT07921680Not applicable1 country
- Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal ObstructionRecruitingNCT07870252Not applicable1 country
- Measuring Nasal Airway Changes After VivAer Treatment Using AI AnalysisRecruitingNCT07574918Not applicable1 country
- Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate Reduction in ChinaRecruitingNCT07025304Not applicable1 country
- Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and ToddlersNot yet recruitingNCT072572241 country
- Comparison Between Turbinoplasty Techniques in Chronic Nasal Obstruction Microdebrider Coblation andSubmucosalBipolarDiathermyTechniquesduetohypertrophoidturbinateNot yet recruitingNCT07832916Not applicable
- Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO"RecruitingNCT05494346Not applicable1 country
- Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal ObstructionRecruitingNCT065802101 country
- Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in HypotoniaRecruitingNCT05527652Not applicable1 country
- Active vs. Passive VR During Office-based ENT ProceduresNot yet recruitingNCT07599826Not applicable1 country
- Evaluation of the Outcome of Septoplasty With or Without Inferior Turbinate ReductionNot yet recruitingNCT07731152Not applicable
- Evaluation of the Reliability of AAR as an Independent Tool for Surgical Indication in Nasal ObstructionRecruitingNCT073797751 country
- Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension GraftsRecruitingNCT075318101 country
- Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in AdultsRecruitingNCT07626437Phase 31 country
- Observational Study of RHINOSEDAL in Acute Nasal ObstructionNot yet recruitingNCT076205221 country
- Nasal Obstruction and Olfactory LossesRecruitingNCT05920330Not applicable1 country
- Antibiotic Prophylaxis in RhinoplastyEnrolling by invitationNCT04194216Phase 31 country
- Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary ExpansionRecruitingNCT04190953Not applicable1 country
- Long-term Evaluation of Nasopharyngeal Airway in HypotoniaEnrolling by invitationNCT06614582Not applicable1 country
- Acoustic Resonance Therapy for Treating Empty Nose SyndromeNot yet recruitingNCT07215013Not applicable1 country
- Nasal Obstruction With Oxymetazoline and CorticosteroidsRecruitingNCT06830109Phase 21 country
- Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal CongestionNot yet recruitingNCT07114107Not applicable1 country
- Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and PalateRecruitingNCT070484181 country
- Study to Investigate the Efficacy and Safety of Apomivir®Not yet recruitingNCT01677689Phase 21 country
- Diagnosis of Respiratory Disorders by the Numerical Modeling.RecruitingNCT066702611 country
- Outcome Analysis in SeptorhinoplastyRecruitingNCT039253891 country
- VivAer: A Correlation Between Symptom Scores and Objective FindingsRecruitingNCT05573919Not applicable1 country
- Subjective and Objective Outcome of Septoplasty With or Without InfundibulotomyRecruitingNCT05698940Not applicable1 country
- Nasal Obstruction Compared by Rhinomanometry and Nasal Inspiratory Peak Flow After Endoscopic Nasal SurgeryRecruitingNCT05921396Not applicable1 country
- Impact of Nasal Isotonic Solution Irigation on Healthy Athletes' Nasal Flow and Nasal Obstruction Exercise OutcomesRecruitingNCT05948800Not applicable1 country
- Nasal Breathing and Physical CapacityRecruitingNCT04712799Phase 41 country
- Study of the AERin Medical Vivaer® ARC Stylus for Nasal AirWAY ObstructionCompletedNCT04277507Not applicable1 country
- A Prospective Study Comparing VivAer to Alternative Surgical Procedures to Treat Nasal Airway Obstruction in Patients With Nasal Valve Dysfunction.Active, not recruitingNCT069229551 country
- Vivaer® Procedure for Treatment of Nasal Airway Obstruction StudyCompletedNCT04549545Not applicable1 country
- The Vivaer Procedure for Treatment of the Septal Swell Bodies (SWELL)CompletedNCT05099263Not applicable1 country
- An Ambispective Registry Study Comparing Clinical Outcomes of Surgical Interventions for the Treatment of Nasal Airway Obstruction.CompletedNCT069920371 country
- Virtual Surgery of the Upper AirwaysCompletedNCT048292011 country
- Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?CompletedNCT05287841Not applicable1 country
- Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic NasopharyngitisCompletedNCT07568548Not applicable1 country
- Radiofrequency Ablation Versus Lateralization as Office-Based Procedures for Bilateral Inferior Turbinate HypertrophyCompletedNCT07772505Not applicable1 country
- A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy AdultsCompletedNCT07582328Phase 21 country
- Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic RhinitisCompletedNCT07593898Phase 41 country
- Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic RhinitisActive, not recruitingNCT07323888Not applicable1 country
- Open-Label Study to Evaluate the Safety and Effectiveness of the Spirair ImplantActive, not recruitingNCT06163404Not applicable1 country
- Steroid Treatment for Elimination of Rebound Obstruction From Intranasal DecongestantsTerminatedNCT07168148Phase 21 country
- Compensatory Inferior Turbinate Surgery in SeptorhinoplastyCompletedNCT07481045Not applicable1 country
- Efficacy And Safety of An IRE System For Treatment of Inferior Turbinate HypertrophyCompletedNCT06438185Not applicable4 countries
- Acupuncture for Nasal Congestion in Allergic RhinitisCompletedNCT05709977Not applicable1 country
- Effects of SinuSonic on Psychological and Physical Well-BeingTerminatedNCT06268730Not applicable1 country
- Laser Posterior Nasal Nerve NeurolysisActive, not recruitingNCT07050992Not applicable1 country