A Phase 4 interventional study of Phenylephrine and Norepinephrine in Hypotension During Surgery and Cesarean Birth, sponsored by Wake Forest University Health Sciences. Not yet recruiting at 1 site in United States. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by Wake Forest University Health Sciences · Phase 4, Interventional, and Treatment
OB VEGA-Phenylephrine vs Norepinephrine Outcomes evaluation
This study aims to evaluate the comparison of phenylephrine to norepinephrine for the treatment of anesthesia induced hypotension during cesarean delivery
885 studies on the registry are indexed under Hypotension; 195 are open to participants now.
This study's planned enrollment of 1,500 is above the median of 87 across 590 interventional studies indexed under Hypotension.
Browse Hypotension studies →Wake Forest University Health Sciences is the lead sponsor of 1,351 studies on the registry; 201 are open to participants now.
Of its 332 completed or terminated interventional studies of FDA-regulated products, 251 (76%) have results posted.
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Exclusion Criteria
Phenylephrine is a selective alpha-1 adrenergic receptor agonist and sympathomimetic medication - treatment of hypotension during cesarean delivery with the use of either phenylephrine or norepinephrine
Drug: Phenylephrine
Norepinephrine (also called noradrenaline) is an organic chemical in the catecholamine family that functions in the human body and brain as both a neurotransmitter and a hormone - treatment of hypotension during cesarean delivery with the use of either phenylephrine or norepinephrine
Drug: Norepinephrine
use of phenylephrine for hypotension intraoperatively during cesarean delivery
Also known as: Phenylephrine is a selective alpha-1 adrenergic receptor agonist and sympathomimetic medication
use of norepinephrine for hypotension intraoperatively during cesarean delivery
Also known as: noradrenaline
Change in Uterine tone-obstetrician evaluation scores
measured by 0-10 numeric rating scale (0 = atonic, 10 = firm/optimal), assessed by obstetrician blinded to group, at fixed timepoints (2, 5, 10 minutes after delivery) - higher scores denoting more desirable
Time frame: up to 2 hours
Change in Uterine tone-obstetrician evaluation scores with Uterine tone-uterotonic drug administration
measured by 0-10 numeric rating scale (0 = atonic, 10 = firm/optimal), assessed by obstetrician blinded to group, at fixed timepoints (2, 5, 10 minutes after delivery) - higher scores denoting more desirable - measured by addition of supplemental uterotonics - methylergonivine, carboprost, misoprostol, total amount of oxytocin over 20 minutes post delivery
Time frame: up to 2 hours
Uterine tone-blood loss amount
Quantitative blood loss (QBL) via gravimetric sponge/lap weighing plus calibrated suction canister volume, corrected for irrigation fluid
Time frame: hour 24
Uterine tone-blood loss amount - Postoperative hemoglobin drop
Quantitative blood loss (QBL) Postoperative hemoglobin drop (pre-op minus postoperative day 1 hemoglobin)
Time frame: hour 24
Incidence of Hypotension
systolic blood pressure \<80% baseline
Time frame: up to 2 hours
Incidence of Bradycardia
heart rate \<60bpm
Time frame: up to 2 hours
Number of rescue boluses of vasopressor
number of rescue bolus doses of vasopressors used
Time frame: up to 2 hours
Nausea
presence or absence of nausea occurring
Time frame: up to 2 hours
Intraoperative nausea/vomiting (yes/no)
presence or absence of vomiting occurring
Time frame: up to 2 hours
umbilical blood gas
if done, measurement of pH, base excess, and lactate
Time frame: up to 2 hours
Fetal Apgar scores
measurement of Apgar scores at minutes 1 and 5 after birth * 7 to 10: Normal and healthy; the baby is doing well. * 4 to 6: Fairly low; the baby might need some help breathing or warming up. * 3 or lower: Critically low; the baby needs immediate medical care or life-saving help
Time frame: Minute 1 and 5
Incidence of Postpartum hemorrhage
incidence of postpartum hemorrhage and if transfusion or other blood product derivative required
Time frame: Hour 24
Incidence of Maternal Shivering
incidence of shivering occurring -yes or no
Time frame: up to 2 hours
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Phenylephrine · Norepinephrine
Wake Forest University Health Sciences →