An interventional study of Norepinephrine in Sepsis and Hypotension, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-09.
Sponsored by Assiut University · Not applicable, Interventional, and Prevention
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
Induction of general anesthesia in septic patients can cause severe hypotension due to vasodilation and reduced preload. Pre-emptive norepinephrine infusion may prevent post-induction hemodynamic collapse.
This prospective double-blind randomized trial will compare continuous prophylactic norepinephrine infusion started 30 minutes before induction versus standard care with rescue vasopressors only in adult septic patients undergoing surgery.
1,903 studies on the registry are indexed under Sepsis; 466 are open to participants now.
This study's planned enrollment of 90 is below the median of 105 across 899 interventional studies indexed under Sepsis.
Browse Sepsis studies →Assiut University is the lead sponsor of 4,919 studies on the registry; 2,116 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Continuous intravenous norepinephrine infusion at 0.07 mcg/kg/min initiated 30 minutes before induction of general anesthesia and maintained intraoperatively.
Drug: Norepinephrine
No prophylactic norepinephrine before induction. Vasopressors administered only as rescue medication for hypotension.
Drug: Norepinephrine
Continuous intravenous infusion of norepinephrine.
Incidence of post-induction hypotension
Number of patients with mean arterial pressure drop greater than 20% from baseline or mean arterial pressure less than 65 mmHg within the first 30 minutes after induction of general anesthesia.
Time frame: Periprocedurally
Mean arterial pressure
Mean arterial pressure in mmHg.
Time frame: Periprocedurally
Total dose of rescue vasopressors
Mean total dose of rescue vasopressors administered intraoperatively in micrograms.
Time frame: Immediately after the intervention/procedure/surgery
Total volume of intravenous fluids
Mean total volume of intravenous fluids administered intraoperatively in milliliters.
Time frame: Immediately after the intervention/procedure/surgery
Length of ICU stay
Mean length of intensive care unit stay in days.
Time frame: At 28 days
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Assiut University