Acetylcysteine clinical trials
Also written NAC, Acetadote and Mucomyst.
Related medicines add 1 study
Counted the way a researcher would: Acetylcysteine with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Acetylcysteine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 14 Sept 1963 · MUCOMYST · NDA 013601 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
453 studies that test it; most in 2023 (27); 3 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 1 |
| 1998 | 2 |
| 2000 | 3 |
| 2002 | 4 |
| 2003 | 7 |
| 2004 | 7 |
| 2005 | 10 |
| 2006 | 16 |
| 2007 | 21 |
| 2008 | 14 |
| 2009 | 16 |
| 2010 | 19 |
| 2011 | 20 |
| 2012 | 15 |
| 2013 | 22 |
| 2014 | 18 |
| 2015 | 19 |
| 2016 | 23 |
| 2017 | 21 |
| 2018 | 23 |
| 2019 | 20 |
| 2020 | 18 |
| 2021 | 26 |
| 2022 | 23 |
| 2023 | 27 |
| 2024 | 22 |
| 2025 | 16 |
| 2026 | 20 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 17 · Other 442
Medical University of South Carolina (20) · Ain Shams University (16) · Peking University People's Hospital (9) · Yale University (9) · University of Minnesota (8) · Stanford University (8) · Tanta University (7) · Baylor College of Medicine (5)
Often tested with
Tested in the same studies.
Thioctic Acid (6) · Sodium Bicarbonate (6) · Vitamin E (5) · Simethicone (4) · Carnitine (4) · Ascorbic Acid (4) · Dexamethasone (4) · Glycine (3)
Related medicines
As reviewed, each with the page that says it.
- A prodrug of Cysteine source
- One of Antioxidants source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 31, 6 in phase 3
Studies that test Acetylcysteine, phase 3 first.
- Dec 2026Efficiency of a Composite Personalised Care on Functional Outcome in Early PsychosisPhase 3 · Centre Hospitalier St Anne
- Dec 2026N-Acetylcysteine as Therapy for Transplantation- Associated Thrombotic MicroangiopathyPhase 2/3 · The First Affiliated Hospital of Soochow University
- Apr 2027Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic SurgeryPhase 3 · Memorial Sloan Kettering Cancer Center
- Apr 2027BabySTrong II taVNS Feeding TrialPhase 2/3 · Medical University of South Carolina
- Apr 2027N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled TrialPhase 2/3 · Fakultas Kedokteran Universitas Indonesia
- Oct 2027Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and PneumoniaPhase 3 · Chinese University of Hong Kong
- Nov 2026Effects of NAC on Symptoms of CHR PatientsNot applicable · Centre for Addiction and Mental Health
- Nov 2026A Randomised Controlled Trial, of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion CarriersPhase 2 · Western Sydney Local Health District
- Nov 2026An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative NeoplasmsPhase 1/2 · University of California, Irvine
- Nov 2026Efficacy & Safety of Dry Powder Ivy Extract (Syrup Prospan) Versus NAC Among COPD PatientsNot applicable · National University of Malaysia
Studies
Open first, then newest update. How each study uses Acetylcysteine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 459
- Oral N-Acetylcysteine on Diabetic Macular EdemaRecruitingPhase 2Khadija Ahmed Mhrose GlalNCT07917338Written as NAC
- N-Acetylcysteine for Bipolar and Alcohol Use DisordersNot yet recruitingPhase 2Medical University of South CarolinaNCT07913542Written as N-acetyl cysteine
- N-Acetylcysteine in the Management of Spontaneous Bacterial PeritonitisRecruitingPhase 1/2Tanta UniversityNCT07803952Written as NAC
- FEAST and HOPE: Redox PSC Pilot StudyNot yet recruitingPhase 2Brigham and Women's HospitalNCT07898839Written as N-Acetyl Cysteine (NAC)
- Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and PneumoniaRecruitingPhase 3Chinese University of Hong KongNCT03900988Written as N-acetyl cysteine
- NAC for Hematopoietic Recovery in Low/Intermediate-Risk AML After CR: A Randomized Controlled StudyNot yet recruitingNot applicablePeking University People's HospitalNCT07869342Written as N-acetyl-L-cysteine (NAC)
- Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia PatientsNot yet recruitingPhase 3Peking University People's HospitalNCT07737262Written as N-acetylcysteine
- Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-AcetylcysteineRecruitingPhase 4Theis S. ItenovNCT07273071Written as N-Acetylcysteine (NAC) Treatment
- Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal DystrophyRecruitingPhase 2Massachusetts Eye and Ear InfirmaryNCT04440280Written as N-acetyl cysteine (NAC) 10% solution
- Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung DiseaseRecruitingPhase 2David PalmaNCT05986318Written as N-Acetyl cysteine
- Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver FailureRecruitingNot applicableKing Edward Medical UniversityNCT07765823Written as N Acetyl Cysteine
- Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange SyndromeNot yet recruitingPhase 2Johns Hopkins UniversityNCT04381897Written as N-acetyl cysteine
- Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant HistologyRecruitingPhase 2Leslie BallasNCT06417190Written as Trimodal therapy (TMT) within 45 days of neoadjuvant chemotherapy (NAC)
- NAC-REPAIR for Post-surgical PainNot yet recruitingPhase 2University of ArizonaNCT07227649Written as NAC
- Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBTRecruitingPhase 1/2University of California, IrvineNCT04520139Written as N-Acetyl-Cysteine
- An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard TherapyRecruitingPhase 2Fudan UniversityNCT07117630Written as N-Acetylcysteine (NAC) Treatment
- Effect of Acetylcysteine Inhalation on Incidence and Time to Develop Ventilator Associated Pneumonia in Critically Ill Mechanically Ventilated PatientsRecruitingPhase 4Cairo UniversityNCT07409727Written as Acetyl cysteine
- Imaging Acetadote Metabolism in GlioblastomaRecruitingEarly Phase 1University of Texas Southwestern Medical CenterNCT07387666Written as Acetadote
- To Evaluate the Efficacy and Safety of N-acetyl Cysteine Administration in Patients With Diabetic RetinopathyRecruitingPhase 4Ain Shams UniversityNCT07634991Written as N Acetyl cysteine, 1200mg (high dose)
- PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic HepatitisRecruitingPhase 3University Hospital, LilleNCT06956482Written as N-Acetylcysteine (NAC) Treatment
See all 459 studies that test Acetylcysteine →
Given beside what is tested · 23 — Acetylcysteine is usual care or a partner of the new treatment
- Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in SchizophreniaRecruitingPhase 2Amit LotanNCT07759895Written as N-Acetyl Cysteine (NAC)
- Efficacy of Rifaximin With NAC in IBS-DRecruitingPhase 2Mark Pimentel, MDNCT06727422Written as RNIB21 containing rifaximin 132mg + N-acetylcysteine 560mg three times daily
- Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)RecruitingPhase 1/2Biogipuzkoa Health Research InstituteNCT07414212Written as Acetylcysteine
- Comparative PK/PD of FMXIN002 and EpiPen, in Healthy Adults With Allergic RhinitisEnrolling by invitationPhase 1/2Nasus PharmaNCT07228325Written as FMXIN002 single dose + NAC
- Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff RepairNot yet recruitingPhase 4Mahidol UniversityNCT06384833Written as N-acetyl cysteine
- Comparison of Dexamethasone and N Acetylcysteine (NAC) Versus N Acetylcysteine (NAC) Alone in the Prevention of Post Embolization Syndrome in Patients With Hepatocellular Carcinoma Following Transarterial Chemoembolization.Not yet recruitingNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT06039280Written as N Acetylcysteine
- FDOPA PET and Nutritional Support in Parkinson's DiseaseActive, not recruitingPhase 2Thomas Jefferson UniversityNCT04459052Written as N acetyl cysteine
- Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast MaterialCompletedPhase 4University of EdinburghNCT00558142Written as Acetylcysteine
- Study to Evaluate the Feasibility of 13-C Pyruvate Imaging in Breast Cancer Patients Receiving Neoadjuvant ChemotherapyWithdrawnPhase 1Sunnybrook Health Sciences CentreNCT03121989Written as NAC
- Renoprotective Effect of Febuxostat on Contrast Induced Acute Kidney Injury in Chronic Kidney Disease Patients Stage 3CompletedNot applicableAin Shams UniversityNCT05264584Written as N-acetyl cysteine
- Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on HomocystinuriaSuspendedPhase 1/2Hospital de Clinicas de Porto AlegreNCT04015557Written as N-acetylcysteine
- Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19CompletedNot applicableUnidad Temporal COVID-19 en Centro CitibanamexNCT04570254Written as N-acetyl cysteine
- Influence of n-Acetylcysteine Maintenance on Alcohol EffectsCompletedEarly Phase 1William StoopsNCT03216954Written as N-acetyl cysteine
- Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD.CompletedPhase 4Neutec Ar-Ge San ve Tic A.ŞNCT03388853Written as Acetylcysteine/Doxofylline
- High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver FailureCompletedNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT02718079Written as N-acetyl-L-cysteine
- A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)CompletedEarly Phase 1Centre for Addiction and Mental HealthNCT02269540Written as N-acetylcysteine (NAC)
- MK-8237 (SCH900237) Biomarker Study in Participants With Allergic Rhinitis or Rhinoconjunctivitis (MK-8237-009)CompletedPhase 1Merck Sharp & Dohme LLCNCT01852825Written as NAC
- Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver InjuryTerminatedNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT02686385Written as N-Acetylcysteine
- Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney DiseaseCompletedPhase 4VA Greater Los Angeles Healthcare SystemNCT02476526Written as Acetylcysteine Inhalation
- G-CSF Plus NAC In Severe Alcoholic HepatitisStatus unknownPhase 4Post Graduate Institute of Medical Education and Research, ChandigarhNCT02971306Written as n-Acetylcysteine
Showing 20 of 23.
As the comparator · 2 — what is tested is compared with Acetylcysteine
- Povidone-Iodine Nasal Irrigation After Surgery for Chronic RhinosinusitisCompletedNot applicablePusan National University HospitalNCT07470242Written as Acetylcysteine (Mucomyst) Nasal Irrigation
- Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRSCompletedPhase 1Yale UniversityNCT02124941Written as N-acetyl cysteine
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting1
- N-Acetylcysteine in the Management of Spontaneous Bacterial PeritonitisOct 30, 2026NCT07803952
Newly registered4
- Oral N-Acetylcysteine on Diabetic Macular EdemaNov 4, 2026NCT07917338
- N-Acetylcysteine for Bipolar and Alcohol Use DisordersNov 3, 2026NCT07913542
- FEAST and HOPE: Redox PSC Pilot StudyOct 27, 2026NCT07898839
- Antioxidant Supplementation and Muscle Recovery From DOMS in Trained WomenOct 16, 2026NCT07877441
Codes
What other systems call Acetylcysteine · ClinicalTrials.gg INT006895
- MeSH (NLM) D000111AcetylcysteineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) WYQ7N0BPYCACETYLCYSTEINEConfirmed FDA, NLM
- RxNorm 197One source FDA
- NCI Thesaurus C200AcetylcysteineOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000111 | Acetylcysteine | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | WYQ7N0BPYC | ACETYLCYSTEINE | Confirmed FDA, NLM |
| RxNorm | 197 | — | One source FDA |
| NCI Thesaurus | C200 | Acetylcysteine | One source FDA |
Also registered as acetylcysteine sodium (UNII NRD80R06FB · RxNorm 237163).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.