An interventional study of Normal Saline Nasal Irrigation and Acetylcysteine (Mucomyst) Nasal Irrigation in Chronic Rhinosinusitis, sponsored by Pusan National University Hospital. Completed at 1 site in South Korea. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-13.
Sponsored by Pusan National University Hospital · Not applicable, Interventional, and Treatment
This prospective randomized controlled trial evaluates the effectiveness and safety of different nasal irrigation solutions for postoperative care after endoscopic sinus surgery in patients with chronic rhinosinusitis. Patients undergoing endoscopic sinus surgery will be randomly assigned to receive nasal irrigation with normal saline, mucomyst, or diluted povidone-iodine solution for three months after surgery. Clinical outcomes, symptom scores, endoscopic findings, and potential ototoxic effects will be evaluated to compare the effectiveness and safety of these irrigation methods.
Chronic rhinosinusitis is a common inflammatory disease characterized by symptoms such as nasal obstruction, nasal discharge, facial pressure, and decreased sense of smell. Endoscopic sinus surgery (ESS) is often performed in patients whose symptoms do not improve with medical treatment. Postoperative nasal irrigation is widely used to promote mucosal healing and remove secretions in the nasal cavity and paranasal sinuses.
Povidone-iodine has broad-spectrum antimicrobial activity and is commonly used as a disinfectant. It has been suggested that diluted povidone-iodine solution may improve postoperative wound healing and provide additional antimicrobial effects when used as a nasal irrigation solution. However, concerns exist regarding the potential ototoxicity of povidone-iodine if it enters the middle ear during irrigation.
This prospective randomized controlled trial aims to evaluate the effectiveness and safety of nasal irrigation using normal saline, mucomyst, or diluted povidone-iodine solution after endoscopic sinus surgery in patients with chronic rhinosinusitis. Patients will receive nasal irrigation for three months after surgery. Clinical outcomes, symptom scores, endoscopic findings, and hearing-related tests including pure tone audiometry, tympanometry, and distortion product otoacoustic emissions will be evaluated to assess treatment effectiveness and potential ototoxicity.
Pusan National University Hospital is the lead sponsor of 78 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients perform nasal irrigation using normal saline solution for 3 months after endoscopic sinus surgery.
Other: Normal Saline Nasal Irrigation
Patients perform nasal irrigation using a mucomyst solution for 3 months after endoscopic sinus surgery.
Drug: Acetylcysteine (Mucomyst) Nasal Irrigation
Postoperative nasal irrigation using diluted 0.5% povidone-iodine solution after endoscopic sinus surgery.
Drug: Povidone-Iodine Nasal Irrigation
Postoperative nasal irrigation using normal saline solution for 3 months after endoscopic sinus surgery.
Postoperative nasal irrigation using acetylcysteine solution for 3 months after endoscopic sinus surgery.
Postoperative nasal irrigation using diluted 0.5% povidone-iodine solution for 3 months after endoscopic sinus surgery.
Lund-Kennedy Endoscopic Score
Postoperative sinonasal status evaluated by nasal endoscopy using the Lund-Kennedy endoscopic scoring system.
Time frame: 3 months after endoscopic sinus surgery
Hearing function assessed by pure tone audiometry (PTA)
Assessment of hearing threshold to evaluate potential ototoxicity of nasal irrigation solutions.
Time frame: 3 months after endoscopic sinus surgery
Sino-Nasal Outcome Test (SNOT-20) score
Patient-reported sinonasal symptoms and disease-specific quality of life assessed using the Sino-Nasal Outcome Test-20 questionnaire.
Time frame: 3 months after endoscopic sinus surgery
Distortion Product Otoacoustic Emission (DPOAE)
Assessment of hearing threshold to evaluate potential ototoxicity of nasal irrigation solutions.
Time frame: 3 months after endoscopic sinus surgery
Plan to share: Undecided
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Pusan National University Hospital