Liver Failure, Acute clinical trials
The registry lists 96 studies for Liver Failure, Acute across more than 10 countries. 20 are recruiting or about to start. 63 of them are mainly about Liver Failure, Acute (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03. Counting its narrower condition Acute-On-Chronic Liver Failure too: 247 studies, 76 open.
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Who runs them
Institute of Liver and Biliary Sciences, India (12) · Assistance Publique - Hôpitaux de Paris (4) · Rigshospitalet, Denmark (4) · Vital Therapies, Inc. (4) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Sinew Pharma Inc. (3) · William Lee (2) · University of Pittsburgh (2)
What is being tested here
Drugs under test in Liver Failure, Acute studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10
- Nov 2026Biomarkers in Liver Failure · University of Edinburgh
- Dec 2026To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen Overdose · Sinew Pharma Inc.
- Dec 2026ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF · Institute for Clinical and Experimental Medicine
- Dec 2026Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children · Institute of Liver and Biliary Sciences, India
- Dec 2026Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe · University Medical Center Groningen
- Dec 2026Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure · Institute of Liver and Biliary Sciences, India
- May 2027Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis · Assistance Publique - Hôpitaux de Paris
- Sep 2027Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis · University of Cambridge
- Sep 2027Risk Factors and Outcomes of Hepatitis A in Children · Assiut University
- Oct 2027Prevalence and Prognosis of Drug-Induced Liver Injury · Assiut University
Who these studies take
Of the 8 Liver Failure, Acute studies recruiting now, 3 (38%) set no upper age limit and 5 (63%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (25%) | 2 (25%) |
| 18 | 6 (75%) | 6 (75%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 4 (50%) | 4 (50%) |
| 75 | 4 (50%) | 4 (50%) |
| 85 | 3 (38%) | 3 (38%) |
Across all 96 studies, recruiting or not: 51% stop at 75 or younger and 33% at 65; 36% take children; 1% are for women only and 0% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 96. Browse all 96 → or search them.
- Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in EuropeRecruitingNCT0758589010 countries
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Risk Factors and Outcomes of Hepatitis A in ChildrenNot yet recruitingNCT07848321
- Prevalence and Prognosis of Drug-Induced Liver InjuryNot yet recruitingNCT07830901
- Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver FailureRecruitingNCT07765823Not applicable1 country
- Etiology and Prognostic Factors in Patients With Acute Liver FailureNot yet recruitingNCT07556055
- ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLFRecruitingNCT07329036Not applicable1 country
- Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver FailureRecruitingNCT06831643Not applicable1 country
- F573 for Injection for the Treatment of Liver Injury/FailureRecruitingNCT05689645Phase 21 country
- High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral EdemaNot yet recruitingNCT06515145Not applicable1 country
- Transcriptional Analysis of Mechanisms in Liver Failure and SepsisNot yet recruitingNCT071319691 country
- Continuous Renal Replacement Therapy Intensity in HyperammonemiaEnrolling by invitationNCT06987604Not applicable1 country
- Clinical Study of Pediatric Acute Liver FailureEnrolling by invitationNCT068930421 country
- Etiology and Prognostic Analysis of Acute Liver Failure in Chinese ChildrenNot yet recruitingNCT06778941
- Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in ChildrenNot yet recruitingNCT06698991Not applicable1 country
- A Partial Randomized, Single-blind or Open-label, Dose-escalation With Multiple-dose Design Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With Panadol® and SafeTynadol® in Healthy VolunteersRecruitingNCT05563961Not applicable1 country
- Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune HepatitisNot yet recruitingNCT05473403Not applicable1 country
- To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen OverdoseRecruitingNCT05557448Phase 21 country
- Robotic vs. Laparoscopic vs. Open Living Donor HepatectomyEnrolling by invitationNCT060627061 country
- Hepatocyte Microbeads for Acute Liver FailureNot yet recruitingNCT05491135Phase 1/2
- TReatment for ImmUne Mediated PathopHysiologyActive, not recruitingNCT04862221Phase 21 country
- Biomarkers in Liver FailureActive, not recruitingNCT02833064
- Outcomes Using MARS for Patients With ALFCompletedNCT055949531 country
- Longitudinal Study of Mitochondrial HepatopathiesSuspendedNCT011485502 countries
- miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 TrialCompletedNCT06285253Phase 11 country
- Comparison of Two Liver Dialysis Systems : MARS Versus SPAD in Severe Liver FailureCompletedNCT02310542Not applicable1 country
- Plasma Exchange for Amanita Toxin-induced Acute Liver FailureCompletedNCT061872205 countries
- Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver FailureActive, not recruitingNCT06872372Not applicable1 country
- Correlation of Blood Gene Expression (TruGraf Liver) With Liver Biopsy in Pediatric Liver Transplant RecipientsTerminatedNCT062631141 country
- Endoscopic Ultrasound Guided Liver Biopsy and Portal Pressure RegistryWithdrawnNCT05817994
- Prevention of Recurrent Hepatitis B After Liver TransplantationCompletedNCT000592671 country
- Maternal And Fetal Outcomes in Pregnant Women With Liver DiseaseCompletedNCT065942371 country
- Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic EncephalopathyWithdrawnNCT05772585
- Evaluation of Cardiac Function in Acutely Decompensated CirrhosisActive, not recruitingNCT054130831 country
- The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver FailureWithdrawnNCT05940610Phase 1/21 country
- Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic FailureTerminatedNCT015820871 country
- A Randomized, Single-blind, Parallel Group and Multiple - Dose Design StudyCompletedNCT03451487Not applicable1 country
- Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure.Status unknownNCT05778461Not applicable1 country
- Cardiac Risk Assessment Using Standard of Care Versus CTA and Heart Flow FFRctWithdrawnNCT04089969Not applicable
- Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRTCompletedNCT04959110Not applicable1 country
- Safety Study of Stemchymal® in Acute Liver FailureWithdrawnNCT03629015Phase 11 country
- Mesenchymal Stem Cells After Renal or Liver TransplantationCompletedNCT01429038Phase 1/21 country
- A Multi-Center Trial to Study Acute Liver Failure in AdultsCompletedNCT005184402 countries
- Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.Status unknownNCT046218121 country
- To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral EdemaStatus unknownNCT04991259Not applicable1 country
- Emergency Use of OCR-002 in Acute Liver Failure (ALF)No longer availableNCT016342301 country
- HEpatic Regeneration With COupled Plasma Filtration and Adsorption for Liver Extracorporeal DetoxificationCompletedNCT03312036Not applicable1 country
- Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of ParisStatus unknownNCT046584071 country
- 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALFCompletedNCT02786836Phase 2/31 country
- One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort StudyCompletedNCT04570800