Drug
Acetylcysteine clinical trials
Also written NAC, Acetadote and Mucomyst.
- studies test it
- 450
- open now
- 62
- in phase 3
- 88
- first study started
- 1998
Keep track of what changes. Save the Acetylcysteine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
446 studies that test it; most in 2023 (27); 1 more planned to start later
| Year | Studies |
|---|---|
| 1998 | 2 |
| 2000 | 3 |
| 2002 | 4 |
| 2003 | 7 |
| 2004 | 7 |
| 2005 | 10 |
| 2006 | 16 |
| 2007 | 21 |
| 2008 | 14 |
| 2009 | 15 |
| 2010 | 18 |
| 2011 | 20 |
| 2012 | 14 |
| 2013 | 20 |
| 2014 | 19 |
| 2015 | 19 |
| 2016 | 22 |
| 2017 | 21 |
| 2018 | 24 |
| 2019 | 20 |
| 2020 | 17 |
| 2021 | 26 |
| 2022 | 23 |
| 2023 | 27 |
| 2024 | 22 |
| 2025 | 17 |
| 2026 | 18 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 25
- Phase 1
- 64
- Phase 2
- 170
- Phase 3
- 88
- Phase 4
- 67
- No phase
- 90
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 19 · Other 431
Medical University of South Carolina (19) · Ain Shams University (16) · Peking University People's Hospital (9) · Yale University (9) · University of Minnesota (8) · Stanford University (8) · Tanta University (7) · Baylor College of Medicine (5)
Often tested with
Tested in the same studies.
Sodium Bicarbonate (6) · Thioctic Acid (5) · Vitamin E (5) · Simethicone (4) · Ascorbic Acid (4) · Dexamethasone (4) · Glycine (3) · Creatine (2)
Studies
Open first, then newest update. How each study uses Acetylcysteine is read from its arms, and is right about nine times in ten.
Testing it · 450
- Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and PneumoniaRecruitingPhase 3Chinese University of Hong KongNCT03900988Written as N-acetyl cysteine
- NAC for Hematopoietic Recovery in Low/Intermediate-Risk AML After CR: A Randomized Controlled StudyNot yet recruitingNot applicablePeking University People's HospitalNCT07869342Written as N-acetyl-L-cysteine (NAC)
- Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia PatientsNot yet recruitingPhase 3Peking University People's HospitalNCT07737262Written as N-acetylcysteine
- Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-AcetylcysteineRecruitingPhase 4Theis S. ItenovNCT07273071Written as N-Acetylcysteine (NAC) Treatment
- N-Acetylcysteine in the Management of Spontaneous Bacterial PeritonitisNot yet recruitingPhase 1/2Tanta UniversityNCT07803952Written as NAC
- Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal DystrophyRecruitingPhase 2Massachusetts Eye and Ear InfirmaryNCT04440280Written as N-acetyl cysteine (NAC) 10% solution
- Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung DiseaseRecruitingPhase 2David PalmaNCT05986318Written as N-Acetyl cysteine
- Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver FailureRecruitingNot applicableKing Edward Medical UniversityNCT07765823Written as N Acetyl Cysteine
- Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange SyndromeNot yet recruitingPhase 2Johns Hopkins UniversityNCT04381897Written as N-acetyl cysteine
- NAC-REPAIR for Post-surgical PainNot yet recruitingPhase 2University of ArizonaNCT07227649Written as NAC
- Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBTRecruitingPhase 1/2University of California, IrvineNCT04520139Written as N-Acetyl-Cysteine
- An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard TherapyRecruitingPhase 2Fudan UniversityNCT07117630Written as N-Acetylcysteine (NAC) Treatment
- Effect of Acetylcysteine Inhalation on Incidence and Time to Develop Ventilator Associated Pneumonia in Critically Ill Mechanically Ventilated PatientsRecruitingPhase 4Cairo UniversityNCT07409727Written as Acetyl cysteine
- Imaging Acetadote Metabolism in GlioblastomaRecruitingEarly Phase 1University of Texas Southwestern Medical CenterNCT07387666Written as Acetadote
- To Evaluate the Efficacy and Safety of N-acetyl Cysteine Administration in Patients With Diabetic RetinopathyRecruitingPhase 4Ain Shams UniversityNCT07634991Written as N Acetyl cysteine, 1200mg (high dose)
- PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic HepatitisRecruitingPhase 3University Hospital, LilleNCT06956482Written as N-Acetylcysteine (NAC) Treatment
- Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open LabelEnrolling by invitationPhase 2/3Stanford UniversityNCT05494398Written as N-acetylcysteine
- Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: TrialRecruitingPhase 2/3Stanford UniversityNCT05664789Written as N acetyl cysteine
- Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-doseRecruitingPhase 2Stanford UniversityNCT04278898Written as N-Acetylcysteine
- Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)RecruitingPhase 4University of Missouri-ColumbiaNCT03652753Written as N-acetylcysteine
See all 450 studies that test Acetylcysteine →
Given in every arm · 18 — Acetylcysteine is usual care beside what is tested
- Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in SchizophreniaRecruitingPhase 2Amit LotanNCT07759895Written as N-Acetyl Cysteine (NAC)
- Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff RepairNot yet recruitingPhase 4Mahidol UniversityNCT06384833Written as N-acetyl cysteine
- Comparison of Dexamethasone and N Acetylcysteine (NAC) Versus N Acetylcysteine (NAC) Alone in the Prevention of Post Embolization Syndrome in Patients With Hepatocellular Carcinoma Following Transarterial Chemoembolization.Not yet recruitingNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT06039280Written as N Acetylcysteine
- FDOPA PET and Nutritional Support in Parkinson's DiseaseActive, not recruitingPhase 2Thomas Jefferson UniversityNCT04459052Written as N acetyl cysteine
- Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast MaterialCompletedPhase 4University of EdinburghNCT00558142Written as Acetylcysteine
- Study to Evaluate the Feasibility of 13-C Pyruvate Imaging in Breast Cancer Patients Receiving Neoadjuvant ChemotherapyWithdrawnPhase 1Sunnybrook Health Sciences CentreNCT03121989Written as NAC
- Renoprotective Effect of Febuxostat on Contrast Induced Acute Kidney Injury in Chronic Kidney Disease Patients Stage 3CompletedNot applicableAin Shams UniversityNCT05264584Written as N-acetyl cysteine
- Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19TerminatedPhase 1Prisma Health-UpstateNCT04545008Written as N-Acetyl cysteine
- Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19CompletedNot applicableUnidad Temporal COVID-19 en Centro CitibanamexNCT04570254Written as N-acetyl cysteine
- Influence of n-Acetylcysteine Maintenance on Alcohol EffectsCompletedEarly Phase 1William StoopsNCT03216954Written as N-acetyl cysteine
- High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver FailureCompletedNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT02718079Written as N-acetyl-L-cysteine
- A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)CompletedEarly Phase 1Centre for Addiction and Mental HealthNCT02269540Written as N-acetylcysteine (NAC)
- MK-8237 (SCH900237) Biomarker Study in Participants With Allergic Rhinitis or Rhinoconjunctivitis (MK-8237-009)CompletedPhase 1Merck Sharp & Dohme LLCNCT01852825Written as NAC
- Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver InjuryTerminatedNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT02686385Written as N-Acetylcysteine
- Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney DiseaseCompletedPhase 4VA Greater Los Angeles Healthcare SystemNCT02476526Written as Acetylcysteine Inhalation
- G-CSF Plus NAC In Severe Alcoholic HepatitisStatus unknownPhase 4Post Graduate Institute of Medical Education and Research, ChandigarhNCT02971306Written as n-Acetylcysteine
- Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based TherapyStatus unknownPhase 2/3Hadassah Medical OrganizationNCT02882477Written as Acetylcysteine
- Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)CompletedPhase 4University of EdinburghNCT01050270Written as acetylcysteine
As the comparator · 2 — what is tested is compared with Acetylcysteine
- Povidone-Iodine Nasal Irrigation After Surgery for Chronic RhinosinusitisCompletedNot applicablePusan National University HospitalNCT07470242Written as Acetylcysteine (Mucomyst) Nasal Irrigation
- Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRSCompletedPhase 1Yale UniversityNCT02124941Written as N-acetyl cysteine
Codes
What other systems call Acetylcysteine · ClinicalTrials.gg INT006895
- MeSH (NLM) D000111AcetylcysteineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) WYQ7N0BPYCACETYLCYSTEINEConfirmed FDA, NLM
- RxNorm 197One source FDA
- NCI Thesaurus C200AcetylcysteineOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000111 | Acetylcysteine | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | WYQ7N0BPYC | ACETYLCYSTEINE | Confirmed FDA, NLM |
| RxNorm | 197 | — | One source FDA |
| NCI Thesaurus | C200 | Acetylcysteine | One source FDA |
Also registered as acetylcysteine sodium (UNII NRD80R06FB · RxNorm 237163).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.