Endotoxemia clinical trials
The registry lists 81 studies for Endotoxemia across more than 10 countries. 7 are recruiting or about to start. 41 of them are mainly about Endotoxemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-13.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Radboud University Medical Center (21) · University of Aarhus (5) · Spectral Diagnostics (US) Inc. (4) · Laval University (4) · Rigshospitalet, Denmark (4) · Ohio State University (4) · Medical University of Vienna (3) · University of Vienna (3)
What is being tested here
Drugs under test in Endotoxemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Mar 2027Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function · Universitaire Ziekenhuizen KU Leuven
- Jun 2027Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation · Moscow Multidisciplinary Clinical Center "Kommunarka"
- Sep 2027OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · Pauls Stradins Clinical University Hospital
Who these studies take
Of the 6 Endotoxemia studies recruiting now, 2 (33%) set no upper age limit and 3 (50%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 1 (17%) for men only; 4 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (83%) | 6 (100%) |
| 30 | 5 (83%) | 6 (100%) |
| 40 | 5 (83%) | 5 (83%) |
| 50 | 3 (50%) | 3 (50%) |
| 65 | 3 (50%) | 3 (50%) |
| 75 | 3 (50%) | 3 (50%) |
| 85 | 2 (33%) | 2 (33%) |
Across all 81 studies, recruiting or not: 75% stop at 75 or younger and 65% at 65; 1% take children; 1% are for women only and 44% for men only; 74% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Endotoxemia studies take
Of 31 interventional studies with no phase under Endotoxemia, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo8–26 · 31 studies | — | 17 mo8–25 · 29 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 81. Browse all 81 → or search them.
- Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive FunctionRecruitingNCT07713641Not applicable1 country
- Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety EvaluationNot yet recruitingNCT07661303Not applicable1 country
- OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) StudyRecruitingNCT074198021 country
- Different Dietary PatternsRecruitingNCT06147440Not applicable1 country
- Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human EndotoxemiaRecruitingNCT06624436Phase 41 country
- Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)RecruitingNCT04920565Not applicable1 country
- The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive DisorderRecruitingNCT062030151 country
- Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label StudyCompletedNCT03901807Not applicable1 country
- Gut-level Antiinflammatory Activities of Green Tea in Metabolic SyndromeCompletedNCT03973996Not applicable1 country
- Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive ComponentsActive, not recruitingNCT05318183Not applicable1 country
- Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk PreventionCompletedNCT04190706Not applicable1 country
- Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).Active, not recruitingNCT07182370Not applicable1 country
- Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic SyndromeCompletedNCT03624569Not applicable1 country
- Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese AdultsCompletedNCT03413735Not applicable1 country
- Determining the Fingerprint of Endotoxin ToleranceCompletedNCT06801873Not applicable1 country
- Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic IndexesTerminatedNCT06630572Phase 41 country
- The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.CompletedNCT064032411 country
- Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic SyndromeCompletedNCT04117802Not applicable1 country
- Elevated Levels of Antibodies to Endotoxin Core in Hemodialysis Patients With Peripheral Artery DiseaseCompletedNCT057529681 country
- Dietary Intervention to Reduce Metabolic EndotoxemiaCompletedNCT05776329Not applicable1 country
- Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier FunctionCompletedNCT04788680Not applicable1 country
- Effect of Cranberry and Agaves Extract on Microbiota and Intestinal HealthCompletedNCT03800277Not applicable1 country
- Remove LPS RegistryWithdrawnNCT05260099
- The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor CellsCompletedNCT05570643Not applicable1 country
- Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in HumansCompletedNCT04130321Not applicable1 country
- The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric SurgeryStatus unknownNCT05407090Not applicable1 country
- Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19No longer availableNCT043529851 country
- Open-label Evaluation of Polymyxin B Hemoperfusion for Septic ShockTemporarily not availableNCT02825329
- ENDOCUR - Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight AdultsCompletedNCT03329781Not applicable
- Foodprint 1.0: Physiological Acute Responses After Consumption of Confectionary ProductsCompletedNCT03972878Not applicable1 country
- Cereals and Intestinal FunctionCompletedNCT04019457Not applicable1 country
- Echocardiographic Changes After 3-hydroxy Butyrate+Whey IntakeCompletedNCT04037722Not applicable1 country
- Anabolic Potential of 3-hydroxybutyrate (3-OHB) and Whey Protein in a Human Catabolic Inflammatory Disease ModelCompletedNCT04064268Not applicable1 country
- Gastro-intestinal and Hormonal Responses to Systemic Inflammatory DiseaseCompletedNCT04056286Not applicable1 country
- Effects of Cranberry Powder Supplements on Gut Microbiota Diversity and Metabolic SyndromeCompletedNCT03754504Not applicable1 country
- Vorapaxar in the Human Endotoxemia ModelCompletedNCT02875028Phase 41 country
- Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of DefibrotideCompletedNCT02876601Phase 41 country
- The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human EndotoxemiaCompletedNCT02922673Not applicable1 country
- Whey vs Casein to Combat Post-inflammatory Protein and Muscle Waste in Acute DiseaseCompletedNCT03319550Not applicable1 country
- Effect of Monosaccharides on Intestinal Barrier FunctionCompletedNCT03482284Not applicable
- Effects of Cold Exposure and Breathing Techniques on Immune ResponseCompletedNCT03240497Not applicable1 country
- Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic ShockCompletedNCT01046669Not applicable2 countries
- A New Model of Acute Febrile DiseaseCompletedNCT03158363Not applicable1 country
- Influence of Probiotics Administration Before Liver Resection in Liver DiseaseCompletedNCT02021253Not applicable1 country
- Effects of Vasopressors on Immune ResponseCompletedNCT02675868Phase 41 country
- PK/PD of EA-230 During EndotoxemiaCompletedNCT02629874Phase 11 country
- Results of Bile and Blood Culture in Patients With Acute CholangitisTerminatedNCT021075601 country
- The Effect of a Bifidobacterium and Polydextrose on Body Fat MassCompletedNCT01978691Phase 21 country
- The Role of the Gut Microbiota in the Systemic Immune Response During Human EndotoxemiaCompletedNCT02127749Not applicable1 country
- Ticagrelor in Human Endotoxemia Response to Human EndotoxemiaCompletedNCT02612480Not applicable1 country