Sarcoma clinical trials
The registry lists 1,607 studies for Sarcoma across more than 10 countries. 366 are recruiting or about to start. 795 of them are mainly about Sarcoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 22 narrower conditions too, such as Osteosarcoma: 2,546 studies, 611 open.
ClinicalTrials.gov finds 3,090 studies for Sarcoma. How that becomes 1,607 here
This page counts the studies the registry files under Sarcoma, and those it files under no condition that list Sarcomathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 3,090Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −876Filed under a narrower condition, counted on its own pageOsteosarcoma 278 · Sarcoma, Kaposi 122 · Sarcoma, Ewing 87 · Rhabdomyosarcoma 55 · Leiomyosarcoma 51 · Liposarcoma 36 · 16 more
- −186List Sarcoma as a condition, but the registry did not file them under itMost often written as “Uterine Sarcoma” (14), “Retroperitoneal Sarcoma” (12), and “Ovarian Sarcoma” (11). The registry filed 77 of them under no condition at all, and the others under other conditions only, most often Uterine Cervical Neoplasms (15) and Endometrial Neoplasms (15).
- −421Match it another way72 name it in the title, 54 in a keyword, and 295 by a synonym or other text the search reads.
- 1,607The count on this page
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Cancer Institute (NCI) (115) · Memorial Sloan Kettering Cancer Center (64) · M.D. Anderson Cancer Center (47) · Children's Oncology Group (44) · European Organisation for Research and Treatment of Cancer - EORTC (22) · Institut Bergonié (22) · Washington University School of Medicine (19) · Dana-Farber Cancer Institute (19)
What is being tested here
Drugs under test in Sarcoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Doxorubicin | 13 | 12 | 65 |
| Trabectedin | 6 | 5 | 28 |
| Pembrolizumab | 6 | 0 | 20 |
| Nivolumab | 6 | 1 | 19 |
| Anlotinib | 5 | 2 | 18 |
| Ifosfamide | 4 | 12 | 46 |
| Pazopanib | 4 | 2 | 29 |
| Atezolizumab | 4 | 0 | 8 |
| Oncolytic HSV-1 R130 | 4 | 0 | 5 |
| Tetrachloroethane | 4 | 0 | 5 |
Drug classes tested here Immune checkpoint inhibitors 34 open · Tyrosine kinase inhibitors (TKIs) 26 open · Alkylating agents 9 open · Antimetabolites 5 open · Antimitotic agents 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas · Phase 3 · Institut Bergonié
- Oct 2027Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy · Phase 3 · Memorial Sloan Kettering Cancer Center
- Nov 2026PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study · Memorial Sloan Kettering Cancer Center
- Nov 2026Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma · Memorial Sloan Kettering Cancer Center
- Nov 2026GRID Therapy for Extremity Soft Tissue Sarcoma · UNC Lineberger Comprehensive Cancer Center
- Nov 2026Cryoablation Plus Camrelizumab for Advanced Soft Tissue Sarcoma · Sun Yat-sen University
- Dec 2026Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors · Bambino Gesù Hospital and Research Institute
- Dec 2026Lurbinectedin + Doxorubicin In Leiomyosarcoma · Massachusetts General Hospital
- Dec 2026Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) · Fox Chase Cancer Center
- Dec 2026Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract · Memorial Sloan Kettering Cancer Center
Who these studies take
Of the 301 Sarcoma studies recruiting now, 191 (63%) set no upper age limit and 83 (28%) stop at 75 or younger. 91 (30%) take children under 18. 4 (1%) are for women only and 0 (0%) for men only; 12 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 60 (20%) | 60 (20%) |
| 18 | 288 (96%) | 284 (94%) |
| 30 | 279 (93%) | 275 (91%) |
| 40 | 266 (88%) | 263 (87%) |
| 50 | 256 (85%) | 254 (84%) |
| 65 | 257 (85%) | 255 (85%) |
| 75 | 239 (79%) | 237 (79%) |
| 85 | 211 (70%) | 210 (70%) |
Across all 1,607 studies, recruiting or not: 27% stop at 75 or younger and 19% at 65; 36% take children; 2% are for women only and <1% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sarcoma studies take
Of 227 phase 2 interventional studies under Sarcoma, half reached primary completion within 66 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 56 mo35–72 · 161 studies | 52 mo36–66 · 72 studies | 62 mo34–77 · 89 studies |
| Phase 1/2 | 62 mo45–106 · 101 studies | 59 mo43–89 · 44 studies | 71 mo51–117 · 57 studies |
| Phase 2 | 66 mo43–92 · 227 studies | — | 66 mo46–91 · 198 studies |
| Phase 3 | 105 mo50–155 · 24 studies | — | — |
| Interventional, no phase | 59 mo34–120 · 147 studies | — | 61 mo34–120 · 144 studies |
| Observational | 66 mo42–294 · 97 studies | — | 72 mo42–294 · 88 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
- Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric PatientsNov 2, 2026NCT07658768
- PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility StudyOct 20, 2026NCT07874828
Results posted4
- Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign DiseaseNov 5, 2026NCT01552434
- Neoadjuvant Durvalumab and Tremelimumab Plus Radiation for High Risk Soft-Tissue SarcomaNov 5, 2026NCT03116529
- A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical StudyOct 28, 2026NCT02875548
- Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative CancersOct 20, 2026NCT04416568
Stopped5
- Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid TumorsTerminatedNov 10, 2026NCT05075993
- A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical StudyTerminatedOct 28, 2026NCT02875548
- Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)WithdrawnOct 26, 2026NCT06712433
- Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult ParticipantsTerminatedOct 16, 2026NCT06566092
- Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue SarcomasSuspendedOct 14, 2026NCT07052383
Newly registered7
- Evaluation of the I-phase Clinical Trial of 177Lu-HX02 Injection in Patients With Advanced Malignant Solid TumorsNov 6, 2026NCT07920822
- A Multicenter Phase II Clinical Trial Evaluating 68Ga-HX01 Injection for PET/CT ImagingNov 6, 2026NCT07920835
- Zemetostat With Anlotinib in Patients With Recurrent/Metastatic Head and Neck Soft Tissue SarcomaNov 5, 2026NCT07917949
- Exercise Rehabilitation to Improve Long-term Outcomes in Sarcoma Survivors.Oct 23, 2026NCT07893041
- Preliminary Clinical Study of Entinostat in Children With Malignant Soft Tissue Sarcoma Harboring PAX-family Gene AbnormalitiesOct 22, 2026NCT07888114
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- Surgical Margin Assessment Using Intra-operative High-resolution PET/CT in Patients With Cancers Referred to Surgical Resection, an Exploratory Pilot StudyOct 20, 2026NCT07884487
- PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility StudyOct 15, 2026NCT07874828
Studies
Recruiting first, then most recently updated. Showing 50 of 1,607. Browse all 1,607 → or search them.
- Analysis of Circulating Tumor Markers in BloodRecruitingNCT04025541Not applicable1 country
- START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of CancerRecruitingNCT05492682Phase 12 countries
- A Multicenter Phase II Clinical Trial Evaluating 68Ga-HX01 Injection for PET/CT ImagingRecruitingNCT07920835Phase 21 country
- Evaluation of the I-phase Clinical Trial of 177Lu-HX02 Injection in Patients With Advanced Malignant Solid TumorsEnrolling by invitationNCT07920822Phase 11 country
- Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing SarcomaRecruitingNCT05734066Phase 1/22 countries
- Anti-GD2 ADC M3554 in Advanced Solid TumorsRecruitingNCT06641908Phase 16 countries
- Zemetostat With Anlotinib in Patients With Recurrent/Metastatic Head and Neck Soft Tissue SarcomaRecruitingNCT07917949Phase 21 country
- Distance-Based Exercise to Preserve Function and Prevent DisabilityRecruitingNCT07059884Not applicable1 country
- Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic SarcomaRecruitingNCT05726383Phase 21 country
- A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)RecruitingNCT06760819Phase 211 countries
- Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced SarcomaRecruitingNCT05711615Phase 11 country
- cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual DiseaseRecruitingNCT053668811 country
- Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...RecruitingNCT02390752Phase 11 country
- T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.RecruitingNCT06474676Phase 11 country
- Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue SarcomaRecruitingNCT07283731Phase 21 country
- Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma PatientsRecruitingNCT072279612 countries
- Combination Immunotherapy Targeting SarcomasNot yet recruitingNCT04433221Phase 1/21 country
- Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer PatientsAvailableNCT05974410
- Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric PatientsRecruitingNCT07658768Early Phase 11 country
- Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting SarcomasNot yet recruitingNCT03356782Phase 1/21 country
- my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young AdultsNot yet recruitingNCT07516353Not applicable1 country
- 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer DetectionRecruitingNCT06503146Phase 21 country
- A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 13 countries
- Lead-212 PSV359 Therapy for Patients With Solid TumorsRecruitingNCT06710756Phase 1/21 country
- A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell SarcomaRecruitingNCT06942442Phase 22 countries
- A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid TumorsRecruitingNCT07705334Phase 11 country
- Preliminary Clinical Study of Entinostat in Children With Malignant Soft Tissue Sarcoma Harboring PAX-family Gene AbnormalitiesRecruitingNCT07888114Phase 11 country
- STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected SarcomasRecruitingNCT06975293Phase 1/21 country
- Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue SarcomaRecruitingNCT06498648Phase 1/21 country
- LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy and Spectroscopy-based Molecular Urinalysis in Sarcoma PatientsRecruitingNCT069581071 country
- Sequential Neoadjuvant Chemotherapy in Soft Tissue SarcomaRecruitingNCT04776525Phase 21 country
- PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility StudyRecruitingNCT07874828Phase 21 country
- FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory RhabdomyosarcomaRecruitingNCT06865664Phase 11 country
- Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue SarcomaRecruitingNCT04307277Phase 31 country
- Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT TrialRecruitingNCT07650656Phase 21 country
- Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological StudiesRecruitingNCT011093941 country
- Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma ClinicRecruitingNCT06805773Not applicable1 country
- Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue SarcomaRecruitingNCT06980259Not applicable1 country
- Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid TumorsRecruitingNCT07261631Phase 17 countries
- A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue SarcomaRecruitingNCT07741877Phase 21 country
- LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic OncologyEnrolling by invitationNCT03244020Phase 41 country
- CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.RecruitingNCT02789384Not applicable1 country
- Sarcoma Care Adherence and Survival in StrasbourgRecruitingNCT078648701 country
- A Study of ONO-4538HSC in Pediatric Patients With Malignant Solid Tumors and in Patients With Epithelioid Sarcoma.RecruitingNCT07734116Phase 1/21 country
- Paediatric Sarcoma, Hybrid Imaging & FAPI - Raising the Diagnostic Standard for Paediatric Sarcoma Patients, Combining Novel Radiotracer FAPI and Whole-body PET/MRINot yet recruitingNCT07861217Phase 21 country
- Prospective Registry of Histotripsy for Soft Tissue TumorsEnrolling by invitationNCT074700081 country
- Molecular and Clinical Studies of Bone and Soft Tissue TumorsRecruitingNCT078222041 country
- 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid TumorsRecruitingNCT07189871Phase 1/21 country
- HTL0039732 in Participants With Advanced Solid TumoursRecruitingNCT05944237Phase 1/21 country
- Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced LeiomyosarcomaRecruitingNCT06528769Phase 21 country