Leiomyosarcoma clinical trials
The registry lists 177 studies for Leiomyosarcoma across more than 10 countries. 35 are recruiting or about to start. 73 of them are mainly about Leiomyosarcoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Cancer Institute (NCI) (20) · European Organisation for Research and Treatment of Cancer - EORTC (15) · Memorial Sloan Kettering Cancer Center (10) · M.D. Anderson Cancer Center (6) · Eli Lilly and Company (3) · Dana-Farber Cancer Institute (3) · Gynecologic Oncology Group (3) · UNICANCER (3)
What is being tested here
Drugs under test in Leiomyosarcoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Doxorubicin | 3 | 5 | 17 |
| Trabectedin | 2 | 3 | 12 |
| Liposomal doxorubicin | 2 | 0 | 4 |
| Ifosfamide | 1 | 6 | 9 |
| Pazopanib | 1 | 1 | 8 |
| Selinexor | 1 | 0 | 2 |
| Dacarbazine | 1 | 1 | 2 |
| Peposertib | 1 | 0 | 1 |
| Ivonescimab | 1 | 0 | 1 |
| Abemaciclib | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 4 open · Immune checkpoint inhibitors 3 open · Alkylating agents 2 open · Antimitotic agents 7 · HDAC inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Apr 2027Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
- Nov 2026Localized Leiomyosarcoma Biomarker Protocol · University of Michigan Rogel Cancer Center
- Dec 2026Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) · Fox Chase Cancer Center
- Dec 2026Metastatic Leiomyosarcoma Biomarker Protocol · University of Michigan Rogel Cancer Center
- Dec 2026Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery · National Cancer Institute (NCI)
- Jan 2027The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial Lesions · Charles University, Czech Republic
- Jan 2027Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors · University Health Network, Toronto
- Jan 2027Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma · Jonsson Comprehensive Cancer Center
- Jan 2027Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma · National Cancer Institute (NCI)
- May 2027Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors · University of California, Irvine
Who these studies take
Of the 31 Leiomyosarcoma studies recruiting now, 25 (81%) set no upper age limit and 4 (13%) stop at 75 or younger. 6 (19%) take children under 18. 3 (10%) are for women only and 0 (0%) for men only; 1 (3%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (13%) | 4 (13%) |
| 18 | 30 (97%) | 27 (87%) |
| 30 | 30 (97%) | 27 (87%) |
| 40 | 29 (94%) | 26 (84%) |
| 50 | 29 (94%) | 26 (84%) |
| 65 | 30 (97%) | 27 (87%) |
| 75 | 29 (94%) | 26 (84%) |
| 85 | 27 (87%) | 25 (81%) |
Across all 177 studies, recruiting or not: 11% stop at 75 or younger and 2% at 65; 23% take children; 16% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leiomyosarcoma studies take
Of 41 phase 2 interventional studies under Leiomyosarcoma, half reached primary completion within 62 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 62 mo35–80 · 41 studies | — | 61 mo35–80 · 38 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 177. Browse all 177 → or search them.
- Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced SarcomaRecruitingNCT05711615Phase 11 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected SarcomasRecruitingNCT06975293Phase 1/21 country
- A Study of Ivonescimab in People With LeiomyosarcomaRecruitingNCT07516925Phase 21 country
- Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue SarcomaRecruitingNCT06498648Phase 1/21 country
- AOH1996 for the Treatment of Refractory Solid TumorsRecruitingNCT05227326Phase 11 country
- Phase II Decentralized Pragmatic Trial of Adjuvant Doxorubicin - Trabectedin Chemotherapy in uLMSRecruitingNCT07076186Phase 21 country
- XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue SarcomaRecruitingNCT06571734Phase 21 country
- Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal SarcomaRecruitingNCT04031677Phase 315 countries
- Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced LeiomyosarcomaRecruitingNCT06528769Phase 21 country
- Interest of Post-operative Chemotherapy in Patients With Localised Uterine Leiomyosarcoma Suspected of Having a High Risk of Recurrence Based on a Biological Test Performed on the TumourRecruitingNCT06524583Phase 21 country
- NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)RecruitingNCT06239272Phase 1/21 country
- A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic TherapyRecruitingNCT07633756Phase 11 country
- Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid TumorsRecruitingNCT07628634Early Phase 11 country
- Letrozole in Uterine LeiomyosarcomaRecruitingNCT05649956Phase 21 country
- Localized Leiomyosarcoma Biomarker ProtocolRecruitingNCT049250891 country
- Metastatic Leiomyosarcoma Biomarker ProtocolRecruitingNCT056533882 countries
- A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid TumorsRecruitingNCT06789172Phase 13 countries
- Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)RecruitingNCT03016819Phase 35 countries
- Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma PatientsRecruitingNCT074329321 country
- Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone SarcomasRecruitingNCT04055220Not applicable1 country
- A Trial for Advanced Leiomyosarcoma With Human Organoid-guided Personalized EfficacyEnrolling by invitationNCT07405346Not applicable1 country
- Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic LeiomyosarcomaRecruitingNCT07125183Phase 21 country
- Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue SarcomaRecruitingNCT07169344Phase 21 country
- Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.RecruitingNCT07173972Phase 21 country
- IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS)RecruitingNCT06849986Phase 21 country
- MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue SarcomaRecruitingNCT06277154Phase 21 country
- Beliefs, Attitudes, and Response to Genetic Testing in SarcomaPatientsRecruitingNCT068757001 country
- Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Soft Tissue SarcomaRecruitingNCT04535271Phase 21 country
- Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue SarcomaNot yet recruitingNCT06526897Not applicable
- The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial LesionsNot yet recruitingNCT065210601 country
- A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer AgentsRecruitingNCT05094804Phase 1/21 country
- Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)RecruitingNCT03420014Phase 21 country
- Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma PatientsRecruitingNCT02275286Phase 1/23 countries
- Exploring Clinical Trial Experiences of People With LeiomyosarcomaNot yet recruitingNCT05548179
- Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue SarcomaActive, not recruitingNCT04200443Phase 21 country
- A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or DeletionsActive, not recruitingNCT06308419Phase 11 country
- Agnostic Therapy in Rare Solid TumorsActive, not recruitingNCT06638931Phase 21 country
- Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid TumorsActive, not recruitingNCT03851614Phase 21 country
- Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped WorkingActive, not recruitingNCT05432791Phase 2/32 countries
- Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by SurgeryActive, not recruitingNCT02923778Phase 22 countries
- Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene AmplificationsTerminatedNCT05827614Phase 11 country
- A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine LeiomyosarcomaActive, not recruitingNCT03880019Phase 21 country
- A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated DiseasesActive, not recruitingNCT04554914Phase 27 countries
- A Study of Rucaparib and Nivolumab in People With LeiomyosarcomaActive, not recruitingNCT04624178Phase 21 country
- Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)TerminatedNCT05712694Phase 33 countries
- CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine LeiomyosarcomaCompletedNCT04727242Phase 21 country
- Gemcitabine Hydrochloride and Docetaxel With or Without Bevacizumab in Treating Patients With Advanced or Recurrent Uterine LeiomyosarcomaTerminatedNCT01012297Phase 31 country
- Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)Active, not recruitingNCT06088290Phase 312 countries
- Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryCompletedNCT02180867Phase 2/33 countries