Neurofibrosarcoma clinical trials
The registry lists 98 studies for Neurofibrosarcoma across more than 10 countries. 23 are recruiting or about to start. 19 of them are mainly about Neurofibrosarcoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
National Cancer Institute (NCI) (13) · European Organisation for Research and Treatment of Cancer - EORTC (13) · Memorial Sloan Kettering Cancer Center (5) · Sarcoma Alliance for Research through Collaboration (5) · Novartis Pharmaceuticals (2) · OHSU Knight Cancer Institute (2) · St. Jude Children's Research Hospital (2) · Tango Therapeutics, Inc. (2)
What is being tested here
Drugs under test in Neurofibrosarcoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Selinexor | 2 | 0 | 4 |
| Navlimetostat | 2 | 0 | 2 |
| Doxorubicin | 1 | 5 | 10 |
| Ifosfamide | 1 | 6 | 8 |
| Pazopanib | 1 | 1 | 5 |
| Alrizomadlin | 1 | 0 | 2 |
| AZD 6244 | 1 | 0 | 2 |
| Liposomal doxorubicin | 1 | 0 | 2 |
| RO5126766 | 1 | 0 | 1 |
| Defactinib | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 2 open · Immune checkpoint inhibitors 2 open · Alkylating agents 1 open · mTOR inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Jan 2027A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST] · University of Minnesota
- Jan 2027Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma · Jonsson Comprehensive Cancer Center
- Mar 2027B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) · St. Jude Children's Research Hospital
- Apr 2027A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST) · Memorial Sloan Kettering Cancer Center
- Jun 2027Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors · Tango Therapeutics, Inc.
- Jul 2027Agnostic Therapy in Rare Solid Tumors · Instituto do Cancer do Estado de São Paulo
- Oct 2027Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST · AeRang Kim
Who these studies take
Of the 18 Neurofibrosarcoma studies recruiting now, 10 (56%) set no upper age limit and 5 (28%) stop at 75 or younger. 11 (61%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (39%) | 7 (39%) |
| 18 | 18 (100%) | 18 (100%) |
| 30 | 16 (89%) | 16 (89%) |
| 40 | 15 (83%) | 15 (83%) |
| 50 | 15 (83%) | 15 (83%) |
| 65 | 15 (83%) | 15 (83%) |
| 75 | 14 (78%) | 14 (78%) |
| 85 | 13 (72%) | 13 (72%) |
Across all 98 studies, recruiting or not: 22% stop at 75 or younger and 14% at 65; 50% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Neurofibrosarcoma studies take
Of 18 phase 2 interventional studies under Neurofibrosarcoma, half reached primary completion within 41 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 41 mo32–80 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 98. Browse all 98 → or search them.
- Metarrestin (ML-246) in Subjects With Metastatic Solid TumorsRecruitingNCT04222413Phase 11 country
- Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)RecruitingNCT062222031 country
- Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath TumorNot yet recruitingNCT07743554Phase 2
- A Study of Selinexor in People With Wilms Tumors and Other Solid TumorsRecruitingNCT05985161Phase 21 country
- DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical MarginsRecruitingNCT072980831 country
- Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid TumorsRecruitingNCT05732831Phase 1/23 countries
- Phase 1 Study of MRTX1719 in Solid Tumors With MTAP DeletionRecruitingNCT05245500Phase 11 country
- Neurofibromatosis Type 1 Tumor Early Detection StudyEnrolling by invitationNCT065158601 country
- Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for SarcomasRecruitingNCT05253131Phase 21 country
- SPEARHEAD-3 Pediatric StudyRecruitingNCT05642455Phase 1/21 country
- Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath TumorRecruitingNCT07549022Phase 1/21 country
- NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)RecruitingNCT06239272Phase 1/21 country
- Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNSTRecruitingNCT06735820Phase 1/21 country
- A Study of DEG6498 in Participants With Solid TumorsRecruitingNCT07244835Phase 11 country
- A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST]RecruitingNCT06693284Early Phase 11 country
- B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)RecruitingNCT04897321Phase 11 country
- Multi-Institutional Registry for Malignant Peripheral Nerve Sheath TumorsRecruitingNCT031410215 countries
- BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of BreastAvailableNCT040912951 country
- A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)RecruitingNCT04872543Phase 21 country
- IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS)RecruitingNCT06849986Phase 21 country
- Using CICS-1 and SPM-011 and [18F]FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMAEnrolling by invitationNCT06603987Phase 1/21 country
- MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue SarcomaRecruitingNCT06277154Phase 21 country
- Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue SarcomaNot yet recruitingNCT06526897Not applicable
- Natural History Study of Patients With Neurofibromatosis Type IActive, not recruitingNCT009241961 country
- Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1CompletedNCT02211768Phase 11 country
- Agnostic Therapy in Rare Solid TumorsActive, not recruitingNCT06638931Phase 21 country
- EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT03618381Phase 11 country
- Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryCompletedNCT02180867Phase 2/33 countries
- Nivolumab and Ipilimumab in Treating Patients With Rare TumorsActive, not recruitingNCT02834013Phase 22 countries
- APX005M and Doxorubicin in Advanced SarcomaCompletedNCT03719430Phase 21 country
- Tazemetostat in Malignant Peripheral Nerve Sheath TumorsActive, not recruitingNCT04917042Phase 21 country
- SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath TumorsCompletedNCT03433183Phase 21 country
- B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT04483778Phase 11 country
- Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid TumorsTerminatedNCT05275478Phase 1/22 countries
- Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue SarcomaActive, not recruitingNCT04420975Phase 11 country
- Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1Active, not recruitingNCT056775941 country
- A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid TumorsActive, not recruitingNCT03611868Phase 1/22 countries
- Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young AdultsTerminatedNCT04530487Phase 21 country
- A Study of Different Dosing Schedules of Selinexor in Sarcoma PatientsCompletedNCT04811196Phase 11 country
- PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath TumorsTerminatedNCT02584647Phase 1/21 country
- Vaccine Therapy in Treating Patients with Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by SurgeryCompletedNCT02700230Phase 11 country
- A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I NeurofibromatosisTerminatedNCT05011019Phase 1/21 country
- Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue SarcomaCompletedNCT02584309Phase 21 country
- Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by SurgeryCompletedNCT03009201Phase 11 country
- Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue SarcomaCompletedNCT00053794Phase 21 country
- PET CT as Predictor of Response in Preoperative Chemotherapy for Soft Tissue SarcomaCompletedNCT00346125Not applicable1 country
- Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic SarcomaTerminatedNCT02601209Phase 1/21 country
- Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue SarcomaCompletedNCT00346164Phase 35 countries
- Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial SarcomaCompletedNCT02452554Phase 21 country
- Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue SarcomaCompletedNCT01532687Phase 21 country