M.D. Anderson Cancer Center: Sarcoma trials

The registry lists 48 Sarcoma studies with M.D. Anderson Cancer Center as lead sponsor. 9 are open to participants now and 9 have results posted.

Phase 1 20Phase 2 19Phase 3 1No phase 13(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility StudyRecruitingNCT07874828Phase 2
• A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue SarcomasRecruitingNCT07444619Phase 1
• Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue SarcomaRecruitingNCT07283731Phase 2
• SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue SarcomaRecruitingNCT07049848Phase 2
• T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.RecruitingNCT06474676Phase 1
• Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid TumorsRecruitingNCT04771520Phase 2
• Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME TrialRecruitingNCT04693377Not applicable
• Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent SarcomaRecruitingNCT04199026Not applicable
• Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy ProgramRecruitingNCT01772771
• Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer StudyTerminatedNCT05017103Phase 2Results posted
• Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma SubtypesCompletedNCT02815995Phase 2Results posted
• Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving ChemotherapyTerminatedNCT02732015Phase 2Results posted
• Phase I Dose Escalation of Monthly Intravenous Ra-223 Dichloride in OsteosarcomaCompletedNCT01833520Phase 1/2Results posted
• A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation TherapyCompletedNCT01624220Not applicableResults posted
• Fosaprepitant in Patients Receiving Ifosfamide-based RegimenCompletedNCT01490060Not applicableResults posted
• Dalteparin in Preventing DVT in Participants With CancerCompletedNCT00525057Not applicableResults posted
• Palonosetron in Sarcoma Patients Receiving Chemotherapy With Adriamycin and Ifosfamide (AI)CompletedNCT00410488Not applicableResults posted
• Evaluate PKs and Efficacy Assessment of Palifermin in Patients With SarcomaCompletedNCT00267046Phase 2Results posted
• Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient MalignanciesActive, not recruitingNCT06444880Phase 2
• A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or DeletionsActive, not recruitingNCT06308419Phase 1
• A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone SarcomaActive, not recruitingNCT05621668Phase 1
• Oncology Dashboard for the Improvement of Operational Efficiency and Patients Outcomes in Patients With SarcomaCompletedNCT05216029Not applicable
• Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid TumorsActive, not recruitingNCT05075993Phase 1
• Lurbinectedin With or Without Irinotecan in Treating Patients With Relapsed or High Risk Metastatic Ewing SarcomaWithdrawnNCT05042934Phase 1/2
• Identification of Surgical Management of Lymph Node Basins and Surgical Practice Patterns Among Sarcoma SurgeonsWithdrawnNCT04553744
• Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME StudyActive, not recruitingNCT04430725
• Modified T Cells, Chemotherapy, and Aldesleukin With or Without LV305 and CMB305 in Treating Participants With Advanced or Recurrent SarcomaCompletedNCT03450122Phase 1
• LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue SarcomasActive, not recruitingNCT03449108Phase 2
• Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid TumorsTerminatedNCT03420963Phase 1
• Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in ChildrenWithdrawnNCT03111069Phase 1
• Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal CordActive, not recruitingNCT02713269Phase 2
• Adoptive Therapy Using Antigen-Specific CD4 T-CellsWithdrawnNCT02210104Phase 1
• PP-Gemcitabine & External Beam Radiation-SarcomasCompletedNCT02046304Phase 1
• Aerosolized Aldesleukin in Treating Patients With Lung MetastasesActive, not recruitingNCT01590069Phase 1/2
• Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign DiseaseTerminatedNCT01552434Phase 1
• Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous BypassCompletedNCT01433302
• Caphosol in Sarcoma Patients With MucositisCompletedNCT00965172Phase 2
• Irinotecan (Camptosar) in Patients With Advanced SarcomasCompletedNCT00509860Phase 2
• Evaluation of a Novel CT-On-Rails or Trilogy Stereotactic Spine Radiotherapy System (SSRS)Active, not recruitingNCT00508443Phase 1/2
• Functional Outcomes Following Limb Sparing Surgery for Sarcoma PatientsWithdrawnNCT00508339
• Post-Operative Chemoradiation for Extremity & Trunk Soft Tissue SarcomaCompletedNCT00502411Phase 1
• Aerosol L9-NC and Temozolomide in Ewing's SarcomaCompletedNCT00492141Phase 1/2
• Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal CancerCompletedNCT00436657Phase 1
• Aranesp and Neulasta in Patients With Sarcoma Receiving Adriamycin and IfosfamideCompletedNCT00283621Not applicable
• Trial of Primary Prophylaxis With rhTPO Administered to Patients With High Risk Sarcoma Receiving Intensive ChemotherapyCompletedNCT00283582Phase 3
• Liposomal Vincristine for Pediatric and Adolescent Patients With Relapsed MalignanciesCompletedNCT00038207Phase 2
• Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue SarcomaCompletedNCT00004123Phase 1
• Doxorubicin Plus External-Beam Radiation Therapy in Treating Patients With Soft Tissue SarcomaCompletedNCT00004109Phase 1