Sarcoma, Synovial clinical trials
The registry lists 133 studies for Sarcoma, Synovial across more than 10 countries. 29 are recruiting or about to start. 25 of them are mainly about Sarcoma, Synovial (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
Get an email when these change. Save the Sarcoma, Synovial studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
European Organisation for Research and Treatment of Cancer - EORTC (14) · National Cancer Institute (NCI) (14) · Epizyme, Inc. (5) · USWM CT, LLC (5) · Fred Hutchinson Cancer Center (4) · M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · Takara Bio Inc. (2)
What is being tested here
Drugs under test in Sarcoma, Synovial studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open · Alkylating agents 1 open · Immune checkpoint inhibitors 4 · Angiogenesis inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors · University Health Network, Toronto
- Nov 2026Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 · M.D. Anderson Cancer Center
- Jan 2027Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma · Jonsson Comprehensive Cancer Center
- Apr 2027START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer · Valo Therapeutics Oy
- May 2027Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma · National Cancer Institute (NCI)
- Jun 2027Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision) · University Hospital Tuebingen
- Jun 2027Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas · Cellectar Biosciences, Inc.
- Oct 2027Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor · University Hospital Heidelberg
- Nov 2027Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers · National Cancer Institute (NCI)
Who these studies take
Of the 25 Sarcoma, Synovial studies recruiting now, 13 (52%) set no upper age limit and 9 (36%) stop at 75 or younger. 9 (36%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (28%) | 7 (28%) |
| 18 | 24 (96%) | 24 (96%) |
| 30 | 22 (88%) | 22 (88%) |
| 40 | 21 (84%) | 21 (84%) |
| 50 | 20 (80%) | 20 (80%) |
| 65 | 19 (76%) | 19 (76%) |
| 75 | 17 (68%) | 17 (68%) |
| 85 | 14 (56%) | 14 (56%) |
Across all 133 studies, recruiting or not: 25% stop at 75 or younger and 16% at 65; 46% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sarcoma, Synovial studies take
Of 18 phase 2 interventional studies under Sarcoma, Synovial, half reached primary completion within 45 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 45 mo30–80 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted1
Stopped1
Studies
Recruiting first, then most recently updated. Showing 50 of 133. Browse all 133 → or search them.
- START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of CancerRecruitingNCT05492682Phase 12 countries
- Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced SarcomaRecruitingNCT05711615Phase 11 country
- AOH1996 for the Treatment of Refractory Solid TumorsRecruitingNCT05227326Phase 11 country
- XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue SarcomaRecruitingNCT06571734Phase 21 country
- TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid TumorsRecruitingNCT07713732Phase 11 country
- Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial SarcomaRecruitingNCT07174427Phase 31 country
- Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare CancersNot yet recruitingNCT07686367Phase 2
- First-in-Human Trial of DS-2243a in Participants With Advanced Solid TumorsRecruitingNCT06644755Phase 15 countries
- A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid MalignanciesRecruitingNCT07613723Phase 11 country
- N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular TherapyRecruitingNCT07261657Early Phase 11 country
- Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-celAvailableNCT066175721 country
- SPEARHEAD-3 Pediatric StudyRecruitingNCT05642455Phase 1/21 country
- NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)RecruitingNCT06239272Phase 1/21 country
- Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1RecruitingNCT06083883Phase 11 country
- Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid TumorsRecruitingNCT06625190Phase 1/21 country
- Synovial Sarcoma Registry / Biospecimen RepositoryRecruitingNCT059103071 country
- Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).RecruitingNCT06607692Phase 1/21 country
- Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision)RecruitingNCT06094101Phase 1/21 country
- Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)RecruitingNCT03016819Phase 35 countries
- Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue SarcomaRecruitingNCT07169344Phase 21 country
- Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.RecruitingNCT07173972Phase 21 country
- HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced SarcomaRecruitingNCT04995003Phase 11 country
- ACTengine® IMA203 Combined With mRNA-4203RecruitingNCT06946225Phase 11 country
- Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic CancersRecruitingNCT05296564Phase 1/21 country
- MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue SarcomaRecruitingNCT06277154Phase 21 country
- Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced SarcomasRecruitingNCT07066982Phase 1/21 country
- Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell TumorRecruitingNCT06456359Phase 21 country
- EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial SarcomaNot yet recruitingNCT06748872Phase 11 country
- Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue SarcomaNot yet recruitingNCT06526897Not applicable
- Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell LiposarcomaActive, not recruitingNCT04044768Phase 25 countries
- A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical StudyTerminatedNCT02875548Phase 1/27 countries
- EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT03618381Phase 11 country
- Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and SarcomasActive, not recruitingNCT03478462Phase 13 countries
- Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid TumorsActive, not recruitingNCT03967223Phase 27 countries
- Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1Active, not recruitingNCT02650986Phase 1/21 country
- Tazemetostat Expanded Access Program for Adults With Solid TumorsNo longer availableNCT03874455
- Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryCompletedNCT02180867Phase 2/33 countries
- APX005M and Doxorubicin in Advanced SarcomaCompletedNCT03719430Phase 21 country
- MAGE-A4ᶜ¹º³²T for Multi-TumorActive, not recruitingNCT03132922Phase 12 countries
- B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT04483778Phase 11 country
- Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue SarcomaActive, not recruitingNCT04420975Phase 11 country
- Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma PatientsCompletedNCT04008238Not applicable1 country
- Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid TumorsActive, not recruitingNCT02869217Phase 11 country
- A Study of Tazemetostat in Adult Participants With Soft Tissue SarcomaCompletedNCT02601950Phase 29 countries
- Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma SubtypesCompletedNCT02815995Phase 21 country
- FHD-609 in Subjects With Advanced Synovial Sarcoma or Advanced SMARCB1-Loss TumorsTerminatedNCT04965753Phase 14 countries
- Effects of Itraconazole and Rifampin on the Blood Tazemetostat LevelsCompletedNCT04537715Phase 12 countries
- The Registry of Oncology Outcomes Associated with Testing and TreatmentCompletedNCT040284791 country
- A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null TumorsTerminatedNCT05355753Phase 11 country
- Study of TBI-1301 (NY-ESO-1 T Cell Receptor Gene Transduced Autologous T Lymphocytes) in Patients with Synovial SarcomaCompletedNCT03250325Phase 1/21 country