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Not yet recruitingNCT07164326Updated Sep 10, 2025

Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients

An interventional study of Dexmedetomidine and Saline in Pressor Response, sponsored by Assiut University. Not yet recruiting. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-09-10.

Sponsored by Assiut University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
Female
01

Study summary

Dexmedetomidine nebulization in sever preeclamptic patients

Read the detailed description

Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

02

Conditions studied

  • Pressor Response

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Keywords

  • Preeclampsia
  • Nebulization
03

In context

Pre-Eclampsia

883 studies on the registry are indexed under Pre-Eclampsia; 238 are open to participants now.

This study's planned enrollment of 100 is close to the median of 110 across 468 interventional studies indexed under Pre-Eclampsia.

Browse Pre-Eclampsia studies →

Lead sponsor

Assiut University is the lead sponsor of 4,916 studies on the registry; 2,113 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
  • ASA II, III

Exclusion criteria

Exclusion Criteria:

  • sever obesity (BMI ≥ 40)
  • Cardiac patients
  • History of diabetes mellitus
  • Renal dysfunction (elevated serum creatinine > 2mg\dl)
  • hepatic dysfunction (elevated hepatic enzyme three times above normal)
  • History to hypersensitivity to the tested drug.
  • Emergency surgery
  • Known fetal anomalies
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
100 participants (estimated)

Study arms

  • Experimental
    Dexmedetomidine

    Nebulization of dexmedetomidine

    Drug: Dexmedetomidine

  • Placebo comparator
    Saline

    Nebulization of saline

    Drug: Saline

Interventions

  • DrugDexmedetomidine

    Nebulization of dexmedetomidine

  • DrugSaline

    Nebulization of normal saline

06

What researchers measure

Primary outcomes

  1. Systolic blood pressure in response to endotracheal intubation

    the change in systolic blood pressure in response to endotracheal intubation

    Time frame: Intraoperative

Secondary outcomes

  1. Optic nerve sheath diameter

    the change in optic nerve sheath diameter in response to endotracheal intubation

    Time frame: Intraoperative

  2. Incidence of maternal postoperative sore throat

    Time frame: 1 hour Postoperative

  3. Incidence of maternal postoperative hoarseness of voice

    Time frame: 1 hour Postoperative

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 10, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07164326
Lead sponsor
Assiut University
Responsible party
Mohamed Sayed Hussein Hassan (Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial., Assiut University) — Principal investigator
First posted
Sep 10, 2025
Start date
Oct 15, 2025 (estimated)
Primary completion
Nov 15, 2026 (estimated)
Completion
Dec 15, 2026 (estimated)
Last update
Sep 10, 2025

Study contacts

Mohamed S. Hussein
Contact
mohamedmsh4274@gmail.com
+201028586836
Fatma Nabil
Contact
fatmanabil2012@aun.edu.eg

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.

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