An interventional study of Genicular nerve block via radiofrequency ablation in Knee Osteoarthritis (OA), Genicular Nerves Block and Radiofrequency Ablation, sponsored by Ankara City Hospital Bilkent. Completed at 1 site in Turkey (Türkiye). Open to participants aged 45 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Ankara City Hospital Bilkent · Not applicable, Interventional, and Treatment
Determination of the effect of ultrasound-guided pulsed radiofrequency applied to the genicular nerve on pain, balance, and proprioception in patients with chronic knee osteoarthritis
Surgical and non-surgical methods are used to treat knee osteoarthritis. Non-surgical treatments include patient education, self-management strategies, strengthening exercises, weight control, physical therapy, orthosis use, oral analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), steroids, hyaluronic acid, platelet-rich plasma (PRP) injections, prolotherapy, stem cell therapy, and genicular nerve blocks. All of these aim to reduce pain, improve function, and delay the need for surgery.
The genicular nerve block is a recently developed treatment option for knee osteoarthritis that targets three sensory nerves of the knee-the superior lateral, superior medial, and inferior medial genicular nerves-to block pain transmission to the central nervous system. Unlike alternatives such as intra-articular treatments and surgery, the block procedure is performed outside the knee joint. Genicular nerve blockade via radiofrequency ablation appears to be an emerging alternative for patients for whom conservative and surgical treatments have proven insufficient. Radiofrequency ablation of the genicular nerve provides temporary relief for symptomatic knee osteoarthritis, as it does not eliminate the potential for peripheral nerve regrowth and regeneration, and thus the recurrence of pain. Previous studies have also reported accidental falls in patients following genicular nerve radiofrequency ablation procedures. These findings have raised concerns that the genicular nerve radiofrequency ablation procedure may alter proprioception and impair balance. This study was conducted because there are a limited number of studies investigating the effects of genicular nerve block on pain and function in patients with chronic knee osteoarthritis.
3,391 studies on the registry are indexed under Osteoarthritis, Knee; 628 are open to participants now.
This study's enrollment of 28 is below the median of 69 across 2,808 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Ankara City Hospital Bilkent is the lead sponsor of 437 studies on the registry; 109 are open to participants now.
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Exclusion criteria:
Patients aged 45-80 years diagnosed with chronic knee osteoarthritis according to American College of Rheumatology criteria and presenting with Kellgren-Lawrence grade 2 or 3 radiological osteoarthritis
Other: Genicular nerve block via radiofrequency ablation
The aim is to determine the effects on pain, balance, and proprioception following ultrasound-guided pulsed genicular nerve radiofrequency ablation in patients with chronic knee osteoarthritis.
Also known as: Genicular nerve block, radiofrequency ablation
knee pain
Zero is equivalent to no pain, and 10 indicates the worst possible pain.
Time frame: first month and third month
balance
The HUR SmartBalance BTG4 system will be used to measure both static and dynamic postural balance. An increase in the equilibrium value in percentage terms will indicate an improvement.
Time frame: first and third month
proprioception
The Biodex System 3 (Biodex Medical Systems, Shirley, NY, USA) isokinetic dynamometer will be used to measure proprioception. Patients' proprioceptive sense will be assessed at 15 and 45 degrees. Indicating how closely the patient-with eyes closed-can perceive the 15-degree and 45-degree angles will demonstrate the change in proprioception.
Time frame: first and third month
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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