An interventional study of Rhythmic Auditory Stimulation with music and Rhythmic Auditory Stimulation with metronome in Knee Osteoarthritis, sponsored by Boston University Charles River Campus. Not yet recruiting. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Boston University Charles River Campus · Not applicable, Interventional, and Basic science
The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.
Participants with knee osteoarthritis (OA) will complete two study visits. Both visits will include three walking tasks, which are walking without music or metronome, walking to metronome, and walking with music. During the first visit, participants will alternate between three walking tasks and walk for 7 minutes, for a total of 3 trials. Participants muscle activity, brain activity, and movements will be recorded during these walking trials. During the second visit, participant will perform each walking task for 25 minutes, with rest in between. Participants muscle activity and movements will be recorded during these tasks. Participant's pressure pain threshold will be recorded at the beginning and after each task.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 20 is below the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Boston University Charles River Campus is the lead sponsor of 159 studies on the registry; 33 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 9 (64%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All participants will be exposed to different walking conditions including music, metronome, and no music or metronome
Behavioral: Rhythmic Auditory Stimulation with music · Behavioral: Rhythmic Auditory Stimulation with metronome · Behavioral: Control
Walking to Rhythmic Auditory Stimulation with music
Walking to Rhythmic Auditory Stimulation with metronome
Walking to no music or metronome
Exercise-Induced Hypoalgesia (EIH)
Change in pressure pain threshold (PPT) from baseline to after each walking task
Time frame: Baseline
Medial quadriceps - medial hamstrings muscle coactivation
Medial quadriceps-medial hamstrings muscle co-activation in each walking task will be assessed using surface electromyography
Time frame: Baseline
Medial quadriceps- medial gastrocnemius muscle coactivation
Medial quadriceps-medial gastrocnemius muscle co-activation in each walking task will be assessed using surface electromyography
Time frame: Baseline
Lateral quadriceps- lateral hamstrings muscle coactivation
Lateral quadriceps-lateral hamstrings muscle co-activation in each walking task will be assessed using surface electromyography
Time frame: Baseline
Lateral quadriceps - lateral gastrocnemius muscle coactivation
Lateral quadriceps-lateral gastrocnemoius muscle co-activation in each walking task will be assessed using surface electromyography
Time frame: Baseline
Prefrontal cortex activation
Prefrontal cortex (PFC) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS)
Time frame: Baseline
Supplementary Motor Area activation
Supplementary Motor Area (SMA) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS)
Time frame: Baseline
Auditory-motor synchronization
Difference between actual cadence and target cadence in each walking ask (except walking to no music or metronome)
Time frame: Baseline
Physical activity enjoyment
Modified Physical Activity Enjoyment Scale (PACES) score after each walking task. Range is 7-49 with higher scores indicating greater enjoyment.
Time frame: Baseline
No study locations are listed for this record.
Plan to share: Yes — Requests will be considered on an individual basis
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for May 2027, 6 months later.
Of 1,111 non-industry interventional studies with no phase under Osteoarthritis, Knee, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 36. This study's planned 6 months is below that.
Counting every sponsor, half of 1,251 studies reached it within 18 months; a quarter within 8 and three quarters within 36.
Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 26, 2026: primary completion Jun 2027 → May 2027 and completion Jul 2027 → Jun 2027.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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