An interventional study of heat application in Knee Osteoarthritis (Knee OA), sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Ain Shams University · Not applicable, Interventional, and Supportive care
Among 91 studies in Osteoarthritis, Knee with a site in Egypt — 28 open to participants now, 34 under way, 1 of them phase 3. Osteoarthritis, Knee · Egypt.
Among the 91 studies in Osteoarthritis, Knee with a site in Egypt, this one is the 10th largest by enrollment of the 83 interventional ones, is one of 17 that started in 2024, is one of 76 with no phase, and was the 91st registered.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's enrollment of 100 is above the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →28 of the 91 studies in Osteoarthritis, Knee with a site in Egypt are open now, in 1 country. Each count lists the studies.
Of the 382 Osteoarthritis, Knee studies recruiting now, 176 (46%) set no upper age limit and 113 (30%) stop at 75 or younger; 19 take children under 18; 39 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →91 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 17 started in 2024.
Median enrollment 62 across the 83 interventional studies, 69 across the 8 observational. Of the 50 that completed or were terminated, 0 (0%) have results posted.
None of the 91 has an industry lead sponsor. The 10 most frequent:
Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Ain Shams University has 7 studies filed under Osteoarthritis, Knee — fewer than ten, so there is no comparison to draw.
12 of the studies in Osteoarthritis, Knee with a site in Egypt that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07047040Phase 3Assiut UniversityAnalgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin | 2027-10-30 |
| NCT07664371Tanta UniversityCryoneurolysis Versus Radiofrequency in Knee Osteoarthritis | 2026-11 |
| NCT07774195Cairo UniversityEfficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis | 2026-11-21 |
| NCT07468734German International UniversityShock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis | 2026-11-30 |
| NCT07666347Tanta UniversityIntraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis | 2026-12-01 |
Among the 91 studies in Osteoarthritis, Knee with a site in Egypt, from their registry updates:
The purpose of this clinical study is to evaluate the effectiveness of local heat application in relieving joint symptoms and improving physical mobility among patients diagnosed with knee osteoarthritis.
Participants will be allocated into two groups: an intervention group receiving local heat applications according to a structured protocol, and a control group receiving standard care or routine management.
The primary objective is to determine whether local heat therapy leads to a statistically significant reduction in musculoskeletal knee pain and stiffness, as well as an improvement in overall physical function. Outcome parameters will be evaluated at baseline and following the treatment period using validated clinical assessment tools.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The intervention group received 20-minute heat application twice a day (morning and evening) for 6 weeks in addition to the routine medical care
Other: heat application
control group received routine medical care only
20-minute heat application twice a day (morning and evening) for 6 weeks in addition to the routine medical care.
Change in Musculoskeletal Knee Pain, Stiffness and Physical Function for Patients with Knee Osteoarthritis
Assessed using the WOMAC. Higher scores indicate greater pain severity.
Time frame: Outcomes were assessed at baseline and at weeks 2, 4, and 6
Plan to share: No
No publications or documents are linked to this record.
Ran from Dec 2024 to primary completion in May 2025, 5 months.
Of 1,111 non-industry interventional studies with no phase under Osteoarthritis, Knee, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 36. This study's 5 months is below that.
Counting every sponsor, half of 1,251 studies reached it within 18 months; a quarter within 8 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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