Keratoconus clinical trials
The registry lists 307 studies for Keratoconus across more than 10 countries. 56 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 142
- Status unknown
- 62
- Recruiting
- 36
- Terminated
- 23
- Active, not recruiting
- 17
- Not yet recruiting
- 14
Phase
- Phase 3
- 44
- Phase 2
- 40
- Phase 1
- 14
- Phase 4
- 9
- Early Phase 1
- 3
Where
- United States
- 91
- Egypt
- 28
- France
- 24
- China
- 13
- United Kingdom
- 12
- Iran, Islamic Republic of
- 11
Who runs them
Cornea and Laser Eye Institute (10) · Assiut University (9) · Glaukos Corporation (9) · Democritus University of Thrace (8) · Shahid Beheshti University of Medical Sciences (6) · Cxlusa (6) · Oregon Health and Science University (6) · Instituto de Oftalmología Fundación Conde de Valenciana (5)
Studies
Recruiting first, then most recently updated. Showing 50 of 307 — search for more.
- Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal EctasiaRecruitingNCT07841470Phase 2/31 country
- Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal CrosslinkingEnrolling by invitationNCT06235567Phase 1/21 country
- A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and DiseasesRecruitingNCT077808901 country
- UNITY DX Cornea StudyNot yet recruitingNCT077687351 country
- Corneal Lenticule Implantation in Keratoconus Disease With Relex Smile SurgeryEnrolling by invitationNCT04591587Not applicable1 country
- Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and KeratoconusNot yet recruitingNCT07559188Not applicable2 countries
- Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for KeratoconusRecruitingNCT07629557Phase 41 country
- Corneal Elastography and Patient Specific ModelingRecruitingNCT030307551 country
- Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CTNot yet recruitingNCT07599020Not applicable
- Clinical and Subclinical Keratoconus Cohort StudyNot yet recruitingNCT075538321 country
- The Homburg Keratoconus Center (HKC)RecruitingNCT039231011 country
- Outcomes of CTAK SurgeryNot yet recruitingNCT07474870Phase 41 country
- Intacs Prescription Inserts for Keratoconus PatientsRecruitingNCT02138669Not applicable1 country
- A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus PatientsNot yet recruitingNCT04584125Not applicable1 country
- Artificial Intelligence-assisted Diagnosis in OphthalmologyNot yet recruitingNCT074978151 country
- Corneal Biomechanical Analysis Using Brillouin MicroscopyEnrolling by invitationNCT045989321 country
- Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With KeratoconusRecruitingNCT07400952Phase 21 country
- Study of TN-001 Topical Eyedrops for KeratoconusEnrolling by invitationNCT07388069Phase 1/21 country
- Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal DiseasesRecruitingNCT07124910Phase 31 country
- Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down SyndromeRecruitingNCT07135167Phase 31 country
- PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in KeratoconusRecruitingNCT07372911Not applicable1 country
- First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of KeratoconusRecruitingNCT06451718Not applicable2 countries
- Investigator Initiated, Prospective Study of Xenia Corneal LenticuleRecruitingNCT04741230Not applicable1 country
- fMRI and IVCM Cornea Microscopy of CXL in KeratoconusRecruitingNCT044395521 country
- High Resolution, High-speed Multimodal Ophthalmic ImagingRecruitingNCT04129021Not applicable1 country
- A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal EctasiaRecruitingNCT021189221 country
- Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal EctasiaRecruitingNCT04094090Phase 21 country
- AI-Orchestrated Workflow Versus Consultant Ophthalmologist for Refractive Surgery and Keratoconus Diagnosis (AEYE Trial)Enrolling by invitationNCT070962321 country
- Scleral Lens Fitting Using Wide-Field OCTRecruitingNCT045700201 country
- OCT in Diagnosis of Irregular CorneasRecruitingNCT035048001 country
- Collagen Cross-linking in KeratoconusRecruitingNCT03760432Not applicable1 country
- Risk Factors and Progression of KeratoconusRecruitingNCT05676580Not applicable1 country
- Effect of Corneal and Scleral RGP Lenses on Ocular Health and Visual Quality in KeratoconusRecruitingNCT06921967Not applicable1 country
- The K-Map Study, Global Prevalence of KCRecruitingNCT0311571012 countries
- Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive KeratoconusRecruitingNCT06450470Phase 31 country
- Evaluation of Corneal Epithelial Mapping in Diagnosis of Early Keratoconus by Anterior Segment Optical Coherence TomographyNot yet recruitingNCT06914973
- Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With KeratoconusRecruitingNCT06601101Phase 31 country
- Enhancing Scleral Lens Fit With Advanced ImagingEnrolling by invitationNCT067516151 country
- Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug ImagingNot yet recruitingNCT067390181 country
- The Collagen Factors of Rapid Progression of Keratoconus in Children.RecruitingNCT067229371 country
- Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-LinkingRecruitingNCT03918408Phase 11 country
- Clinical Investigation for a Multifunction Ophthalmic Measurement DeviceRecruitingNCT06565091Not applicable1 country
- Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus ManagementNot yet recruitingNCT06549387Not applicable1 country
- Safety and Efficacy of Corneal Cross-linking in Subjects With KeratoconusRecruitingNCT05314738Phase 1/21 country
- Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea ThinningRecruitingNCT05516004Phase 21 country
- INTACS (Intrastromal Corneal Ring Segments) For Corneal EctasiaNot yet recruitingNCT02512432Not applicable
- Assessing Patient Engagement in Keratoconus Clinical ResearchNot yet recruitingNCT062887371 country
- Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Randomized Trial (SHARK)RecruitingNCT06264024Not applicable1 country
- Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin KeratoconusRecruitingNCT06159881Not applicable1 country
- Evolution of a Novel Optical Coherence Tomography Based Index in Diagnosing KeratoconusRecruitingNCT061524841 country