Keratoconus clinical trials

The registry lists 313 studies for Keratoconus across more than 10 countries. 56 are recruiting or about to start. 287 of them are mainly about Keratoconus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.

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Status

Completed: 144
Status unknown: 65
Recruiting: 37
Terminated: 24
Active, not recruiting: 16
Not yet recruiting: 12

Phase

Phase 3: 45
Phase 2: 41
Phase 1: 14
Phase 4: 8
Early Phase 1: 3

Where

United States: 94
Egypt: 26
France: 24
United Kingdom: 13
China: 12
Brazil: 12

Who runs them

Assiut University (11) · Cornea and Laser Eye Institute (10) · Glaukos Corporation (9) · Democritus University of Thrace (8) · Oregon Health and Science University (6) · Shahid Beheshti University of Medical Sciences (6) · Medical University of Vienna (5) · Federal University of São Paulo (5)

What is being tested here

Drugs under test in Keratoconus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Riboflavin	5	16	22
Dexamethasone	2	0	5
Dexamethasone phosphate	1	0	1
Platelet rich plasma	1	0	1
Dextrans	0	1	1
Botulinum toxin type A	0	0	1
Insulin	0	1	1

Drug classes tested here Corticosteroids 2 open

Coming up

11phase 3 studies under way

20studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Apr 2027Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial · Phase 3 · Sahlgrenska University Hospital
Nov 2026UNITY DX Cornea Study · Alcon Research
Dec 2026Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking · Maanasa Indaram, MD
Dec 2026Treating Corneal Thinning Conditions With CCL Vario Riboflavin (CXL) · Kent Wellish MD
Dec 2026Collagen Cross-linking in Keratoconus · Oregon Health and Science University
Dec 2026Investigator Initiated, Prospective Study of Xenia Corneal Lenticule · The Royal Wolverhampton Hospitals NHS Trust
Dec 2026Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT · Tanta University
Dec 2026Study of TN-001 Topical Eyedrops for Keratoconus · TheiaNova Ltd.
Feb 2027First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus · Recornea Srl
Mar 2027Performance Evaluation of the OCUTOP Hand-held Corneal Topographer · University of Plymouth

Who these studies take

Of the 37 Keratoconus studies recruiting now, 21 (57%) set no upper age limit and 11 (30%) stop at 75 or younger. 17 (46%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 15 (41%) take healthy volunteers.

Recruiting studies that take each age, of 37
Age	Women	Men
10	11 (30%)	11 (30%)
18	34 (92%)	34 (92%)
30	36 (97%)	36 (97%)
40	35 (95%)	35 (95%)
50	32 (86%)	32 (86%)
65	29 (78%)	29 (78%)
75	27 (73%)	27 (73%)
85	23 (62%)	23 (62%)

Across all 313 studies, recruiting or not: 37% stop at 75 or younger and 33% at 65; 39% take children; 1% are for women only and 0% for men only; 28% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Keratoconus studies take

Of 68 interventional studies with no phase under Keratoconus, half reached primary completion within 34 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	34 mo12–59 · 68 studies	—	34 mo12–54 · 59 studies
Observational	30 mo13–95 · 36 studies	—	23 mo13–204 · 33 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 313. Browse all 313 → or search them.