An observational study in Keratoconus, sponsored by University Hospital, Geneva. Recruiting at 12 sites in 12 countries. Open to participants aged 6 Years to 23 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-11.
Sponsored by University Hospital, Geneva · Observational
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss.
The overall goal of this study is to assess the prevalence of keratoconus (KC) in children and adolescents in various regions of the world based on modern tomographic imaging methods, and to verify whether the occurrence rates reported from literature should be corrected. Our hypothesis is that the prevalence of the disease is much higher than that traditionally reported.
At each site, corneal tomography examinations (Pentacam) will be performed bilaterally in children and adolescents, who are not ill or with any ophthalmological symptom. The population to be studied will be composed of children and adolescents on medical visits for non-ophthalmologic reasons, aged between 6 and 20 years. Multiple cities, from different continents (North America, South America, Asia and Europe) will participate.
313 studies on the registry are indexed under Keratoconus; 56 are open to participants now.
This study's planned enrollment of 20,000 is above the median of 130 across 97 observational studies indexed under Keratoconus.
Browse Keratoconus studies →University Hospital, Geneva is the lead sponsor of 379 studies on the registry; 70 are open to participants now.
Counted across the registry records on this site, refreshed daily.
This project will include children and adolescent age (6 - 23).The rationale for selecting this age range is to detect the disease KC at early stages.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
One visit to Ophthalmology Department is required from participant. Parents or legal guardians must attend with their child. The interview and test during visit take approximately 15 minutes. Interview includes filling out a questionnaire about risk factors of the disease and double check on understanding the consent form. The child will sit in front of the instrument (Pentacam HR Scheimpflug imaging system). The rotational measuring procedure generates Scheimpflug images in three dimensions. The images taken during the examination are digitalized, and all image data are transferred to the computer. It calculates a 3D virtual model of the anterior eye segment, from which all additional information is derived.
Prevalence of keratoconus
Number of keratoconus cases detected
Time frame: 15 minutes
Not enrolling at this site.
Not enrolling at this site.
Started Dec 2015 (actual). Primary completion is estimated for Feb 2030, 169 months after the start.
Of 33 non-industry observational studies under Keratoconus, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 204. This study's planned 169 months is above that.
Counting every sponsor, half of 36 studies reached it within 30 months; a quarter within 13 and three quarters within 95.
How these figures are worked out, and which studies are left out of them.
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