An observational study in Keratoconus, sponsored by Universität des Saarlandes. Recruiting at 1 site in Germany. Per ClinicalTrials.gov, last updated 2026-04-27.
Sponsored by Universität des Saarlandes · Observational
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
The Homburg Keratoconus Center (HKC) was founded in 2010 and, up to now, comprises more than 3,000 Keratoconus patients. Topographic, tomographic and biomechanic characteristics of the disease are being analyzed with the intention to elucidate how the disease begins and develops during lifetime.
313 studies on the registry are indexed under Keratoconus; 56 are open to participants now.
This study's planned enrollment of 5,000 is above the median of 130 across 97 observational studies indexed under Keratoconus.
Browse Keratoconus studies →Universität des Saarlandes is the lead sponsor of 68 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Keratoconus patients of all ages presenting in the department of ophthalmology, Saarland University Medical Center, Homburg, Saarland, Germany, should be included.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Aim is to include as many Keratoconus patients as possible with the intention to elucidate how the disease begins and develops during lifetime.
Diagnostic Test: Topographic, tomographic and biomechanical analysis.
The study is based upon data obtained during routine medical follow-ups using 1. the Pentacam high resolution (Oculus, Wetzlar, Germany) 2. the Corvis ST (Oculus, Wetzlar, Germany) 3. the Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2 (Tomey, Nagoya, Japan) 4. the Ocular Response Analyzer (Reichert Technologies, New York, USA).
An overview about development of anterior corneal curvature in Keratoconus disease during lifetime.
The anterior radius of curvature (ARC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Time frame: 01/01/2011-01/01/2019
An overview about development of posterior corneal curvature in Keratoconus disease during lifetime.
The posterior radius of curvature (PRC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Time frame: 01/01/2011-01/01/2019
An overview about development of the thinnest corneal pachymetry in Keratoconus disease during lifetime.
The thinnest corneal pachymetry of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Time frame: 01/01/2011-01/01/2019
An overview about development of the best corrected distance visual acuity in Keratoconus disease during lifetime.
The best corrected distance visual acuity of Keratoconus patients as raised as part of the clinical examination at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Time frame: 01/01/2011-01/01/2019
Reproducibility study: Kmax.
Measurements of Kmax measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.
Time frame: 01/01/2011-01/01/2019
Reproducibility study: Thinnest corneal pachymetry.
Measurements of the thinnest corneal pachymetry as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.
Time frame: 01/01/2011-01/01/2019
Reproducibility study: Thinnest corneal pachymetry at the apex position.
Measurements of the thinnest corneal pachymetry at the apex position as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.
Time frame: 01/01/2011-01/01/2019
Plan to share: No
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Universität des Saarlandes