Hypoxia-Ischemia, Brain clinical trials

The registry lists 261 studies for Hypoxia-Ischemia, Brain across more than 10 countries. 94 are recruiting or about to start. 178 of them are mainly about Hypoxia-Ischemia, Brain (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed: 105
Recruiting: 60
Status unknown: 28
Not yet recruiting: 27
Active, not recruiting: 13
Withdrawn: 12

Phase

Phase 2: 37
Phase 1: 35
Phase 3: 17
Early Phase 1: 9
Phase 4: 3

Where

United States: 84
Canada: 19
China: 18
United Kingdom: 16
Turkey: 15
France: 13

Who runs them

Assiut University (7) · University of California, San Francisco (5) · Semmelweis University (5) · Assistance Publique - Hôpitaux de Paris (5) · University of Florida (5) · Boston Children's Hospital (5) · University of Wisconsin, Madison (4) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4)

What is being tested here

Drugs under test in Hypoxia-Ischemia, Brain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Sildenafil	2	0	3
Human milk	2	0	2
Allopurinol	2	2	2
Melatonin	1	0	4
Caffeine	1	1	3
Dexmedetomidine	1	0	3
Levetiracetam	1	0	3
Hydrocortisone	1	1	2
Metformin	1	0	2
Cytidine Diphosphate Choline	1	1	2

Drug classes tested here Stimulants 1 open

Coming up

7phase 3 studies under way

39studies finish main data collection within a year2 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Dec 2026A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia · Phase 3 · ReAlta Life Sciences, Inc.
Dec 2026COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE · Phase 3 · University of Child Health Sciences and Children's Hospital, Lahore
Nov 2026Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy · Pharmazz, Inc.
Dec 2026Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy · Khyber Girls Medical College
Dec 2026Multiomics Profiling of CSF in Cardiac Arrest Survivors · Chungnam National University Hospital
Dec 2026Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit · Shirley Ryan AbilityLab
Dec 2026Is Feeding During Therapeutic Hypothermia Safe and Can Improve Outcomes in Infants With Hypoxic-ischaemic Encephalopathy · Nutricia Foundation
Jan 2027Optimization of Routine Obstetric and Neonatal Care in the Management of Severe Perinatal Asphyxia in Term or Near-term Newborns: Analysis of Sub-optimal Care · Assistance Publique - Hôpitaux de Paris
Jan 2027Neonate Cerebral Activity in Immediate Post Partum · Centre Hospitalier Universitaire, Amiens
Jan 2027Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS) · MaineHealth

Who these studies take

Of the 60 Hypoxia-Ischemia, Brain studies recruiting now, 21 (35%) set no upper age limit and 37 (62%) stop at 75 or younger. 46 (77%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 7 (12%) take healthy volunteers.

Recruiting studies that take each age, of 60
Age	Women	Men
10	13 (22%)	13 (22%)
18	26 (43%)	25 (42%)
30	24 (40%)	23 (38%)
40	24 (40%)	23 (38%)
50	24 (40%)	23 (38%)
65	24 (40%)	23 (38%)
75	24 (40%)	23 (38%)
85	23 (38%)	22 (37%)

Across all 261 studies, recruiting or not: 72% stop at 75 or younger and 70% at 65; 80% take children; 2% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Hypoxia-Ischemia, Brain studies take

Of 50 observational studies under Hypoxia-Ischemia, Brain, half reached primary completion within 43 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	33 mo19–63 · 47 studies	—	33 mo19–63 · 46 studies
Observational	43 mo20–… · 50 studies	—	43 mo20–… · 46 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 261. Browse all 261 → or search them.