A Phase 3 interventional study of MgSO4 (seizure prevention) and Melatonin , Mgso4 in HIE - Hypoxic - Ischemic Encephalopathy, sponsored by University of Child Health Sciences and Children's Hospital, Lahore. Not yet recruiting. Open to participants aged 1 Hour to 28 Days. Per ClinicalTrials.gov, last updated 2026-06-17.
Sponsored by University of Child Health Sciences and Children's Hospital, Lahore · Phase 3, Interventional, and Treatment
COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHALOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE Participants of group A will have 3 doses of MgSO4 infusion at rate of 250mg/kg per day intravenous over 1hour on day 0,1,2 Participants of group B will have 5 doses of Melatonin 10mg/kg for 5days along with MgSO4. They will undergo reassessment of arterial PH and serum LDH after completion of therapy. They will be followed for length of hospital stay and time until feed is initiated.
261 studies on the registry are indexed under Hypoxia-Ischemia, Brain; 94 are open to participants now.
This study's planned enrollment of 80 is above the median of 50 across 156 interventional studies indexed under Hypoxia-Ischemia, Brain.
Browse Hypoxia-Ischemia, Brain studies →University of Child Health Sciences and Children's Hospital, Lahore is the lead sponsor of 11 studies on the registry; 4 are open to participants now.
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five doses of melatonin (10mg/kg daily enteral for 5days) along with Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2
Drug: Melatonin , Mgso4
Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2
Drug: MgSO4 (seizure prevention)
Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2
Drug pages: Melatonin · Magnesium sulfate anhydrous
Five doses of melatonin along with three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2
1.Change in PH 2.Serum LDH(U/L)
change in arterial PH,SERUM LDH
Time frame: 5 DAYS
No study locations are listed for this record.
Plan to share: No — I do not plan to share raw participant data
No publications or documents are linked to this record.
Start is estimated for Jul 2026; primary completion for Dec 2026, 5 months later.
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This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Melatonin · Magnesium sulfate anhydrous
University of Child Health Sciences and Children's Hospital, Lahore