Neurologic Manifestations clinical trials
The registry lists 425 studies for Neurologic Manifestations across more than 10 countries. 82 are recruiting or about to start. 77 of them are mainly about Neurologic Manifestations (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 200 narrower conditions too, such as Pain: 48,535 studies, 10,132 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Center for Research Resources (NCRR) (28) · National Institute of Neurological Disorders and Stroke (NINDS) (17) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (8) · H. Lee Moffitt Cancer Center and Research Institute (7) · Vanderbilt University Medical Center (6) · Stanford University (6) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Medical University of South Carolina (5)
What is being tested here
Drugs under test in Neurologic Manifestations studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Islet Amyloid Polypeptide | 2 | 0 | 2 |
| Sepofarsen | 1 | 3 | 4 |
| Dexmedetomidine | 1 | 0 | 2 |
| Disulfiram | 1 | 0 | 1 |
| CHT101 | 1 | 0 | 1 |
| MT027 | 1 | 0 | 1 |
| Nicotinamide-beta-riboside | 1 | 0 | 1 |
| Autologous Anti-B7-H3 CAR T Cells | 1 | 0 | 1 |
| Sugammadex | 1 | 0 | 1 |
| Neostigmine | 1 | 0 | 1 |
Drug classes tested here Alkylating agents 6 · Tyrosine kinase inhibitors (TKIs) 3 · Dopamine agonists 3 · Antipsychotics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2027Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION) · Phase 3 · Laboratoires Thea
- Dec 2026Modafinil and Cognitive Function in POTS · Vanderbilt University Medical Center
- Dec 2026Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery · ARNAS Civico Di Cristina Benfratelli Hospital
- Dec 2026Handheld Point of Care Electro-Diagnostic Device · Indiana University
- Dec 2026Developing Effectiveness Evaluation and Therapeutic Programs of Rehabilitation · National Research Center for Rehabilitation Technical Aids
- Dec 2026Accelerated High-Dose tDCS for Depression · Medical University of South Carolina
- Jan 2027Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants · Sunnybrook Health Sciences Centre
- Jan 2027Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery · Alexander T. Yahanda
- Jan 2027The "What Is Important to Us" Communication Intervention Pilot Clinical Trial · Seattle Children's Hospital
- Feb 2027B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme · Stanford University
Who these studies take
Of the 59 Neurologic Manifestations studies recruiting now, 31 (53%) set no upper age limit and 14 (24%) stop at 75 or younger. 15 (25%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 13 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 13 (22%) | 12 (20%) |
| 18 | 48 (81%) | 47 (80%) |
| 30 | 53 (90%) | 52 (88%) |
| 40 | 52 (88%) | 51 (86%) |
| 50 | 50 (85%) | 50 (85%) |
| 65 | 50 (85%) | 50 (85%) |
| 75 | 48 (81%) | 48 (81%) |
| 85 | 36 (61%) | 36 (61%) |
Across all 425 studies, recruiting or not: 39% stop at 75 or younger and 30% at 65; 32% take children; 3% are for women only and 3% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Neurologic Manifestations studies take
Of 71 interventional studies with no phase under Neurologic Manifestations, half reached primary completion within 39 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 39 mo12–67 · 71 studies | — | 41 mo17–80 · 63 studies |
| Observational | 39 mo22–339 · 59 studies | — | 40 mo26–339 · 52 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Stopped1
- Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High Grade GliomaSuspendedOct 22, 2026NCT07719127
Newly registered1
- Closed-Loop SCS-BCI for Post-Stroke HemiplegiaOct 29, 2026NCT07903116
Studies
Recruiting first, then most recently updated. Showing 50 of 425. Browse all 425 → or search them.
- Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery LesionsRecruitingNCT07258290Not applicable4 countries
- CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)RecruitingNCT044903171 country
- rTMS for Postoperative Brain Tumor PatientsRecruitingNCT07530536Not applicable1 country
- Closed-Loop SCS-BCI for Post-Stroke HemiplegiaNot yet recruitingNCT07903116Not applicable1 country
- Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High Grade GliomaNot yet recruitingNCT07719127Phase 11 country
- Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)RecruitingNCT06891443Phase 310 countries
- Optic Nerve Sheath Diameter, Carotid Duplex and Transcranial Duplex as a Prognostic FactorRecruitingNCT045103631 country
- Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord InjuryRecruitingNCT06330181Not applicable1 country
- Improving Measurement and Treatment of Post-stroke NeglectRecruitingNCT03317860Not applicable1 country
- Early Neurological Outcome in Pediatric EncephalitisNot yet recruitingNCT07830927
- Pharmacoscopy for Patients With Refractory Primary Brain TumorsRecruitingNCT06804655Phase 21 country
- B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma MultiformeRecruitingNCT05474378Phase 11 country
- Wearable-Triggered Digital Safety Net for Real-Time Monitoring & Intervention in Leptomeningeal MetastasisNot yet recruitingNCT07704034Not applicable1 country
- Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History StudyRecruitingNCT0601694617 countries
- Exploration of the Utility of Dental-dedicated MRI for DentistryRecruitingNCT069481621 country
- Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in HypotoniaRecruitingNCT05527652Not applicable1 country
- Trans-Auricular Stimulation for Postoperative Inflammation in Spine SurgeryRecruitingNCT07218133Not applicable1 country
- Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor SurgeryRecruitingNCT077178271 country
- Personality Traits as a Variable in the Recovery of Patients With Acquired Brain InjuryRecruitingNCT071198271 country
- Rett Syndrome RegistryRecruitingNCT054323491 country
- Immediate Effects of External Trigeminal Nerve Stimulation on Motor Dysfunction in Parkinson's DiseaseNot yet recruitingNCT07656129Not applicable1 country
- Neurosciences Research RepositoryRecruitingNCT008579221 country
- Stimulation-Based Modulation of Spinal and Cortical Sensory PathwaysRecruitingNCT07401186Not applicable1 country
- Pharmacological Reversal of Neuromuscular Blockade in Critically Ill PatientsRecruitingNCT05993390Not applicable1 country
- PIRe 2.0: A Stepped-Care Model for Involving Relatives Across SectorsNot yet recruitingNCT07590726Not applicable1 country
- Non-invasive BCI-controlled Assistive DevicesRecruitingNCT05183152Not applicable1 country
- MRinRT: Swansea University and SWWCC Collaboration Study.Not yet recruitingNCT073651241 country
- ViBandz Feasibility StudyRecruitingNCT074585681 country
- NeuroVision vs Standard NeuromonitoringRecruitingNCT04639297Not applicable1 country
- MEP Up-conditioning to Target Corticospinal PlasticityRecruitingNCT06989905Early Phase 11 country
- A Phase I, Single-arm, Open-label Clinical Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of CHT101 Cell Infusion in Adult Subjects With Recurrent or Progressive Malignant Primary Brain Tumors(CROWN)Not yet recruitingNCT07496073Phase 1
- Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)RecruitingNCT058596591 country
- Auricular Stimulation for Functional Dyspepsia With Insomnia: Efficacy and MechanismsRecruitingNCT07442734Not applicable1 country
- Collection of Demographic, Clinical, and Instrumental Data of Patients With Peripheral Neuropathy Including Neurological Examination Data, Peripheral Nerve Conduction Analysis, and Nerve Electromyography and Ultrasound).RecruitingNCT074379891 country
- Repurposing Mirtazapine in Rett SyndromeRecruitingNCT07430046Phase 21 country
- The "What Is Important to Us" Communication Intervention Pilot Clinical TrialRecruitingNCT06208332Phase 21 country
- Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar MicrodiskectomyRecruitingNCT074133021 country
- Handheld Point of Care Electro-Diagnostic DeviceRecruitingNCT07223827Not applicable1 country
- Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management VisitsRecruitingNCT06387290Phase 31 country
- Hypersensitivity to Amylin in Post-Traumatic HeadacheNot yet recruitingNCT07340775Not applicable1 country
- Amylin-Induced Migraine Attacks Without AuraNot yet recruitingNCT07340788Not applicable1 country
- Menthol for Improving Movement and Sleep in Parkinson's Disease PatientsNot yet recruitingNCT07294469Phase 21 country
- TMS-related Measures as Biomarker of Cognitive Impairment in PDRecruitingNCT06835595Not applicable1 country
- Personalized Treatment by rTMS in Chronic Pain - Study2RecruitingNCT07247552Not applicable1 country
- Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery PatientsRecruitingNCT04289142Phase 41 country
- Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA CenterRecruitingNCT072058611 country
- Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist TreatmentRecruitingNCT067267851 country
- Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / MetastasesRecruitingNCT07162246Phase 21 country
- Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After VentilotherapyRecruitingNCT063129561 country
- A Vision-Language Foundation Model for Brain Disease Diagnosis From Multimodal DataRecruitingNCT071268211 country