An observational study in Postoperative Hyperalgesia, sponsored by The Second Affiliated Hospital of Chongqing Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2022-12-28.
Sponsored by The Second Affiliated Hospital of Chongqing Medical University · Observational
To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.
166 studies on the registry are indexed under Hyperalgesia; 14 are open to participants now.
This study's enrollment of 60 is below the median of 87 across 18 observational studies indexed under Hyperalgesia.
Browse Hyperalgesia studies →The Second Affiliated Hospital of Chongqing Medical University is the lead sponsor of 102 studies on the registry; 32 are open to participants now.
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Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were included.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Surgery performed during 08:00 to 12:00
Drug: Remifentanil
Surgery performed during 14:00 to 18:00
Drug: Remifentanil
Remifentanil was used for maintenance of anesthesia.
Postoperative hyperalgesia when discharged from postanesthesia care unit
The ratio of pressure pain threshold when discharged from PACU compare to before surgery
Time frame: from the 30 minutes before the surgery until to the time when discharged from postanesthesia care unit, assessed up to about 2 hours
Postoperative hyperalgesia at 24 hours after surgery
The ratio of pressure pain threshold at 24 hours after surgery compare to before surgery
Time frame: from the 30 minutes before the surgery until to 24 hours after surgery
Postoperative pain intensity
Pain intensity was assessed by numerical rating scale (0-10, 0 represents painless; 10 represents intolerable pain)
Time frame: from the time when the surgery was completed until to 24 hours after surgery
Postoperative analgesic requirements
Analgesic requirements was assessed by recording the volume of patient controlled analgesia pump
Time frame: from the time when the surgery was completed until to 24 hours after surgery
Plasma concentration of remifentanil and sufentanil
Determined by Elisa test
Time frame: from 30 minutes before the surgery until to the time after stop infusion of remifentanil, assessed up to about 2 hours
Activity of plasma nonspecific esterase
Determined by laboratory detection
Time frame: from 30 minutes before the surgery until to the time after stop infusion of remifentanil, , assessed up to about 2 hours
Plan to share: Yes — The individual participant data for this study is available from the sponsor on reasonable request through email.
No publications or documents are linked to this record.
Ran from Jan 2022 to primary completion in May 2022, 4 months.
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This study is completed, as verified in Dec 2022. You cannot join it, but the record below documents what was studied.
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The Second Affiliated Hospital of Chongqing Medical University →