An observational study in Vitiligo, Depressive Episode and Recurrent Depressive Disorder, sponsored by Momentum Data. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-02.
Sponsored by Momentum Data · Observational
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with vitiligo compared to controls and to evaluate whether the relative risks may vary by different ethnicity.
This study has two primary outcomes 1) Prevalence and incidence of mental health condtions in people diagnosed with vitiligo compared to matched controls and 2) Primary care and secondary healthcare utilisation in patients diagnosed with vitiligo and having a prevalent depressive conditon compared to matched controls. In addition, the study examines risk of time off work and unemployment in people diagnosed with vitiligo compared to matched controls.
343 studies on the registry are indexed under Vitiligo; 96 are open to participants now.
This study's enrollment of 36,104 is above the median of 114 across 67 observational studies indexed under Vitiligo.
Browse Vitiligo studies →Momentum Data is the lead sponsor of 11 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
This study will use routinely collected and collated data from OPCRD to provide a broadly representative sample of the population of the UK.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with a confirmed diagnosis of Vitiligo within the study period will be included as cases for analysis.
Other: Exposure of mental health condtion of interest
The controls will be defined by matching cases with people who have never been diagnosed with vitiligo either prior to or during the study period, by age and sex, at General Practice level.
Other: Exposure of mental health condtion of interest
Common mental health conditions consist of depressive episodes, recurrent depressive disorder and anxiety disorder.
Number of Participants With Depressive Episodes
Prevalence of common mental health conditions (depressive episodes) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Risk of Depressive Episodes Within Adult Patients With Vitiligo
Adjusted hazard ratio calculated using Cox proportional hazards models
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Number of Participants With Anxiety Disorder
Prevalence of common mental health conditions (Anxiety Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Number of Participants With Recurrent Depressive Disorder
Prevalence of common mental health conditions (Recurrent Depressive Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Risk of Anxiety Disorder Within Adult Patients With Vitiligo
Adjusted hazard ratio calclulated using Cox Proportional hazard models
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Risk of Recurrent Depressive Disorder Within Adult Patients With Vitilgo
Adjusted hazard ratio calculated using Cox proportional hazards models. Adjusted for age, gender, ethnicity, social deprivation quintile, body mass index, smoking status, alcohol use and comorbidities (hypertension, hyperlipidaemia, type 2 diabetes, atrial fibrillation, angina, myocardial infarction, heart failure, stroke, chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver disease and dementia).
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
| Milestone | Cases | Controls |
|---|---|---|
| Started | 7224 | 28880 |
| Completed | 7224 | 28880 |
| Not completed | 0 | 0 |
Prevalence of common mental health conditions (depressive episodes) in adult people diagnosed with vitiligo and matched controls without vitiligo.
| Participants | Cases | Controls |
|---|---|---|
| Number of Participants With Depressive Episodes | 1018 | 4007 |
Adjusted hazard ratio calculated using Cox proportional hazards models
| Participants | Cases | Controls (reference group) |
|---|---|---|
| Risk of Depressive Episodes Within Adult Patients With Vitiligo | 157 | 501 |
Prevalence of common mental health conditions (Anxiety Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
| Participants | Cases | Controls |
|---|---|---|
| Number of Participants With Anxiety Disorder | 569 | 2031 |
Prevalence of common mental health conditions (Recurrent Depressive Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
| Participants | Cases | Controls |
|---|---|---|
| Number of Participants With Recurrent Depressive Disorder | 1093 | 4305 |
Adjusted hazard ratio calclulated using Cox Proportional hazard models
| Participants | Cases | Controls (reference group) |
|---|---|---|
| Risk of Anxiety Disorder Within Adult Patients With Vitiligo | 122 | 382 |
Adjusted hazard ratio calculated using Cox proportional hazards models. Adjusted for age, gender, ethnicity, social deprivation quintile, body mass index, smoking status, alcohol use and comorbidities (hypertension, hyperlipidaemia, type 2 diabetes, atrial fibrillation, angina, myocardial infarction, heart failure, stroke, chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver disease and dementia).
| Participants | Cases | Controls (reference group) |
|---|---|---|
| Risk of Recurrent Depressive Disorder Within Adult Patients With Vitilgo | 113 | 312 |
Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Cases | — | — | — |
| Controls | — | — | — |
| Age, Continuous(years) | Cases | Controls | Total |
|---|---|---|---|
| Median | 44 (33 to 58) | 44 (32 to 58) | 44 (32 to 58) |
| Age, Customized(Participants) | Cases | Controls | Total |
|---|---|---|---|
| Age group, years — 18-29 | 1377 | 5534 | 6911 |
| Age group, years — 30-39 | 1526 | 6087 | 7613 |
| Age group, years — 40-49 | 1463 | 5822 | 7285 |
| Age group, years — 50-59 | 1251 | 5006 | 6257 |
| Age group, years — 60-69 | 918 | 3647 | 4565 |
| Age group, years — 70-76 | 534 | 2155 | 2689 |
| Age group, years — 80+ | 155 | 629 | 784 |
| Sex: Female, Male(Participants) | Cases | Controls | Total |
|---|---|---|---|
| Female | 3828 | 15304 | 19132 |
| Male | 3396 | 13576 | 16972 |
| Race/Ethnicity, Customized(Participants) | Cases | Controls | Total |
|---|---|---|---|
| White | 3504 | 14013 | 17517 |
| Asian or Asian British | 1060 | 3200 | 4260 |
| Black, African, Caribbean or Black British | 170 | 556 | 726 |
| Mixed | 66 | 238 | 304 |
| Other | 259 | 1155 | 1414 |
| Not stated | 199 | 949 | 1148 |
| Missing | 1966 | 8769 | 10735 |
| Body Mass Index, Categorical(Participants) | Cases | Controls | Total |
|---|---|---|---|
| <18.5 Underweight | 174 | 670 | 844 |
| 18.5-24.9 Healthy weight | 2129 | 7544 | 9673 |
| 25-29.9 Overweight | 2282 | 8511 | 10793 |
| 30-34.9 Class I obesity | 1080 | 4316 | 5396 |
| 35-39.9 Class II obesity | 367 | 1674 | 2041 |
| >40 Class III obesity | 211 | 1013 | 1224 |
| Not recorded | 981 | 5152 | 6133 |
| Smoking Status, Categorical(Participants) | Cases | Controls | Total |
|---|---|---|---|
| Non-smoker | 2357 | 8629 | 10986 |
| Current smoker | 1147 | 5881 | 7028 |
| Ex-smoker | 3521 | 12862 | 16383 |
| Passive smoker | 30 | 77 | 107 |
| Not recorded | 169 | 1431 | 1600 |
| Alcohol use, Categorical(Participants) | Cases | Controls | Total |
|---|---|---|---|
| Non-drinker | 2438 | 8984 | 11422 |
| Safe use | 2799 | 11101 | 13900 |
| Excess use | 970 | 3604 | 4574 |
| Alcoholism | 116 | 499 | 615 |
| Not recorded | 901 | 4692 | 5593 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Yes — OPCRD data can be accessed by bone fide researchers for specific research projects subject to approval by Anonymised Data Ethics \& Protocol Transparency (ADEPT) Committee. The data utilised for this study cannot be made available without such approval.
Supporting information: Study protocol
Time frame: The data will be available subject to approvals for two years after the study publication date
Access criteria: Data sharing is subject to ADEPT committee approval
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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