An interventional study of Health kiosk in Opioid-Related Disorders, Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV), sponsored by April M Young. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by April M Young · Not applicable, Interventional, and Prevention
This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior and improve linkage to care in rural Appalachia. The proposed project will take place in two counties in Appalachian Kentucky, an epicenter for the intertwined national crises of overdoses, hepatitis C, and injection-related infections.
This is a Type 1 hybrid effectiveness study involving a community-level, controlled quasi-experimental trial to assess the impact of a community-tailored health kiosk on HIV, HCV, and overdose risk in rural Appalachia, and a mixed methods evaluation of implementation outcomes. The trial will compare the standard health department program (staffed, brick-and-mortar) to an enhanced model involving a health kiosk + standard health department program. The kiosk, referred to as the KyOSK (Kentucky Outreach Service Kiosk) will be tailored through a community-engaged adaptation process. For evaluation of the KyOSK, the investigators will enroll 750 People Who Use Drugs (PWUD) in the intervention (n=425) and comparison (n=325) counties, collectively referred to as the kiosk trial cohort. The kiosk trial cohort will be recruited from three sources: existing cohorts of PWUD, local agencies, and peer-referral. Throughout the trial and following the implementation outcome framework (IOF) measurement model by Proctor et al., acceptability, appropriateness, fidelity, cost, penetration, and sustainability will be assessed using a combination of validated scales, qualitative interviews, checklists, invoices, and program data. Following the trial, the investigators will use data collected from the kiosk cohort and implementation outcome assessment (primarily cost and reach) in a dynamic, deterministic model of HCV transmission and overdose to examine the impact and cost-effectiveness of the KyOSK model.
1,411 studies on the registry are indexed under Opioid-Related Disorders; 290 are open to participants now.
This study's enrollment of 752 is above the median of 63 across 1,123 interventional studies indexed under Opioid-Related Disorders.
Browse Opioid-Related Disorders studies →April M Young is the lead sponsor of 2 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Individuals are eligible if they are:
Exclusion Criteria:
Individuals are not eligible if they meet any of the exclusion criteria:
The intervention involves enhancing the health department's existing staffed model of service delivery with a KyOSK. The intervention county's staffed program operates identically to the comparison county. Both counties' staffed programs and the kiosk will use an identically structured unique ID to provide objective data on service engagement. The KyOSK will resemble a vending machine but with a touchscreen, audiovisual interface. The KyOSK will include naloxone, wound care kits, and supplies for basic needs (e.g., hygiene items, food, water, emergency blankets); offer overdose education materials; and an innovative call-back feature for care navigation by recovery coaches. While the KyOSK is operating, the county will continue to operate its traditional program.
Behavioral: Health kiosk
A staffed program located in the local department of health (DOH) and staffed by DOH personnel currently operates in the comparison county. The program provides supplies (e.g., naloxone, wound care kits, snacks, drinks, resource guides). A peer support specialist from a nearby recovery facility is present for consultation with clients (by request of client) during operating hours. New clients to the program "register" by providing information for establishment of a client ID and answer a brief survey of demographic and behavioral questions used by all state programs. Program clients will also receive a resource guide covering the same categories as those covered in the call-back feature of the KyOSK.
The intervention involves enhancing its existing health department model with a Kentucky Outreach Service Kiosk (KyOSK).
Change in number of days carrying naloxone
Self-reported recent (past 30-day) frequency of carrying naloxone (continuous)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in frequency of use of substance use treatment, detoxification, and/or peer-support services
Self-reported recent (past 6-month) frequency of engaging in substance use treatment services (binary)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in number of injection-related abscesses
Self-reported recent (past 6 month) number of injection-site abscesses among those who inject drugs (continuous)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in frequency of condom-less anal and/or vaginal sex
Self-reported recent (past 30-day) frequency of anal or vaginal sex without a condom (continuous; number and proportion of all sex events)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in frequency of overdose
Self-reported number of times overdosed in the past 6 months (continuous).
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in use of naloxone during overdose events by participants who witnessed an overdose
Self-reported number of times participant used naloxone to reverse someone's overdose in the past 6 months (continuous)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in number of days on medications for opioid use disorder (MOUD) among participants who use opioids to get high
Self-reported recent (past 30-day) frequency of being on MOUD (continuous)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in frequency of helping others access naloxone
Self-reported recent (past 6 months) frequency of providing naloxone to others (binary)
Time frame: Measured at 18-month follow-up and thereafter
Change in frequency of hospitalization for an injection-related infection
Self-reported recent (past 6 month) hospitalization for an injection-site infection among those who inject drugs (binary)
Time frame: Measured at baseline and then every 6 months up to 5 years
Change in frequency of helping others access wound care
Self-reported recent (past 6 month) frequency of providing wound care supplies to other (binary)
Time frame: Measured at 18-month follow-up and thereafter
Change in recovery capital
Composite measure of recent (past 6 month) self-reported social capital (receipt and provision of support), physical capital (housing, transportation, food security, technology, and health care access), and human capital (quality of life, experience of shame) (continuous)
Time frame: Measured at baseline and then every 6 months up to 5 years
Plan to share: No
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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April M Young